NTP TECHNICAL REPORT https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2018/march/tr596peerdraft.pdf ON THE TOXICOLOGY AND CARCINOGENESI STUDIES IN B6C3F1/N MICE EXPOSED TO WHOLE-BODY RADIO FREQUENCY RADIATION AT A FREQUENCY (1,900 MHz) AND MODULATIONS (GSM AND CDMA) USED BY CELL PHONES PT 2

NTP TECHNICAL REPORT
https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2018/march/tr596peerdraft.pdf

ON THE TOXICOLOGY AND CARCINOGENESI STUDIES IN B6C3F1/N MICE EXPOSED TO WHOLE-BODY RADIO FREQUENCY RADIATION AT A FREQUENCY (1,900 MHz) AND MODULATIONS (GSM AND CDMA) USED BY CELL PHONES
GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 A-17 Peer Review Draft NOT FOR ATTRIBUTION TABLE A4 Summary of the Incidence of Nonneoplastic Lesions in Male Mice Exposed to GSM-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Integumentary System Mammary gland (2) (5) (2) (8) Skin (90) (89) (90) (90) Cyst, squamous 1 (1%) Hyperkeratosis 1 (1%) Infiltration cellular, mixed cell 1 (1%) Inflammation, chronic 1 (1%) Ulcer 2 (2%) 2 (2%) 2 (2%) 1 (1%) Epidermis, hyperplasia, focal 1 (1%) Hair follicle, atrophy 2 (2%) Subcutaneous tissue, inflammation, granulomatous 1 (1%) Musculoskeletal System Bone (90) (88) (90) (90) Callus 1 (1%) Increased bone 1 (1%) Skeletal muscle (90) (89) (90) (90) Degeneration 1 (1%) 1 (1%) Infiltration cellular, lymphocyte 3 (3%) 5 (6%) 5 (6%) Inflammation, acute 1 (1%) 1 (1%) Inflammation, chronic active 1 (1%) Necrosis 1 (1%) Nervous System Brain (90) (89) (90) (90) Hemorrhage 2 (2%) 2 (2%) Infiltration cellular, lymphocyte 1 (1%) Inflammation, acute 1 (1%) Mineral 79 (88%) 81 (91%) 80 (89%) 76 (84%) Squamous cyst 1 (1%) Artery, meninges, inflammation, chronic active 1 (1%) 1 (1%) Brain trigeminal ganglion (69) (79) (72) (79) Nerve trigeminal (67) (53) (66) (63) Peripheral nerve, sciatic (89) (89) (90) (89) Axon, degeneration 9 (10%) 9 (10%) 9 (10) 4 (4%) Spinal cord (90) (89) (90) (90) Cyst, squamous 1 (1%) Degeneration 1 (1%) Hemorrhage 1 (1%) Necrosis 1 (1%) 1 (1%) 1 (1%) Artery, meninges, inflammation, chronic active 1 (1%) 2 (2%) 1 (1%) A-18 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE A4 Summary of the Incidence of Nonneoplastic Lesions in Male Mice Exposed to GSM-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Respiratory System Lung (90) (89) (90) (90) Congestion 2 (2%) 2 (2%) 3 (3%) 3 (3%) Hemorrhage 3 (3%) 5 (6%) 4 (4%) 3 (3%) Infiltration cellular, histiocyte 6 (7%) 1 (1%) 1 (1%) 2 (2%) Infiltration cellular, lymphocyte 1 (1%) 1 (1%) Infiltration, chronic active 1 (1%) Alveolar epithelium, hyperplasia, focal 6 (7%) 8 (9%) 8 (9%) 7 (8%) Bronchiole, foreign body 1 (1%) Bronchiole, inflammation, suppurative 1 (1%) Mediastinum (0) (0) (2) (1) Nose (90) (89) (90) (89) Inflammation, acute 1 (1%) Respiratory epithelium, accumulation, hyaline droplet 1 (1%) Respiratory epithelium, hyperplasia 5 (6%) Vomeronasal organ, fibrosis 1 (1%) Trachea (90) (89) (89) (90) Special Senses System Eye (90) (89) (90) (90) Phthisis bulbi 1 (1%) 3 (3%) 1 (1%) Cornea, fibrosis 1 (1%) Cornea, inflammation, chronic active 1 (1%) Optic nerve, degeneration 1 (1%) Retina, atrophy 1 (1%) Retina, degeneration 1 (1%) Harderian gland (88) (89) (90) (90) Hemorrhage 1 (1%) Hyperplasia, focal 2 (2%) 1 (1%) 2 (2%) 1 (1%) Infiltration cellular, lymphocyte 36 (41%) 36 (40%) 32 (36%) 40 (44%) Urinary System Kidney (90) (89) (90) (89) Bacteria 1 (1%) Infarct 7 (8%) 4 (4%) 4 (4%) 8 (9%) Infiltration cellular, histiocyte 1 (1%) Infiltration cellular, mixed cell 1 (1%) Inflammation, suppurative 1 (1%) Inflammation, granulomatous 1 (1%) Inflammation, acute 1 (1%) Metaplasia, osseous 3 (3%) 6 (7%) 5 (6%) 1 (1%) Mineral 2 (2%) Nephropathy, chronic progressive 74 (82%) 66 (74%) 76 (84%) 74 (83%) Bilateral, bacteria 1 (1%) Bilateral, inflammation, acute 1 (1%) 1 (1%) Bilateral, renal tubule, bacteria 1 (1%) Bilateral, renal tubule, pigment 1 (1%) 1 (1%) Glomerulus, cyst 1 (1%) 1 (1%) Interstitium, infiltration cellular, lymphocyte 41 (46%) 50 (56%) 56 (62%) 44 (49%) Pelvis, dilation 1 (1%) 1 (1%) GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 A-19 Peer Review Draft NOT FOR ATTRIBUTION TABLE A4 Summary of the Incidence of Nonneoplastic Lesions in Male Mice Exposed to GSM-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Urinary System (continued) Kidney (continued) (90) (89) (90) (89) Renal tubule, accumulation, hyaline droplet 1 (1%) Renal tubule, bacteria 1 (1%) Renal tubule, cyst 8 (9%) 3 (3%) 4 (4%) 5 (6%) Renal tubule, dilation 1 (1%) Renal tubule, mineral 1 (1%) 4 (4%) Urothelium, inflammation, chronic active 1 (1%) Urinary bladder (87) (88) (90) (89) Hemorrhage 3 (3%) Infiltration cellular, lymphocyte 26 (30%) 20 (23%) 24 (27%) 21 (24%) Inflammation, acute 1 (1%) Inflammation, chronic active 1 (1%) Transitional epithelium, hyperplasia, diffuse 1 (1%) Transitional epithelium, hyperplasia, multifocal 2 (2%) A-20 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft B-1 Peer Review Draft NOT FOR ATTRIBUTION APPENDIX B SUMMARY OF LESIONS IN FEMALE MICE EXPOSED TO GSM-MODULATED CELL PHONE RFR FOR 2 YEARS TABLE B1 Summary of the Incidence of Neoplasms in Female Mice Exposed to GSM-Modulated Cell Phone RFR for 2 Years.............................................................B-2 TABLE B2 Statistical Analysis of Primary Neoplasms in Female Mice Exposed to GSM-Modulated Cell Phone RFR for 2 Years.............................................................B-8 TABLE B3 Historical Incidence of Malignant Lymphoma in Control Female B6C3F1/N Mice..................B-11 TABLE B4 Summary of the Incidence of Nonneoplastic Lesions in Female Mice Exposed to GSM-Modulated Cell Phone RFR for 2 Years...........................................................B-12 B-2 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE B1 Summary of the Incidence of Neoplasms in Female Mice Exposed to GSM-Modulated Cell Phone RFR for 2 Yearsa Sham Control 2.5 W/kg 5 W/kg 10 W/kg Disposition Summary Animals initially in study 105 105 105 105 14-Week interim evaluation 15 15 15 15 Early deaths Moribund 9 9 9 6 Natural deaths 14 7 11 11 Survivors Died last week of study 1 4 2 1 Terminal euthanasia 66 70 68 72 Animals examined microscopically 100 100 100 100 Systems Examined at 14 Weeks with No Neoplasms Observed Alimentary System Cardiovascular System Endocrine System General Body System Genital System Hematopoietic System Integumentary System Musculoskeletal System Nervous System Respiratory System Special Senses System Urinary System 2-Year Study Alimentary System Esophagus (87) (90) (87) (90) Gallbladder (79) (75) (74) (72) Intestine large, cecum (84) (82) (83) (82) Fibrosarcoma, metastatic, skin 1 (1%) Leiomyosarcoma 1 (1%) Intestine large, colon (84) (84) (86) (85) Intestine large, rectum (88) (86) (88) (86) Fibrosarcoma, metastatic, skin 1 (1%) Osteosarcoma, metastatic, skin 1 (1%) Intestine small, duodenum (82) (83) (84) (81) Fibrosarcoma, metastatic, skin 1 (1%) Intestine small, ileum (83) (82) (82) (80) Intestine small, jejunum (84) (81) (81) (80) Adenoma 1 (1%) Liver (89) (90) (90) (89) Fibrosarcoma, metastatic, skin 1 (1%) Hemangiosarcoma 1 (1%) 1 (1%) Hepatoblastoma 1 (1%) Hepatocellular adenoma 14 (16%) 16 (18%) 11 (12%) 8 (9%) Hepatocellular adenoma, multiple 5 (6%) 2 (2%) 2 (2%) 2 (2%) Hepatocellular carcinoma 6 (7%) 6 (7%) 5 (6%) 5 (6%) Hepatocellular carcinoma, multiple 2 (2%) 1 (1%) 1 (1%) Hepatocholangiocarcinoma 1 (1%) Osteosarcoma, metastatic, bone 1 (1%) Osteosarcoma, metastatic, skin 1 (1%) GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 B-3 Peer Review Draft NOT FOR ATTRIBUTION TABLE B1 Summary of the Incidence of Neoplasms in Female Mice Exposed to GSM-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Alimentary System (continued) Mesentery (29) (24) (32) (30) Fibrosarcoma, metastatic, skin 1 (3%) Renal mesenchymal tumor, metastatic, kidney 1 (3%) Fat, hemangioma 1 (3%) Fat, lipoma 1 (4%) 1 (3%) Oral mucosa (0) (0) (2) (0) Pancreas (87) (88) (89) (86) Fibrosarcoma, metastatic, skin 1 (1%) Hemangioma 1 (1%) Hepatocellular carcinoma, metastatic, liver 1 (1%) Renal mesenchymal tumor, metastatic, kidney 1 (1%) Acinus, carcinoma 1 (1%) Salivary glands (89) (89) (90) (90) Adenocarcinoma, metastatic, Harderian gland 1 (1%) Stomach, forestomach (86) (89) (90) (85) Fibrosarcoma, metastatic, skin 1 (1%) Squamous cell papilloma 1 (1%) Stomach, glandular (85) (87) (85) (85) Fibrosarcoma, metastatic, skin 1 (1%) Tongue (0) (0) (1) (0) Tooth (0) (0) (1) (0) Cardiovascular System Aorta (84) (88) (90) (89) Blood vessel (0) (0) (2) (0) Heart (90) (90) (90) (90) Adenocarcinoma, metastatic, Harderian gland 1 (1%) Hemangioma 1 (1%) Osteosarcoma, metastatic, skin 1 (1%) Endocrine System Adrenal cortex (84) (88) (90) (90) Adenoma 1 (1%) Adrenal medulla (83) (84) (86) (87) Pheochromocytoma benign 1 (1%) Pheochromocytoma malignant 2 (2%) Islets, pancreatic (87) (88) (90) (86) Adenoma 1 (1%) 1 (1%) Carcinoma 1 (1%) 1 (1%) Parathyroid gland (60) (57) (64) (62) Pituitary gland (80) (80) (84) (84) Pars distalis, adenoma 6 (8%) 5 (6%) 7 (8%) 5 (6%) Pars distalis, carcinoma 2 (2%) 1 (1%) Thyroid gland (86) (89) (86) (86) C-cell, carcinoma 1 (1%) Follicular cell, carcinoma 1 (1%) B-4 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE B1 Summary of the Incidence of Neoplasms in Female Mice Exposed to GSM-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) General Body System Peritoneum (0) (0) (1) (0) Tissue NOS (1) (1) (1) (2) Hemangiosarcoma 1 (50%) Abdominal, osteosarcoma, metastatic, skin 1 (100%) Genital System Clitoral gland (82) (84) (80) (86) Ovary (75) (86) (82) (80) Cystadenoma 2 (3%) 2 (2%) 3 (4%) 6 (8%) Granulosa cell tumor benign 1 (1%) 1 (1%) 1 (1%) Hemangioma 2 (3%) 2 (2%) Hemangiosarcoma 1 (1%) Luteoma 1 (1%) Teratoma benign 2 (2%) 1 (1%) Thecoma malignant 1 (1%) Oviduct (0) (0) (1) (0) Uterus (89) (90) (90) (89) Adenocarcinoma 1 (1%) Fibroma 1 (1%) Fibrosarcoma, metastatic, skin 1 (1%) Hemangiosarcoma 1 (1%) Leiomyoma 1 (1%) Polyp stromal 3 (3%) 2 (2%) 2 (2%) Vagina (0) (0) (1) (0) Hematopoietic System Bone marrow (90) (89) (89) (90) Hemangiosarcoma 2 (2%) 1 (1%) Lymph node (18) (20) (16) (14) Bronchial, alveolar/bronchiolar carcinoma, metastatic, lung 1 (6%) Bronchial, fibrosarcoma, metastatic, skin 1 (6%) Lymph node, mandibular (76) (77) (81) (83) Lymph node, mesenteric (71) (84) (80) (83) Fibrosarcoma, metastatic, skin 1 (1%) Hemangiosarcoma 1 (1%) Renal mesenchymal tumor, metastatic, kidney 1 (1%) Spleen (86) (87) (89) (87) Hemangiosarcoma 2 (2%) 2 (2%) Thymus (85) (80) (84) (86) GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 B-5 Peer Review Draft NOT FOR ATTRIBUTION TABLE B1 Summary of the Incidence of Neoplasms in Female Mice Exposed to GSM-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Integumentary System Mammary gland (85) (88) (88) (84) Adenocarcinoma 1 (1%) 1 (1%) Skin (90) (90) (90) (90) Sebaceous gland, adenoma 1 (1%) Subcutaneous tissue, fibroma 1 (1%) Subcutaneous tissue, fibrosarcoma 3 (3%) 3 (3%) Subcutaneous tissue, hemangiosarcoma 2 (2%) Subcutaneous tissue, lipoma 1 (1%) Subcutaneous tissue, malignant fibrous histiocytoma 1 (1%) 3 (3%) Subcutaneous tissue, osteosarcoma 1 (1%) Subcutaneous tissue, sarcoma 2 (2%) 1 (1%) 1 (1%) Musculoskeletal System Bone (90) (90) (89) (90) Hemangioma 1 (1%) Hemangiosarcoma 1 (1%) Osteosarcoma 1 (1%) Skeletal muscle (89) (90) (90) (90) Adenocarcinoma, metastatic, Harderian gland 1 (1%) Osteosarcoma 1 (1%) 1 (1%) Rhabdomyosarcoma 1 (1%) Sarcoma, metastatic, skin 1 (1%) Nervous System Brain (87) (90) (90) (90) Carcinoma, metastatic, pituitary gland 2 (2%) 1 (1%) Meningioma benign 1 (1%) Osteosarcoma, metastatic, skeletal muscle 1 (1%) Brain trigeminal ganglion (75) (74) (80) (79) Nerve trigeminal (56) (58) (53) (35) Carcinoma, metastatic, pituitary gland 1 (3%) Peripheral nerve (0) (0) (1) (0) Peripheral nerve, sciatic (88) (87) (88) (88) Spinal cord (90) (90) (90) (90) B-6 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE B1 Summary of the Incidence of Neoplasms in Female Mice Exposed to GSM-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Respiratory System Larynx (0) (0) (2) (0) Lung (90) (90) (90) (90) Adenocarcinoma, metastatic, Harderian gland 1 (1%) Alveolar/bronchiolar adenoma 3 (3%) 5 (6%) 7 (8%) 1 (1%) Alveolar/bronchiolar adenoma, multiple 1 (1%) Alveolar/bronchiolar carcinoma 3 (3%) 1 (1%) 1 (1%) Carcinoma, metastatic, pancreas 1 (1%) Carcinoma, metastatic, thyroid gland 1 (1%) Fibrosarcoma, metastatic, skin 1 (1%) 2 (2%) Hepatocellular carcinoma, metastatic, liver 2 (2%) 2 (2%) 1 (1%) Hepatocholangiocarcinoma, metastatic, liver 1 (1%) Osteosarcoma, metastatic, bone 1 (1%) Osteosarcoma, metastatic, skeletal muscle 1 (1%) Osteosarcoma, metastatic, skin 1 (1%) Sarcoma, metastatic, skin 1 (1%) Mediastinum (2) (0) (0) (0) Hepatocellular carcinoma, metastatic, liver 1 (50%) Nose (89) (90) (90) (90) Adenocarcinoma, metastatic, Harderian gland 1 (1%) Pleura (0) (0) (1) (0) Trachea (90) (89) (90) (90) Special Senses System Ear (0) (0) (1) (0) Eye (89) (88) (90) (90) Harderian gland (89) (90) (90) (87) Adenocarcinoma 1 (1%) 1 (1%) Adenoma 4 (4%) 7 (8%) 5 (6%) 6 (7%) Lacrimal gland (0) (1) (2) (0) Zymbal’s gland (0) (0) (1) (0) Urinary System Kidney (89) (87) (89) (88) Renal mesenchymal tumor 1 (1%) Renal tubule, adenoma 2 (2%) Ureter (0) (0) (1) (0) Urethra (0) (0) (1) (0) Urinary bladder (86) (87) (86) (86) Systemic Lesions Multiple organsb (90) (90) (90) (90) Histiocytic sarcoma 8 (9%) 2 (2%) 8 (9%) 5 (6%) Leukemia erythrocytic 1 (1%) Lymphoma malignant 2 (2%) 13 (14%) 9 (10%) 6 (7%) GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 B-7 Peer Review Draft NOT FOR ATTRIBUTION TABLE B1 Summary of the Incidence of Neoplasms in Female Mice Exposed to GSM-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Neoplasm Summary Total animals with primary neoplasmsc 2-Year study 59 55 57 44 Total primary neoplasms 2-Year study 85 79 85 64 Total animals with benign neoplasms 2-Year study 36 37 35 29 Total benign neoplasms 2-Year study 47 48 43 35 Total animals with malignant neoplasms 2-Year study 33 27 35 24 Total malignant neoplasms 2-Year study 38 31 42 29 Total animals with metastatic neoplasms 2-Year study 9 1 9 2 Total metastatic neoplasms 2-Year study 29 5 11 3 a Number of animals examined microscopically at the site and the number of animals with neoplasm b Number of animals with any tissue examined microscopically c Primary neoplasms: all neoplasms except metastatic neoplasms B-8 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE B2 Statistical Analysis of Primary Neoplasms in Female Mice Exposed to GSM-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg Harderian Gland: Adenoma Overall ratea 4/90 (4%) 7/90 (8%) 5/90 (6%) 6/90 (7%) Adjusted rateb 5.0% 8.3% 6.0% 7.2% Terminal ratec 4/67 (6%) 4/72 (6%) 5/69 (7%) 6/72 (8%) First incidence (days) 739 (T) 562 739 (T) 739 (T) Poly-3 testd P=0.436 P=0.299 P=0.524 P=0.398 Harderian Gland: Adenoma or Carcinoma Overall rate 4/90 (4%) 8/90 (9%) 6/90 (7%) 6/90 (7%) Adjusted rate 5.0% 9.4% 7.2% 7.2% Terminal rate 4/67 (6%) 4/72 (6%) 6/69 (9%) 6/72 (8%) First incidence (days) 739 (T) 562 739 (T) 739 (T) Poly-3 test P=0.471 P=0.214 P=0.397 P=0.398 Liver: Hepatocellular Adenoma Overall rate 19/89 (21%)e 18/90 (20%) 13/90 (14%) 10/89 (11%) Adjusted rate 23.6% 21.5% 15.6% 12.0% Terminal rate 17/67 (25%) 17/72 (24%) 11/69 (16%) 9/72 (13%) First incidence (days) 511 638 674 700 Poly-3 test P=0.022N P=0.448N P=0.134N P=0.041N Liver: Hepatocellular Carcinoma Overall rate 8/89 (9%) 6/90 (7%) 6/90 (7%) 6/89 (7%) Adjusted rate 10.0% 7.2% 7.2% 7.2% Terminal rate 7/67 (10%) 4/72 (6%) 5/69 (7%) 4/72 (6%) First incidence (days) 656 650 701 720 Poly-3 test P=0.348N P=0.354N P=0.358N P=0.361N Liver: Hepatocellular Adenoma or Carcinoma Overall rate 25/89 (28%) 24/90 (27%) 17/90 (19%) 15/89 (17%) Adjusted rate 30.9% 28.5% 20.3% 18.0% Terminal rate 22/67 (33%) 21.72 (29%) 14/69 (20%) 12/72 (17%) First incidence (days) 511 638 674 700 Poly-3 test P=0.020N P=0.436N P=0.082N P=0.040N Liver: Hepatocellular Carcinoma or Hepatoblastoma Overall rate 9/89 (10%) 6/90 (7%) 6/90 (7%) 6/89 (7%) Adjusted rate 11.3% 7.2% 7.2% 7.2% Terminal rate 8/67 (12%) 4/72 (6%) 5/69 (7%) 4/72 (6%) First incidence (days) 656 650 701 720 Poly-3 test P=0.268N P=0.261N P=0.265N P=0.267N Lung: Alveolar/bronchiolar Adenoma Overall rate 3/90 (3%) 6/90 (7%) 7/90 (8%) 1/90 (1%) Adjusted rate 3.8% 7.2% 8.4% 1.2% Terminal rate 3/67 (5%) 6/72 (8%) 7/69 (10%) 1/72 (1%) First incidence (days) 739 (T) 739 (T) 739 (T) 739 (T) Poly-3 test P=0.190N P=0.268 P=0.180 P=0.292N Lung: Alveolar/bronchiolar Adenoma or Carcinoma Overall rate 6/90 (7%) 6/90 (7%) 7/90 (8%) 2/90 (2%) Adjusted rate 7.5% 7.2% 8.4% 2.4% Terminal rate 5/67 (8%) 6/72 (8%) 7/69 (10%) 2/72 (3%) First incidence (days) 607 739 (T) 739 (T) 739 (T) Poly-3 test P=0.108N P=0.592N P=0.526 P=0.127N GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 B-9 Peer Review Draft NOT FOR ATTRIBUTION TABLE B2 Statistical Analysis of Primary Neoplasms in Female Mice Exposed to GSM-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg Ovary: Cystadenoma Overall rate 2/75 (3%) 2/86 (2%) 3/82 (4%) 6/80 (8%) Adjusted rate 3.0% 2.5% 3.9% 7.9% Terminal rate 2/56 (4%) 2/69 (3%) 3/65 (5%) 6/67 (9%) First incidence (days) 739 (T) 739 (T) 739 (T) 739 (T) Poly-3 test P=0.067 P=0.623N P=0.564 P=0.186 Pituitary Gland (Pars Distalis): Adenoma Overall rate 6/80 (8%) 5/80 (6%) 7/84 (8%) 5/84 (6%) Adjusted rate 8.4% 6.8% 9.0% 6.4% Terminal rate 5/60 (8%) 5/65 (8%) 4/64 (6%) 5/68 (7%) First incidence (days) 703 739 (T) 712 739 (T) Poly-3 test P=0.417N P=0.475N P=0.563 P=0.435N Pituitary Gland (Pars Distalis): Adenoma or Carcinoma Overall rate 6/80 (8%) 5/80 (6%) 9/84 (11%) 6/84 (7%) Adjusted rate 8.4% 6.8% 11.5% 7.6% Terminal rate 5/60 (8%) 5/65 (8%) 4/64 (6%) 5/68 (7%) First incidence (days) 703 739 (T) 606 676 Poly-3 test P=0.553 P=0.475N P=0.362 P=0.549N Skin (Subcutaneous Tissue): Fibrosarcoma or Sarcoma Overall rate 5/90 (6%) 0/90 (0%) 4/90 (4%) 1/90 (1%) Adjusted rate 6.2% 0.0% 4.8% 1.2% Terminal rate 1/67 (2%) 0/72 (0%) 1/69 (1%) 0/72 (0%) First incidence (days) 607 —f 646 607 Poly-3 test P=0.159N P=0.031N P=0.478N P=0.098N Skin (Subcutaneous Tissue): Fibroma, Fibrosarcoma, or Sarcoma Overall rate 6/90 (7%) 0/90 (0%) 4/90 (4%) 1/90 (1%) Adjusted rate 7.4% 0.0% 4.8% 1.2% Terminal rate 2/67 (3%) 0/72 (0%) 1/69 (1%) 0/72 (0%) First incidence (days) 607 — 646 607 Poly-3 test P=0.094N P=0.016N P=0.351N P=0.055N Skin (Subcutaneous Tissue): Fibrosarcoma, Sarcoma, or Malignant Fibrous Histiocytoma Overall rate 5/90 (6%) 1/90 (1%) 7/90 (8%) 1/90 (1%) Adjusted rate 6.2% 1.2% 8.4% 1.2% Terminal rate 1/67 (2%) 0/72 (0%) 3/69 (4%) 0/72 (0%) First incidence (days) 607 562 646 607 Poly-3 test P=0.193N P=0.097N P=0.407 P=0.098N Skin (Subcutaneous Tissue): Fibroma, Fibrosarcoma, Sarcoma, or Malignant Fibrous Histiocytoma Overall rate 6/90 (7%) 1/90 (1%) 7/90 (8%) 1/90 (1%) Adjusted rate 7.4% 1.2% 8.4% 1.2% Terminal rate 2/67 (3%) 0/72 (0%) 3/69 (4%) 0/72 (0%) First incidence (days) 607 562 646 607 Poly-3 test P=0.125N P=0.054N P=0.527 P=0.055N All Organs: Hemangiosarcoma Overall rate 2/90 (2%) 5/90 (6%) 3/90 (3%) 3/90 (3%) Adjusted rate 2.5% 6.0% 3.6% 3.6% Terminal rate 1/67 (2%) 4/72 (6%) 1/69 (1%) 2/72 (3%) First incidence (days) 703 638 629 720 Poly-3 test P=0.572N P=0.238 P=0.521 P=0.518 B-10 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE B2 Statistical Analysis of Primary Neoplasms in Female Mice Exposed to GSM-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg All Organs: Hemangioma or Hemangiosarcoma Overall rate 6/90 (7%) 7/90 (8%) 4/90 (4%) 4/90 (4%) Adjusted rate 7.5% 8.4% 4.8% 4.8% Terminal rate 5/97 (8%) 6/72 (8%) 1/69 (1%) 3/72 (4%) First incidence (days) 703 638 629 720 Poly-3 test P=0.218N P=0.533 P=0.343N P=0.348N All Organs: Histiocytic Sarcoma Overall rate 8/90 (9%) 2/90 (2%) 8/90 (9%) 5/90 (6%) Adjusted rate 9.7% 2.4% 9.5% 5.9% Terminal rate 2/67 (3%) 1/72 (1%) 3/69 (4%) 1/72 (1%) First incidence (days) 562 458 629 660 Poly-3 test P=0.419N P=0.048N P=0.587N P=0.270N All Organs: Malignant Lymphoma Overall rate 2/90 (2%) 13/90 (14%) 9/90 (10%) 6/90 (7%) Adjusted rate 2.5% 15.6% 10.7% 7.1% Terminal rate 1/67 (1%) 12/72 (17%) 5/69 (7%) 3/72 (4%) First incidence (days) 604 731 516 590 Poly-3 test P=0.474 P=0.004 P=0.035 P=0.153 (T) Terminal euthanasia a Number of neoplasm-bearing animals/number of animals examined. Denominator is number of animals examined microscopically for liver, lung, ovary, and pituitary gland; for other tissues, denominator is number of animals necropsied. b Poly-3 estimated neoplasm incidence after adjustment for intercurrent mortality c Observed incidence at terminal euthanasia d Beneath the sham control incidence is the P value associated with the trend test. Beneath the exposed group incidence are the P values corresponding to pairwise comparisons between the sham controls and that exposed group. The Poly-3 test accounts for differential mortality in animals that do not reach terminal euthanasia. A negative trend or a lower incidence in an exposure group is indicated by N. e A single incidence of hepatoblastoma occurred in an animal that also had an adenoma. f Not applicable; no neoplasms in animal group GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 B-11 Peer Review Draft NOT FOR ATTRIBUTION TABLE B3 Historical Incidence of Malignant Lymphoma in Control Female B6C3F1/N Micea Incidence in Controls Overall Historical Incidence: All Routes Total (%) 89/590 (15.1%) Mean ± standard deviation 16.0% ± 8.3% Range 2%-36% a Data as of August 2017; includes data for histiocytic, lymphocytic, mixed, unspecified, or undifferentiated cell types B-12 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE B4 Summary of the Incidence of Nonneoplastic Lesions in Female Mice Exposed to GSM-Modulated Cell Phone RFR for 2 Yearsa Sham Control 2.5 W/kg 5 W/kg 10 W/kg Disposition Summary Animals initially in study 105 105 105 105 14-Week interim evaluation 15 15 15 15 Early deaths Moribund 9 9 9 6 Natural deaths 14 7 11 11 Survivors Died last week of study 1 4 2 1 Terminal euthanasia 66 70 68 72 Animals examined microscopically 100 100 100 100 14-Week Interim Evaluation Alimentary System Liver (10) (10) (10) (9) Inflammation, focal 1 (10%) 2 (20%) 4 (40%) 3 (33%) Necrosis 1 (10%) Salivary glands (10) (10) (10) (9) Infiltration cellular, lymphocyte 3 (30%) Stomach, glandular (10) (10) (10) (9) Infiltration cellular, mixed cell 1 (10)% Endocrine System Thyroid gland (10) (10) (10) (9) Infiltration cellular, lymphocyte 1 (10%) Hematopoietic System Thymus (10) (10) (10) (9) Hemorrhage 2 (20%) 3 (30%) Integumentary System Skin (10) (10) (10) (9) Hair follicle, inflammation, chronic active 1 (11%) Nervous System Spinal cord (10) (10) (10) (10) Cyst, squamous, multiple 1 (10%) Respiratory System Lung (10) (10) (10) (9) Hemorrhage 1 (10%) Special Senses System Harderian gland (10) (10) (10) (9) Infiltration cellular, lymphocyte 1 (11%) a Number of animals examined microscopically at the site and the number of animals with lesion GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 B-13 Peer Review Draft NOT FOR ATTRIBUTION TABLE B4 Summary of the Incidence of Nonneoplastic Lesions in Female Mice Exposed to GSM-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 14-Week Interim Evaluation (continued) Urinary System Kidney (10) (10) (10) (10) Nephropathy, chronic progressive 1 (10%) Interstitium, infiltration cellular, lymphocyte 3 (30%) Urinary bladder (10) (10) (10) (9) Infiltration cellular, lymphocyte 1 (11%) Systems Examined with No Lesions Observed Cardiovascular System General Body System Genital System Musculoskeletal System 2-Year Study Alimentary System Esophagus (87) (90) (87) (90) Gallbladder (79) (75) (74) (72) Cyst 1 (1%) 1 (1%) Infiltration cellular, lymphocyte 2 (3%) 5 (7%) 2 (3%) 4 (6%) Intestine large, cecum (84) (82) (83) (82) Intestine large, colon (84) (84) (86) (85) Intestine large, rectum (88) (86) (88) (86) Intestine small, duodenum (82) (83) (84) (81) Inflammation, acute 1 (1%) Intestine small, ileum (83) (82) (82) (80) Peyer’s patch, hyperplasia, lymphoid 1 (1%) Intestine small, jejunum (84) (81) (81) (80) Peyer’s patch, hyperplasia, lymphoid 1 (1%) 1 (1%) Liver (89) (90) (90) (89) Basophilic focus 4 (4%) 2 (2%) 5 (6%) 5 (6%) Clear cell focus 1 (1%) Eosinophilic focus 2 (2%) 1 (1%) 1 (1%) Extramedullary hematopoiesis 1 (1%) 1 (1%) Fatty change 7 (8%) 1 (1%) 2 (2%) Hemorrhage 1 (1%) 1 (1%) 1 (1%) Infiltration cellular, lymphocyte 33 (37%) 25 (28%) 21 (23%) 32 (36%) Infiltration cellular, mononuclear cell 1 (1%) 2 (2%) 1 (1%) Infiltration cellular, polymorphonuclear 1 (1%) Inflammation, focal 4 (4%) 2 (2%) Inflammation, acute 1 (1%) Inflammation, chronic active 1 (1%) Mixed cell focus 5 (6%) 1 (1%) 1 (1%) Necrosis 6 (7%) 5 (6%) 6 (7%) 3 (3%) Artery, inflammation, chronic 1 (1%) Bile duct, cyst 1 (1%) 1 (1%) Centrilobular, hepatocyte, hypertrophy 1 (1%) Hepatocyte, fatty change, focal 3 (3%) 1 (1%) Hepatocyte, hyperplasia 1 (1%) Hepatocyte, hypertrophy 1 (1%) Hepatocyte, inclusion body intracytoplasmic 1 (1%) Hepatocyte, vacuolization cytoplasmic 4 (4%) 1 (1%) Kupffer cell, hyperplasia 1 (1%) B-14 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE B4 Summary of the Incidence of Nonneoplastic Lesions in Female Mice Exposed to GSM-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Alimentary System (continued) Mesentery (29) (24) (32) (30) Artery, inflammation, chronic 2 (8%) Fat, infiltration cellular, lymphocyte 2 (7%) 1 (4%) Fat, inflammation, granulomatous 1 (4%) Fat, inflammation, chronic active 1 (3%) Fat, mineral 1 (4%) 1 (3%) Fat, necrosis 25 (86%) 19 (79%) 27 (84%) 27 (90%) Oral mucosa (0) (0) (2) (0) Pancreas (87) (88) (89) (86) Degeneration 1 (1%) Infiltration cellular, lipocyte 1 (1%) 1 (1%) Infiltration cellular, histiocyte 1 (1%) Infiltration cellular, lymphocyte 27 (31%) 26 (30%) 30 (34%) 24 (28%) Inflammation, suppurative 1 (1%) Inflammation, chronic active 1 (1%) Necrosis 1 (1%) Acinus, atrophy 2 (2%) 1 (1%) Duct, cyst 1 (1%) 1 (1%) 2 (2%) 3 (3%) Duct, inflammation, chronic active 1 (1%) Salivary glands (89) (89) (90) (90) Atrophy 1 (1%) Infiltration cellular, lymphocyte 59 (66%) 54 (61%) 55 (61%) 62 (69%) Inflammation, acute 1 (1%) Mineral 1 (1%) Arteriole, inflammation, chronic 1 (1%) Stomach, forestomach (86) (89) (90) (85) Cyst 1 (1%) Hyperkeratosis 1 (1%) Ulcer 1 (1%) Epithelium, hyperplasia, focal 2 (2%) Stomach, glandular (85) (87) (85) (85) Cyst 3 (4%) 3 (3%) 4 (5%) Infiltration cellular, lymphocyte 1 (1%) 2 (2%) Ulcer 1 (1%) Tongue (0) (0) (1) (0) Tooth (0) (0) (1) (0) Cardiovascular System Aorta (84) (88) (90) (89) Degeneration 1 (1%) Inflammation, chronic active 1 (1%) Blood vessel (0) (0) (2) (0) Heart (90) (90) (90) (90) Bacteria 1 (1%) 1 (1%) 2 (2%) Cardiomyopathy 3 (3%) 1 (1%) 3 (3%) 3 (3%) Thrombus 3 (3%) 1 (1%) 2 (2%) Artery, inflammation, chronic active 4 (4%) 1 (1%) Endocardium, hyperplasia 1 (1%) Epicardium, infiltration cellular, mixed cell 1 (1%) Epicardium, infiltration cellular, mononuclear cell 1 (1%) GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 B-15 Peer Review Draft NOT FOR ATTRIBUTION TABLE B4 Summary of the Incidence of Nonneoplastic Lesions in Female Mice Exposed to GSM-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Cardiovascular System (continued) Heart (continued) (90) (90) (90) (90) Myocardium, fibrosis 1 (1%) Myocardium, infiltration cellular, lymphocyte 1 (1%) 2 (2%) Myocardium, inflammation, acute 1 (1%) 2 (2%) Myocardium, inflammation, chronic active 1 (1%) Myocardium, mineral 4 (4%) 1 (1%) Valve, hemorrhage 1 (1%) Valve, infiltration cellular, lymphocyte 1 (1%) Valve, inflammation, chronic 1 (1%) Valve, thrombus 1 (1%) Endocrine System Adrenal cortex (84) (88) (90) (90) Accessory adrenal cortical nodule 1 (1%) 1 (1%) 1 (1%) Angiectasis 1 (1%) Hemorrhage 1 (1%) 3 (3%) Mineral 1 (1%) Vacuolization cytoplasmic 2 (2%) Bilateral, extramedullary hematopoiesis 1 (1%) Bilateral, hyperplasia, focal 1 (1%) Bilateral, vacuolization cytoplasmic 3 (3%) 1 (1%) 1 (1%) Subcapsular, hyperplasia 81 (96%) 85 (97%) 88 (98%) 86 (96%) Adrenal medulla (83) (84) (86) (87) Hemorrhage 2 (2%) 1 (1%) Hyperplasia 2 (2%) Mineral 1 (1%) Islets, pancreatic (87) (88) (90) (86) Hyperplasia 1 (1%) 3 (3%) 1 (1%) Infiltration cellular, lymphocyte 3 (3%) 2 (2%) 2 (2%) 3 (3%) Parathyroid gland (60) (57) (64) (62) Cyst 1 (2%) Infiltration cellular, lymphocyte 1 (2%) 1 (2%) Pituitary gland (80) (80) (84) (84) Pars distalis, angiectasis 2 (3%) 7 (9%) 6 (7%) 5 (6%) Pars distalis, cyst 1 (1%) 3 (4%) 1 (1%) Pars distalis, cytoplasmic alteration 1 (1%) Pars distalis, hyperplasia, focal 2 (3%) 4 (5%) 5 (6%) 4 (5%) Thyroid gland (86) (89) (86) (86) Infiltration cellular, lymphocyte 1 (1%) 6 (7%) 6 (7%) 3 (3%) Ultimobranchial cyst 2 (2%) Follicle, cyst 1 (1%) 1 (1%) Follicular cell, hyperplasia, focal 4 (4%) General Body System Peritoneum (0) (0) (1) (0) Tissue NOS (1) (1) (1) (2) B-16 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE B4 Summary of the Incidence of Nonneoplastic Lesions in Female Mice Exposed to GSM-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Genital System Clitoral gland (82) (84) (80) (86) Infiltration cellular, lymphocyte 3 (4%) 1 (1%) Duct, cyst 1 (1%) 1 (1%) Ovary (75) (86) (82) (80) Angiectasis 1 (1%) 1 (1%) 2 (3%) Cyst 9 (12%) 13 (15%) 8 (10%) 7 (9%) Cyst, squamous 1 (1%) Hemorrhage 1 (1%) 2 (2%) 1 (1%) Hyperplasia, cystic, papillary 1 (1%) 1 (1%) Hyperplasia, tubulostromal 1 (1%) Infiltration cellular, lymphocyte 1 (1%) Mineral 1 (1%) Thrombus 1 (1%) 1 (1%) Bursa, cyst 1 (1%) Follicle, cyst 9 (12%) 11 (13%) 6 (7%) 7 (9%) Granulosa cell, hyperplasia 2 (2%) Paraovarian tissue, cyst 1 (1%) Oviduct (0) (0) (1) (0) Uterus (89) (90) (90) (89) Angiectasis 1 (1%) 6 (7%) 5 (6%) 3 (3%) Congestion 1 (1%) Dilation 35 (39%) 29 (32%) 30 (33%) 26 (29%) Hemorrhage 1 (1%) 1 (1%) 1 (1%) Infiltration cellular, lymphocyte 1 (1%) Inflammation, acute 1 (1%) Thrombus 1 (1%) Endometrium, cyst 3 (3%) 1 (1%) Endometrium, hyperplasia 1 (1%) 1 (1%) Endometrium, hyperplasia, cystic 68 (76%) 75 (83%) 72 (80%) 68 (76%) Endometrium, metaplasia, squamous 1 (1%) Vagina (0) (0) (1) (0) Hematopoietic System Bone marrow (90) (89) (89) (90) Hypercellularity 7 (8%) 8 (9%) 4 (4%) 4 (4%) Hypocellularity 1 (1%) 1 (1%) Myeloid cell, hypercellularity 1 (1%) Lymph node (18) (20) (16) (14) Hemorrhage 1 (6%) 1 (7%) Hyperplasia, lymphoid 1 (6%) Axillary, infiltration cellular, mixed cell 1 (6%) Axillary, pigment 1 (6%) Bronchial, hyperplasia, lymphoid 2 (11%) 4 (29%) Iliac, erythrophagocytosis 1 (5%) Iliac, hemorrhage 1 (6%) 2 (13%) Iliac, hyperplasia, lymphoid 4 (22%) 2 (10%) 6 (38%) 2 (14%) Iliac, infiltration cellular, histiocyte 1 (5%) 1 (6%) Iliac, infiltration cellular, mixed cell 1 (6%) 1 (5%) 4 (25%) Iliac, pigment 4 (25%) Lumbar, hyperplasia, lymphoid 1 (5%) Lumbar, infiltration cellular, mixed cell 1 (6%) Mediastinal, hyperplasia, lymphoid 1 (6%) 2 (10%) Mediastinal, infiltration cellular, plasma cell 1 (5%) GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 B-17 Peer Review Draft NOT FOR ATTRIBUTION TABLE B4 Summary of the Incidence of Nonneoplastic Lesions in Female Mice Exposed to GSM-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Hematopoietic System (continued) Lymph node (continued) (18) (20) (16) (14) Pancreatic, hyperplasia, lymphoid 1 (6%) Renal, erythrophagocytosis 1 (6%) Renal, hemorrhage 1 (6%) Renal, hyperplasia, lymphoid 3 (17%) 2 (10%) 1 (6%) Lymph node, mandibular (76) (77) (81) (83) Hemorrhage 3 (4%) 2 (3%) 1 (1%) 1 (1%) Hyperplasia, lymphoid 1 (1%) 1 (1%) 1 (1%) 4 (5%) Infiltration cellular, histiocyte 2 (2%) Infiltration cellular, mixed cell 1 (1%) Lymph node, mesenteric (71) (84) (80) (83) Angiectasis 1 (1%) Erythrophagocytosis 1 (1%) 1 (1%) Hemorrhage 1 (1%) 4 (5%) 2 (3%) 1 (1%) Hyperplasia, lymphoid 1 (1%) 10 (12%) 3 (4%) 3 (4%) Infiltration cellular, histiocyte 3 (4%) 8 (10%) 6 (8%) 4 (5%) Infiltration cellular, plasma cell 2 (2%) Spleen (86) (87) (89) (87) Atrophy 1 (1%) Extramedullary hematopoiesis 20 (23%) 15 (17%) 19 (21%) 11 (13%) Hyperplasia, lymphoid 11 (13%) 7 (8%) 13 (15%) 10 (11%) Capsule, fibrosis 1 (1%) Capsule, inflammation, chronic active 1 (1%) Thymus (85) (80) (84) (86) Atrophy 5 (6%) 3 (4%) 8 (10%) 1 (1%) Cyst 2 (2%) 2 (3%) 7 (8%) 2 (2%) Hemorrhage 1 (1%) 1 (1%) Hyperplasia, lymphoid 1 (1%) 2 (2%) 2 (2%) Infiltration cellular, histiocyte 1 (1%) Integumentary System Mammary gland (85) (88) (88) (84) Hyperplasia, focal 1 (1%) 1 (1%) Hyperplasia, diffuse 1 (1%) 1 (1%) 1 (1%) 1 (1%) Duct, dilation 1 (1%) 1 (1%) 2 (2%) 1 (1%) Skin (90) (90) (90) (90) Inflammation, chronic 1 (1%) Ulcer 2 (2%) 2 (2%) 2 (2%) 2 (2%) Epidermis, hyperplasia, multifocal 1 (1%) Hair follicle, atrophy 2 (2%) 1 (1%) 4 (4%) 8 (9%) Subcutaneous tissue, inflammation, chronic 1 (1%) Musculoskeletal System Bone (90) (90) (89) (90) Decreased bone 1 (1%) Fibro-osseous lesion 11 (12%) 6 (7%) 4 (4%) 3 (3%) Increased bone 1 (1%) 1 (1%) Periosteum, vertebra, inflammation, granulomatous 1 (1%) B-18 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE B4 Summary of the Incidence of Nonneoplastic Lesions in Female Mice Exposed to GSM-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Musculoskeletal System (continued) Skeletal muscle (89) (90) (90) (90) Degeneration 2 (2%) 1 (1%) Infiltration cellular, lymphocyte 16 (18%) 5 (6%) 10 (11%) 16 (18%) Inflammation, chronic active 1 (1%) Mineral 1 (1%) Arteriole, inflammation, chronic 2 (2%) Nervous System Brain (87) (90) (90) (90) Cyst, squamous 2 (2%) Hemorrhage 2 (2%) 3 (3%) Hydrocephalus 1 (1%) Inflammation, acute 1 (1%) Inflammation, chronic 1 (1%) Mineral 80 (92%) 78 (87%) 77 (86%) 78 (87%) Necrosis 1 (1%) 1 (1%) 1 (1%) 1 (1%) Artery, meninges, inflammation, chronic active 5 (6%) 3 (3%) 2 (2%) Brain trigeminal ganglion (75) (74) (80) (79) Nerve trigeminal (56) (58) (53) (35) Peripheral nerve (0) (0) (1) (0) Peripheral nerve, sciatic (88) (87) (88) (88) Axon, degeneration 12 (14%) 6 (7%) 7 (8%) 6 (7%) Spinal cord (90) (90) (90) (90) Cyst, squamous 1 (1%) Necrosis 3 (3%) Artery, meninges, inflammation, chronic active 5 (6%) 1 (1%) 2 (2%) Respiratory System Larynx (0) (0) (2) (0) Lung (90) (90) (90) (90) Congestion 2 (2%) 2 (2%) 1 (1%) Hemorrhage 4 (4%) 1 (1%) 3 (3%) 3 (3%) Hyperplasia, lymphoid 1 (1%) 1 (1%) Infiltration cellular, histiocyte 1 (1%) 2 (2%) Infiltration cellular, lymphocyte 3 (3%) 1 (1%) 2 (2%) 3 (3%) Infiltration cellular, mononuclear cell 1 (1%) Inflammation, acute 1 (1%) Inflammation, chronic 1 (1%) Inflammation, chronic active 1 (1%) Alveolar epithelium, hyperplasia, focal 1 (1%) 1 (1%) 1 (1%) 3 (3%) Serosa, inflammation, chronic 1 (1%) Mediastinum (2) (0) (0) (0) Nose (89) (90) (90) (90) Inflammation, acute 1 (1%) Respiratory epithelium, accumulation, hyaline droplet 1 (1%) Respiratory epithelium, hyperplasia 1 (1%) Vomeronasal organ, cyst 1 (1%) Pleura (0) (0) (1) (0) Trachea (90) (89) (90) (90) GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 B-19 Peer Review Draft NOT FOR ATTRIBUTION TABLE B4 Summary of the Incidence of Nonneoplastic Lesions in Female Mice Exposed to GSM-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Special Senses System Ear (0) (0) (1) (0) Eye (89) (88) (90) (90) Phthisis bulbi 1 (1%) Anterior chamber, inflammation, acute 1 (1%) Bilateral, retina, hemorrhage 1 (1%) Cornea, inflammation, acute 1 (1%) 1 (1%) Cornea, inflammation, chronic 2 (2%) Cornea, inflammation, chronic active 1 (1%) Cornea, necrosis 1 (1%) 1 (1%) Harderian gland (89) (90) (90) (87) Hyperplasia, focal 1 (1%) Infiltration cellular, lymphocyte 58 (65%) 68 (76%) 69 (77%) 63 (72%) Inflammation, chronic active 1 (1%) Lacrimal gland (0) (1) (2) (0) Zymbal’s gland (0) (0) (1) (0) Urinary System Kidney (89) (87) (89) (88) Cyst 1 (1%) Glomerulopathy, hyaline 2 (2%) Hemorrhage 1 (1%) Infarct 14 (16%) 19 (22%) 20 (22%) 14 (16%) Inflammation, acute 1 (1%) Metaplasia, osseous 2 (2%) 2 (2%) 2 (2%) 2 (2%) Nephropathy, chronic progressive 8 (9%) 15 (17%) 19 (21%) 14 (16%) Bilateral, infarct 1 (1%) Interstitium, infiltration cellular, lymphocyte 63 (71%) 60 (69%) 65 (73%) 56 (64%) Papilla, mineral 2 (2%) 1 (1%) 1 (1%) Pelvis, dilatation 1 (1%) Pelvis, mineral 1 (1%) Pelvis, necrosis 1 (1%) Renal tubule, dilation 1 (1%) 1 (1%) 1 (1%) Renal tubule, hyaline droplet 1 (1%) Renal tubule, mineral 1 (1%) 1 (1%) Renal tubule, vacuolization cytoplasmic 1 (1%) Ureter (0) (0) (1) (0) Urethra (0) (0) (1) (0) Urinary bladder (86) (87) (86) (86) Angiectasis 2 (2%) Infiltration cellular, lymphocyte 62 (72%) 67 (77%) 65 (76%) 68 (79%) Inflammation, acute 1 (1%) Arteriole, inflammation, chronic 1 (1%) Urothelium, hyperplasia 1 (1%) B-20 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft C-1 Peer Review Draft NOT FOR ATTRIBUTION APPENDIX C SUMMARY OF LESIONS IN MALE MICE EXPOSED TO CDMA-MODULATED CELL PHONE RFR FOR 2 YEARS TABLE C1 Summary of the Incidence of Neoplasms in Male Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years.........................................................C-2 TABLE C2 Statistical Analysis of Primary Neoplasms in Male Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years.........................................................C-8 TABLE C3 Historical Incidence of Liver Neoplasms in Control Male B6C3F1/N Mice ...............................C-10 TABLE C4 Summary of the Incidence of Nonneoplastic Lesions in Male Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years.......................................................C-11 C-2 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE C1 Summary of the Incidence of Neoplasms in Male Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Yearsa Sham Control 2.5 W/kg 5 W/kg 10 W/kg Disposition Summary Animals initially in study 105 106 105 105 14-Week interim evaluation 15 15 15 15 Early deaths Accidental death 1 Moribund 8 2 5 3 Natural deaths 16 6 13 16 Survivors Terminal euthanasia 66 83 71 71 Animals examined microscopically 100 101 100 100 Systems Examined at 14 Weeks with No Neoplasms Observed Alimentary System Cardiovascular System Endocrine System General Body System Genital System Hematopoietic System Integumentary System Musculoskeletal System Nervous System Respiratory System Special Senses System Urinary System 2-Year Study Alimentary System Esophagus (88) (91) (89) (88) Gallbladder (73) (80) (75) (76) Intestine large, cecum (81) (87) (81) (80) Adenoma 1 (1%) Intestine large, colon (84) (88) (84) (81) Adenocarcinoma 1 (1%) Intestine large, rectum (84) (89) (85) (85) Intestine small, duodenum (77) (86) (81) (80) Adenocarcinoma 1 (1%) Intestine small, ileum (81) (88) (83) (81) Adenoma 1 (1%) Intestine small, jejunum (79) (87) (81) (82) Adenocarcinoma 2 (3%) 1 (1%) 2 (2%) Adenoma 1 (1%) Hepatocellular carcinoma, metastatic, liver 1 (1%) GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 C-3 Peer Review Draft NOT FOR ATTRIBUTION TABLE C1 Summary of the Incidence of Neoplasms in Male Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Alimentary System (continued) Liver (90) (89) (90) (90) Hemangiosarcoma 1 (1%) 4 (4%) 2 (2%) 1 (1%) Hepatoblastoma 6 (7%) 6 (7%) 15 (17%) 7 (8%) Hepatoblastoma, multiple 1 (1%) Hepatocellular adenoma 25 (28%) 23 (26%) 22 (24%) 36 (40%) Hepatocellular adenoma, multiple 27 (30%) 43 (48%) 33 (37%) 26 (29%) Hepatocellular carcinoma 26 (29%) 13 (15%) 18 (20%) 24 (27%) Hepatocellular carcinoma, multiple 2 (2%) 5 (6%) 7 (8%) 7 (8%) Hepatocholangiocarcinoma 1 (1%) 2 (2%) Malignant fibrous histiocytoma, metastatic, skin 1 (1%) Sarcoma, metastatic, skeletal muscle 1 (1%) Mesentery (12) (9) (18) (16) Hemangiosarcoma 1 (8%) Hepatoblastoma, metastatic, liver 1 (6%) Malignant fibrous histiocytoma, metastatic, skin 1 (8%) Fat, hepatocholangiocarcinoma, metastatic, liver 1 (8%) Fat, lipoma 1 (8%) 2 (11%) Pancreas (87) (88) (88) (88) Hepatocholangiocarcinoma, metastatic, liver 1 (1%) Salivary glands (90) (90) (89) (90) Stomach, forestomach (88) (89) (86) (87) Squamous cell papilloma 1 (1%) Stomach, glandular (87) (88) (87) (87) Malignant fibrous histiocytoma, metastatic, skin 1 (1%) Tooth (27) (15) (17) (23) Cardiovascular System Aorta (89) (88) (90) (89) Alveolar/bronchiolar carcinoma, metastatic, lung 1 (1%) Blood vessel (1) (1) (0) (0) Heart (90) (91) (90) (90) Alveolar/bronchiolar carcinoma, metastatic, lung 1 (1%) 1 (1%) Hemangioma 1 (1%) Hepatocholangiocarcinoma, metastatic, liver 1 (1%) 1 (1%) Sarcoma, metastatic, skeletal muscle 1 (1%) C-4 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE C1 Summary of the Incidence of Neoplasms in Male Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Endocrine System Adrenal cortex (90) (89) (90) (89) Bilateral, malignant fibrous histiocytoma, metastatic, skin 1 (1%) Bilateral, subcapsular, adenoma 1 (1%) 1 (1%) Subcapsular, adenoma 1 (1%) 3 (3%) 4 (4%) Subcapsular, carcinoma 1 (1%) Adrenal medulla (90) (89) (88) (89) Pheochromocytoma benign 1 (1%) Islets, pancreatic (88) (90) (89) (89) Adenoma 1 (1%) Carcinoma 1 (1%) Parathyroid gland (68) (57) (66) (65) Pituitary gland (86) (84) (89) (83) Pars distalis, adenoma 2 (2%) Pars distalis, carcinoma 1 (1%) Thyroid gland (89) (89) (88) (87) Follicular cell, adenoma 1 (1%) 1 (1%) 1 (1%) General Body System Peritoneum (1) (0) (0) (0) Hepatocholangiocarcinoma, metastatic, liver 1 (100%) Tissue NOS (0) (1) (0) (0) Fat, hemangiosarcoma 1 (100%) Genital System Coagulating gland (2) (3) (0) (1) Epididymis (90) (91) (90) (90) Preputial gland (89) (89) (89) (89) Prostate (90) (86) (90) (88) Seminal vesicle (90) (90) (90) (90) Fibroma 1 (1%) Malignant fibrous histiocytoma, metastatic, skin 1 (1%) Testis (90) (91) (88) (90) Interstitial cell, adenoma 2 (2%) 2 (2%) Hematopoietic System Bone marrow (90) (90) (90) (90) Hemangiosarcoma 1 (1%) Lymph node (6) (6) (11) (10) Axillary, hepatocholangiocarcinoma, metastatic, liver 1 (17%) Axillary, squamous cell carcinoma, metastatic, skin 1 (9%) Bronchial, sarcoma, metastatic, skeletal muscle 1 (10%) Lumbar, squamous cell carcinoma, metastatic, skin 1 (9%) Pancreatic, hepatoblastoma, metastatic, liver 1 (9%) Lymph node, mandibular (72) (70) (63) (64) GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 C-5 Peer Review Draft NOT FOR ATTRIBUTION TABLE C1 Summary of the Incidence of Neoplasms in Male Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Hematopoietic System (continued) Lymph node, mesenteric (85) (88) (86) (85) Hemangioma 1 (1%) Hepatoblastoma, metastatic, liver 1 (1%) Malignant fibrous histiocytoma, metastatic, skin 1 (1%) Spleen (87) (89) (87) (86) Hemangiosarcoma 2 (2%) 1 (1%) 2 (2%) Thymus (75) (76) (80) (81) Integumentary System Mammary gland (2) (1) (0) (3) Skin (90) (91) (90) (90) Lipoma 1 (1%) Pilomatrixoma 1 (1%) Squamous cell carcinoma 1 (1%) Subcutaneous tissue, hemangiosarcoma 1 (1%) Subcutaneous tissue, lipoma 1 (1%) 1 (1%) Subcutaneous tissue, malignant fibrous histiocytoma 1 (1%) 1 (1%) 2 (2%) Musculoskeletal System Bone (90) (91) (90) (90) Skeletal muscle (90) (91) (90) (90) Alveolar/bronchiolar carcinoma, metastatic, lung 1 (1%) 1 (1%) Hepatoblastoma, metastatic, liver 1 (1%) Hepatocellular carcinoma, metastatic, liver 1 (1%) Hepatocholangiocarcinoma, metastatic, liver 1 (1%) 1 (1%) Malignant fibrous histiocytoma, metastatic, skin 1 (1%) Sarcoma 1 (1%) 1 (1%) Squamous cell carcinoma, metastatic, skin 1 (1%) Nervous System Brain (90) (91) (90) (90) Carcinoma, metastatic, pituitary gland 1 (1%) Hepatocholangiocarcinoma, metastatic, liver 1 (1%) Brain trigeminal ganglion (69) (79) (80) (80) Nerve trigeminal (67) (57) (43) (55) Peripheral nerve, sciatic (89) (91) (87) (88) Spinal cord (90) (91) (90) (90) C-6 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE C1 Summary of the Incidence of Neoplasms in Male Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Respiratory System Lung (90) (91) (90) (90) Alveolar/bronchiolar adenoma 11 (12%) 8 (9%) 14 (16%) 12 (13%) Alveolar/bronchiolar adenoma, multiple 2 (2%) 2 (2%) Alveolar/bronchiolar carcinoma 11 (12%) 13 (14%) 11 (12%) 11 (12%) Alveolar/bronchiolar carcinoma, multiple 2 (2%) Hepatoblastoma, metastatic, liver 1 (1%) 2 (2%) Hepatocellular carcinoma, metastatic, liver 11 (12%) 4 (4%) 9 (10%) 11 (12%) Hepatocholangiocarcinoma, metastatic, liver 1 (1%) 1 (1%) Sarcoma, metastatic, skeletal muscle 1 (1%) Squamous cell carcinoma, metastatic, skin 1 (1%) Nose (90) (91) (90) (90) Trachea (90) (90) (90) (89) Special Senses System Eye (90) (91) (89) (90) Harderian gland (88) (91) (90) (88) Adenocarcinoma 3 (3%) 3 (3%) 1 (1%) 2 (2%) Adenoma 6 (7%) 4 (4%) 4 (4%) 4 (5%) Urinary System Kidney (90) (89) (90) (90) Hepatocellular carcinoma, metastatic, liver 1 (1%) Hepatocholangiocarcinoma, metastatic, liver 1 (1%) Malignant fibrous histiocytoma, metastatic, skin 1 (1%) Sarcoma, metastatic, skeletal muscle 1 (1%) Renal tubule, adenoma 1 (1%) Ureter (0) (0) (1) (0) Urinary bladder (87) (90) (90) (89) Systemic Lesions Multiple organsb (90) (91) (90) (90) Histiocytic sarcoma 2 (2%) 1 (1%) 2 (2%) Leukemia granulocytic 1 (1%) Lymphoma malignant 6 (7%) 3 (3%) 5 (6%) 4 (4%) Mast cell tumor 1 (1%) GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 C-7 Peer Review Draft NOT FOR ATTRIBUTION TABLE C1 Summary of the Incidence of Neoplasms in Male Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Neoplasm Summary Total animals with primary neoplasmsc 2-Year study 79 80 82 94 Total primary neoplasms 2-Year study 144 139 157 155 Total animals with benign neoplasms 2-Year study 61 70 63 70 Total benign neoplasms 2-Year study 77 85 87 89 Total animals with malignant neoplasms 2-Year study 49 42 58 50 Total malignant neoplasms 2-Year study 66 54 70 66 Total animals with metastatic neoplasms 2-Year study 14 6 14 13 Total metastatic neoplasms 2-Year study 34 6 21 19 Total animals with uncertain neoplasmsbenign or malignant 2-Year study 1 Total uncertain neoplasms 2-Year study 1 a Number of animals examined microscopically at the site and the number of animals with neoplasm b Number of animals with any tissue examined microscopically c Primary neoplasms: all neoplasms except metastatic neoplasms C-8 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE C2 Statistical Analysis of Primary Neoplasms in Male Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg Harderian Gland: Adenoma Overall ratea 6/90 (7%) 4/91 (4%) 4/90 (4%) 4/90 (4%) Adjusted rateb 7.5% 4.6% 4.7% 4.8% Terminal ratec 6/66 (9%) 4/83 (5%) 4/71 (6%) 3/71 (4%) First incidence (days) 729 (T) 729 (T) 729 (T) 707 Poly-3 testd P=0.342N P=0.322N P=0.342N P=0.353N Harderian Gland: Adenoma or Carcinoma Overall rate 9/90 (10%) 7/91 (8%) 5/90 (6%) 6/90 (7%) Adjusted rate 11.2% 8.0% 5.9% 7.2% Terminal rate 8/66 (12%) 7/83 (8%) 5/71 (7%) 5/71 (7%) First incidence (days) 690 729 (T) 729 (T) 707 Poly-3 test P=0.237N P=0.331N P=0.176N P=0.273N Liver: Hepatocellular Adenoma Overall rate 52/90 (58%) 66/89 (74%) 55/90 (61%) 62/90 (69%) Adjusted rate 62.3% 75.4% 64.9% 72.7% Terminal rate 45/66 (68%) 64/83 (77%) 51/71 (72%) 54/71 (76%) First incidence (days) 393 625 656 478 Poly-3 test P=0.199 P=0.043 P=0.428 P=0.096 Liver: Hepatocellular Carcinoma Overall rate 28/90 (31%) 18/89 (20%) 25/90 (28%) 31/90 (34%) Adjusted rate 34.2% 20.6% 29.0% 36.2% Terminal rate 18/66 (27%) 16/83 (19%) 18/71 (25%) 22/71 (31%) First incidence (days) 608 629 559 461 Poly-3 test P=0.177 P=0.033N P=0.287N P=0.459 Liver: Hepatocellular Adenoma or Carcinoma Overall rate 67/90 (74%) 70/89 (79%) 66/90 (73%) 73/90 (81%) Adjusted rate 79.1% 79.6% 76.6% 83.3% Terminal rate 51/66 (77%) 67/83 (81%) 58/71 (82%) 59/71 (83%) First incidence (days) 393 625 559 461 Poly-3 test P=0.278 P=0.543 P=0.412N P=0.302 Liver: Hepatoblastoma Overall rate 6/90 (7%) 6/89 (7%) 16/90 (18%) 7/90 (8%) Adjusted rate 7.5% 6.9% 18.9% 8.5% Terminal rate 5/66 (8%) 6/83 (7%) 14/71 (20%) 7/71 (10%) First incidence (days) 711 729 (T) 679 729 (T) Poly-3 test P=0.328 P=0.562N P=0.026 P=0.523 Liver: Hepatocellular Carcinoma or Hepatoblastoma Overall rate 32/90 (36%) 22/89 (25%) 37/90 (41%) 35/90 (39%) Adjusted rate 39.1% 25.1% 42.8% 40.9% Terminal rate 22/66 (33%) 20/83 (24%) 28/71 (39%) 26/71 (37%) First incidence (days) 608 629 559 461 Poly-3 test P=0.159 P=0.036N P=0.370 P=0.472 Liver: Hepatocellular Adenoma, Hepatocellular Carcinoma, or Hepatoblastoma Overall rate 68/90 (76%) 70/89 (79%) 69/90 (77%) 75/90 (83%) Adjusted rate 80.3% 79.6% 79.8% 85.6% Terminal rate 52/66 (79%) 67/83 (81%) 59/71 (83%) 61/71 (86%) First incidence (days) 393 625 559 461 Poly-3 test P=0.175 P=0.532N P=0.548N P=0.230 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 C-9 Peer Review Draft NOT FOR ATTRIBUTION TABLE C2 Statistical Analysis of Primary Neoplasms in Male Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg Lung: Alveolar/bronchiolar Adenoma Overall rate 13/90 (14%) 8/91 (9%) 16/90 (18%) 12/90 (13%) Adjusted rate 16.0% 9.1% 19.0% 14.4% Terminal rate 9/66 (14%) 7/83 (8%) 15/71 (21%) 11/71 (16%) First incidence (days) 488 594 727 585 Poly-3 test P=0.441 P=0.131N P=0.382 P=0.474N Lung: Alveolar/bronchiolar Carcinoma Overall rate 13/90 (14%) 13/91 (14%) 11/90 (12%) 11/90 (12%) Adjusted rate 16.1% 14.7% 12.9% 13.1% Terminal rate 12/66 (18%) 10/83 (12%) 9/71 (13%) 8/71 (11%) First incidence (days) 568 625 588 518 Poly-3 test P=0.326N P=0.486N P=0.360N P=0.375N Lung: Alveolar/bronchiolar Adenoma or Carcinoma Overall rate 23/90 (26%) 21/91 (23%) 25/90 (28%) 21/90 (23%) Adjusted rate 28.1% 23.7% 29.4% 24.9% Terminal rate 18/66 (27%) 17/83 (21%) 22/71 (31%) 17/71 (24%) First incidence (days) 488 594 588 518 Poly-3 test P=0.444N P=0.312N P=0.496 P=0.385N All Organs: Hemangiosarcoma Overall rate 2/90 (2%) 7/91 (8%) 4/90 (4%) 3/90 (3%) Adjusted rate 2.5% 8.0% 4.7% 3.6% Terminal rate 0/66 (0%) 7/83 (8%) 4/71 (6%) 3/71 (4%) First incidence (days) 702 729 (T) 729 (T) 729 (T) Poly-3 test P=0.483N P=0.107 P=0.362 P=0.513 All Organs: Hemangioma or Hemangiosarcoma Overall rate 3/90 (3%) 8/91 (9%) 4/90 (4%) 3/90 (3%) Adjusted rate 3.7% 9.2% 4.7% 3.6% Terminal rate 1/66 (2%) 8/83 (10%) 4/71 (6%) 3/71 (4%) First incidence (days) 702 729 (T) 729 (T) 729 (T) Poly-3 test P=0.325N P=0.135 P=0.526 P=0.647N All Organs: Malignant Lymphoma Overall rate 6/90 (7%) 3/91 (3%) 5/90 (6%) 4/90 (4%) Adjusted rate 7.3% 3.4% 5.9% 4.8% Terminal rate 4/66 (6%) 3/83 (4%) 3/71 (4%) 4/71 (6%) First incidence (days) 263 729 (T) 674 729 (T) Poly-3 test P=0.413N P=0.217N P=0.478N P=0.366N (T) Terminal euthanasia a Number of neoplasm-bearing animals/number of animals examined. Denominator is number of animals examined microscopically for liver and lung; for other tissues, denominator is number of animals necropsied. b Poly-3 estimated neoplasm incidence after adjustment for intercurrent mortality c Observed incidence at terminal euthanasia d Beneath the sham control incidence is the P value associated with the trend test. Beneath the exposed group incidence are the P values corresponding to pairwise comparisons between the sham controls and that exposed group. The Poly-3 test accounts for differential mortality in animals that do not reach terminal euthanasia. A negative trend or a lower incidence in an exposure group is indicated by N. C-10 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE C3 Historical Incidence of Liver Neoplasms in Control Male B6C3F1/N Micea Hepatocellular Adenoma Hepatocellular Carcinoma Hepatoblastoma Hepatocellular Adenoma, Hepatocellular Carcinoma, or Hepatoblastoma Overall Historical Incidence: All Routes Total (%) 308/589 (52.3%) 164/589 (27.8%) 19/589 (3.2%) 408/589 (69.3%) Mean ± standard deviation 51.9% ± 10.3% 27.6% ± 8.3% 3.0% ± 2.2% 68.8% ± 8.6% Range 34%-70% 16%-42% 0%-7% 53%-80% a Data as of August 2017 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 C-11 Peer Review Draft NOT FOR ATTRIBUTION TABLE C4 Summary of the Incidence of Nonneoplastic Lesions in Male Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Yearsa Sham Control 2.5 W/kg 5 W/kg 10 W/kg Disposition Summary Animals initially in study 105 106 105 105 14-Week interim evaluation 15 15 15 15 Early deaths Accidental death 1 Moribund 8 2 5 3 Natural deaths 16 6 13 16 Survivors Terminal euthanasia 66 83 71 71 Animals examined microscopically 100 101 100 100 14-Week Interim Evaluation Alimentary System Liver (10) (10) (10) (10) Infiltration cellular, lymphocyte 1 (10%) Infiltration cellular, mixed cell, multifocal 2 (20%) Infiltration cellular, mixed cell 1 (10%) Inflammation, focal 1 (10%) Salivary glands (10) (10) (10) (10) Infiltration cellular, lymphocyte 1 (10%) Endocrine System Thyroid gland (10) (9) (10) (10) Infiltration cellular, lymphocyte 1 (10%) Hematopoietic System Lymph node, mandibular (5) (8) (9) (10) Hemorrhage 1 (11%) 2 (20%) Nervous System Brain (10) (10) (10) (10) Hemorrhage 1 (10%) Respiratory System Lung (10) (10) (10) (10) Congestion 1 (10%) Hemorrhage 2 (20%) Infiltration cellular, mixed cell 1 (10%) Urinary System Kidney (10) (10) (10) (10) Nephropathy, chronic progressive 1 (10%) 1 (10%) 1 (10%) Interstitium, infiltration cellular, lymphocyte 2 (20%) 2 (20%) 3 (30%) 1 (10%) a Number of animals examined microscopically at the site and the number of animals with lesion C-12 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE C4 Summary of the Incidence of Nonneoplastic Lesions in Male Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 14-Week Interim Evaluation (continued) Systems Examined with No Lesions Observed Cardiovascular System General Body System Genital System Integumentary System Musculoskeletal System Special Senses System 2-Year Study Alimentary System Esophagus (88) (91) (89) (88) Infiltration cellular, lymphocyte 1 (1%) Gallbladder (73) (80) (75) (76) Cyst 1 (1%) Intestine large, cecum (81) (87) (81) (80) Intestine large, colon (84) (88) (84) (81) Intestine large, rectum (84) (89) (85) (85) Intestine small, duodenum (77) (86) (81) (80) Peyer’s patch, hyperplasia, lymphoid 1 (1%) Intestine small, ileum (81) (88) (83) (81) Peyer’s patch, hyperplasia, lymphoid 1 (1%) 1 (1%) 1 (1%) 3 (4%) Peyer’s patch, infiltration cellular, plasma cell 1 (1%) Intestine small, jejunum (79) (87) (81) (82) Inflammation, granulomatous 1 (1%) Epithelium, cyst 1 (1%) Peyer’s patch, hyperplasia, lymphoid 1 (1%) 2 (2%) 3 (4%) Peyer’s patch, infiltration, cellular, polymorphonuclear 1 (1%) Serosa, inflammation, granulomatous 1 (1%) Liver (90) (89) (90) (90) Angiectasis 1 (1%) Basophilic focus 1 (1%) 2 (2%) 3 (3%) 2 (2%) Clear cell focus 28 (31%) 49 (55%) 35 (39%) 31 (34%) Congestion, chronic 1 (1%) Eosinophilic focus 4 (4%) 5 (6%) 2 (2%) 5 (6%) Extramedullary hematopoiesis 2 (2%) 1 (1%) 2 (2%) Fatty change 37 (41%) 51 (57%) 26 (29%) 33 (37%) Fibrosis 1 (1%) Hemorrhage 1 (1%) Infiltration cellular, lymphocyte 2 (2%) 1 (1%) 3 (3%) Infiltration cellular, mixed cell 1 (1%) 1 (1%) Infiltration cellular, polymorphonuclear 1 (1%) Inflammation, focal 1 (1%) 1 (1%) 1 (1%) Inflammation, chronic active 2 (2%) 1 (1%) Metaplasia 1 (1%) Mineral 1 (1%) Mixed cell focus 2 (2%) 2 (2%) 3 (3%) 1 (1%) Necrosis 6 (7%) 2 (2%) 9 (10%) 10 (11%) Bile duct, cyst 1 (1%) Capsule, fibrosis 1 (1%) 1 (1%) Hepatocyte, degeneration 1 (1%) Vein, inflammation, chronic active 1 (1%) GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 C-13 Peer Review Draft NOT FOR ATTRIBUTION TABLE C4 Summary of the Incidence of Nonneoplastic Lesions in Male Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Alimentary System (continued) Mesentery (12) (9) (18) (16) Artery, inflammation, chronic active 1 (11%) 1 (6%) Artery, thrombus 1 (6%) Fat, inflammation, granulomatous 1 (6%) 1 (6%) Fat, necrosis 8 (67%) 8 (89%) 14 (78%) 12 (75%) Pancreas (87) (88) (88) (88) Hemorrhage 1 (1%) Infiltration cellular, lymphocyte 3 (3%) 2 (2%) 2 (2%) 4 (5%) Inflammation, granulomatous 1 (1%) Artery, inflammation, chronic 1 (1%) Duct, cyst 1 (1%) 1 (1%) Duct, fibrosis 1 (1%) Salivary glands (90) (90) (89) (90) Infiltration cellular, lymphocyte 58 (64%) 67 (74%) 68 (76%) 61 (68%) Stomach, forestomach (88) (89) (86) (87) Cyst, squamous 1 (1%) 3 (3%) Inflammation, acute 1 (1%) Ulcer 1 (1%) Epithelium, hyperplasia, focal 3 (3%) 3 (3%) Epithelium, hyperplasia, diffuse 1 (1%) Stomach, glandular (87) (88) (87) (87) Hemorrhage 1 (1%) Mineral 2 (2%) Epithelium, hyperplasia, focal 1 (1%) Tooth (27) (15) (17) (23) Dysplasia 26 (96%) 15 (100%) 16 (94%) 22 (96%) Inflammation, suppurative 2 (7%) 1 (7%) Inflammation, chronic active 1 (6%) 2 (9%) Cardiovascular System Aorta (89) (88) (90) (89) Inflammation, chronic 1 (1%) Blood vessel (1) (1) (0) (0) Inflammation, chronic 1 (100%) 1 (100%) Heart (90) (91) (90) (90) Bacteria 1 (1%) 1 (1%) Cardiomyopathy 10 (11%) 6 (7%) 6 (7%) 10 (11%) Inflammation, acute 1 (1%) 1 (1%) 1 (1%) Inflammation, chronic active 2 (2%) 1 (1%) Mineral 1 (1%) Thrombus 1 (1%) 1 (1%) 1 (1%) Artery, inflammation, chronic active 1 (1%) 3 (3%) 1 (1%) Endocardium, mineral 1 (1%) Endothelium, hyperplasia 2 (2%) 1 (1%) Epicardium, inflammation, chronic 1 (1%) Epicardium, mineral 1 (1%) Intima, vein, hyperplasia 2 (2%) Myocardium, infiltration cellular, lymphocyte 2 (2%) 2 (2%) Myocarcium, inflammation, chronic active 1 (1%) Myocardium, mineral 2 (2%) 2 (2%) 1 (1%) Myocardium, necrosis 1 (1%) 1 (1%) Valve, inflammation, chronic active 1 (1%) Vein, inflammation, chronic active 1 (1%) C-14 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE C4 Summary of the Incidence of Nonneoplastic Lesions in Male Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Endocrine System Adrenal cortex (90) (89) (90) (89) Accessory adrenal cortical nodule 1 (1%) Angiectasis 1 (1%) Hemorrhage 1 (1%) Hyperplasia, focal 3 (3%) 3 (3%) 3 (3%) 1 (1%) Hypertrophy, focal 2 (2%) 8 (9%) 3 (3%) Vacuolization cytoplasmic, focal 1 (1%) Bilateral, hyperplasia, focal 1 (1%) Bilateral, hypertrophy, focal 1 (1%) 1 (1%) 1 (1%) Subcapsular, hyperplasia 69 (77%) 73 (82%) 74 (82%) 66 (74%) Adrenal medulla (90) (89) (88) (89) Hyperplasia 1 (1%) Islets, pancreatic (88) (90) (89) (89) Hyperplasia 18 (20%) 13 (14%) 14 (16%) 11 (12%) Infiltration cellular, lymphocyte 2 (2%) 1 (1%) 4 (4%) Parathyroid gland (68) (57) (66) (65) Cyst 1 (2%) 1 (2%) Pituitary gland (86) (84) (89) (83) Pars distalis, angiectasis 1 (1%) Pars distalis, cyst 3 (3%) 1 (1%) 1 (1%) 2 (2%) Pars distalis, hyperplasia, focal 1 (1%) Thyroid gland (89) (89) (88) (87) Infiltration cellular, lymphocyte 1 (1%) 1 (1%) Arteriole, inflammation, chronic active 1 (1%) Epithelium, follicle, hyperplasia, focal 1 (1%) General Body System Peritoneum (1) (0) (0) (0) Tissues NOS (0) (1) (0) (0) Genital System Coagulating gland (2) (3) (0) (1) Cyst 2 (100%) 3 (100%) 1 (100%) Infiltration cellular, lymphocyte 1 (33%) Inflammation, chronic 1 (33%) Epididymis (90) (91) (90) (90) Granuloma sperm 1 (1%) 2 (2%) Infiltration cellular, lymphocyte 29 (32%) 26 (29%) 26 (29%) 32 (36%) Infiltration cellular, mononuclear cell 1 (1%) Artery, inflammation, chronic 1 (1%) 1 (1%) Preputial gland (89) (89) (89) (89) Atrophy 1 (1%) Infiltration cellular, lymphocyte 43 (48%) 40 (45%) 39 (44%) 38 (43%) Inflammation, suppurative 1 (1%) Inflammation, chronic active 1 (1%) 3 (3%) 3 (3%) 1 (1%) Bilateral, inflammation, chronic active 1 (1%) Bilateral, duct, dilation 6 (7%) 4 (4%) 5 (6%) 3 (3%) Duct, dilation 10 (11%) 10 (11%) 5 (6%) 5 (6%) Duct, inflammation, chronic active 1 (1%) Duct, necrosis 1 (1%) GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 C-15 Peer Review Draft NOT FOR ATTRIBUTION TABLE C4 Summary of the Incidence of Nonneoplastic Lesions in Male Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Genital System (continued) Prostate (90) (86) (90) (88) Infiltration cellular, lymphocyte 4 (4%) 8 (9%) 10 (11%) 9 (10%) Inflammation, acute 1 (1%) Inflammation, chronic active 1 (1%) Arteriole, inflammation, chronic 1 (1%) Seminal vesicle (90) (90) (90) (90) Dilation 4 (4%) 9 (10%) 4 (4%) 2 (2%) Inflammation, chronic active 1 (1%) 1 (1%) Bilateral, dilation 27 (30%) 19 (21%) 26 (29%) 14 (16%) Testis (90) (91) (88) (90) Bilateral, germinal epithelium, atrophy 1 (1%) Germ cell, degeneration 2 (2%) 2 (2%) 4 (5%) 7 (8%) Seminiferous tubule, necrosis 1 (1%) Hematopoietic System Bone marrow (90) (90) (90) (90) Hypercellularity 3 (3%) 2 (2%) 3 (3%) Myeloid cell, hypercellularity 1 (1%) Lymph node (6) (6) (11) (10) Bronchial, hyperplasia, lymphoid 2 (20%) Iliac, erythrophagocytosis 1 (17%) Iliac, hemorrhage 1 (9%) Iliac, hyperplasia, lymphoid 2 (33%) 4 (36%) Iliac, infiltration cellular, histiocyte 1 (10%) Iliac, pigment 2 (18%) 1 (10%) Inguinal, hyperplasia, lymphoid 2 (20%) Mediastinal, hyperplasia, lymphoid 2 (33%) 1 (9%) 2 (20%) Renal, hemorrhage 1 (17%) Renal, pigment 1 (9%) Lymph node, mandibular (72) (70) (63) (64) Hemorrhage 1 (2%) 1 (2%) Hyperplasia, lymphoid 2 (3%) 1 (2%) 2 (3%) Infiltration cellular, histiocyte 1 (1%) 1 (1%) 1 (2%) 2 (3%) Infiltration cellular, plasma cell 1 (1%) Lymph node, mesenteric (85) (88) (86) (85) Erythrophagocytosis 1 (1%) 1 (1%) 1 (1%) 1 (1%) Hemorrhage 10 (12%) 21 (24%) 16 (19%) 14 (16%) Hyperplasia, lymphoid 4 (5%) 3 (3%) 5 (6%) 6 (7%) Infiltration cellular, histiocyte 8 (9%) 7 (8%) 5 (6%) 5 (6%) Infiltration cellular, mixed cell 1 (1%) Infiltration cellular, plasma cell 1 (1%) 1 (1%) Spleen (87) (89) (87) (86) Extramedullary hematopoiesis 15 (17%) 7 (8%) 21 (24%) 16 (19%) Hyperplasia, lymphoid 5 (6%) 4 (4%) 3 (3%) 9 (10%) Thymus (75) (76) (80) (81) Atrophy 11 (15%) 3 (4%) 8 (10%) 5 (6%) Cyst 11 (15%) 17 (22%) 19 (24%) 19 (23%) Hemorrhage 1 (1%) 1 (1%) Hyperplasia, lymphoid 2 (3%) C-16 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE C4 Summary of the Incidence of Nonneoplastic Lesions in Male Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Integumentary System Mammary gland (2) (1) (0) (3) Skin (90) (91) (90) (90) Infiltration cellular, mixed cell 1 (1%) Inflammation, chronic 1 (1%) Ulcer 2 (2%) 1 (1%) 2 (2%) 4 (4%) Epidermis, hyperplasia, focal 1 (1%) 2 (2%) Musculoskeletal System Bone (90) (91) (90) (90) Fibro-osseous lesion 1 (1%) Increased bone 1 (1%) Skeletal muscle (90) (91) (90) (90) Degeneration 1 (1%) 1 (1%) Infiltration cellular, lymphocyte 3 (3%) 1 (1%) 1 (1%) 4 (4%) Inflammation, granulomatous 1 (1%) Inflammation, acute 1 (1%) Nervous System Brain (90) (91) (90) (90) Hemorrhage 2 (2%) Infiltration cellular, lymphocyte 1 (1%) Mineral 79 (88%) 80 (88%) 77 (86%) 77 (86%) Necrosis 1 (1%) Artery, meninges, inflammation, chronic active 1 (1%) 2 (2%) 3 (3%) 1 (1%) Meninges, inflammation, chronic 1 (1%) Brain trigeminal ganglion (69) (79) (80) (80) Nerve trigeminal (67) (57) (43) (55) Peripheral nerve, sciatic (89) (91) (87) (88) Inflammation, chronic active 1 (1%) Axon, degeneration 9 (10%) 5 (5%) 4 (5%) 11 (13%) Spinal cord (90) (91) (90) (90) Degeneration 1 (1%) Necrosis 1 (1%) 1 (1%) 1 (1%) Squamous cyst 2 (2%) Artery, meninges, inflammation, chronic active 1 (1%) 2 (2%) 4 (4%) 1 (1%) Respiratory System Lung (90) (91) (90) (90) Congestion 2 (2%) 3 (3%) 2 (2%) Hemorrhage 3 (3%) 2 (2%) 4 (4%) 1 (1%) Infiltration cellular, histiocyte 6 (7%) 5 (5%) 3 (3%) 5 (6%) Infiltration cellular, lymphocyte 1 (1%) 1 (1%) 3 (3%) Infiltration, mononuclear cell 1 (1%) 3 (3%) Inflammation, granulomatous 1 (1%) Alveolar epithelium, hyperplasia, focal 6 (7%) 7 (8%) 8 (9%) 5 (6%) Bronchiole, foreign body 1 (1%) Bronchiole, inflammation, suppurative 1 (1%) GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 C-17 Peer Review Draft NOT FOR ATTRIBUTION TABLE C4 Summary of the Incidence of Nonneoplastic Lesions in Male Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Respiratory System (continued) Nose (90) (91) (90) (90) Infiltration cellular, lymphocyte 1 (1%) Inflammation, acute 1 (1%) Respiratory epithelium, accumulation, hyaline droplet 1 (1%) 1 (1%) Respiratory epithelium, hyperplasia 5 (6%) 1 (1%) Vomeronasal organ, fibrosis 1 (1%) Trachea (90) (90) (90) (89) Special Senses System Eye (90) (91) (89) (90) Atrophy 1 (1%) 1 (1%) Bilateral, cornea, inflammation, chronic active 1 (1%) Bilateral, iris, synechia 1 (1%) Cornea, edema 1 (1%) Cornea, fibrosis 1 (1%) Cornea, hyperplasia, squamous, diffuse 1 (1%) Sclera, inflammation, acute 1 (1%) Harderian gland (88) (91) (90) (88) Hemorrhage 1 (1%) Hyperplasia, focal 2 (2%) 3 (3%) 1 (1%) Infiltration cellular, lymphocyte 36 (41%) 41 (45%) 40 (44%) 38 (43%) Mineral 1 (1%) Urinary System Kidney (90) (89) (90) (90) Infarct 7 (8%) 6 (7%) 11 (12%) 7 (8%) Inflammation, suppurative 1 (1%) Inflammation, granulomatous 1 (1%) Metaplasia, osseous 3 (3%) 8 (9%) 3 (3%) 5 (6%) Mineral 3 (3%) 1 (1%) 1 (1%) Nephropathy, chronic progressive 74 (82%) 84 (94%) 81 (90%) 77 (86%) Artery, inflammation, chronic active 1 (1%) Bilateral, bacteria 1 (1%) Bilateral, infarct 1 (1%) 2 (2%) Bilateral, inflammation, acute 1 (1%) Bilateral, renal tubule, pigment 1 (1%) Glomerulus, cyst 1 (1%) 2 (2%) 1 (1%) Interstitium, infiltration cellular, lymphocyte 41 (46%) 55 (62%) 57 (63%) 40 (44%) Interstitium, inflammation, acute 1 (1%) Papilla, bacteria 1 (1%) Papilla, inflammation, acute 1 (1%) Pelvis, dilation 1 (1%) 2 (2%) Pelvis, inflammation, acute 1 (1%) Renal tubule, cyst 8 (9%) 11 (12%) 7 (8%) 10 (11%) Renal tubule, hyperplasia, focal 1 (1%) Renal tubule, mineral 1 (1%) 4 (4%) 4 (4%) 5 (6%) Urothelium, inflammation, chronic active 1 (1%) Ureter (0) (0) (1) (0) Inflammation, chronic active 1 (100%) Urinary bladder (87) (90) (90) (89) Hemorrhage 3 (3%) Infiltration cellular, lymphocyte 26 (30%) 33 (37%) 39 (43%) 41 (46%) C-18 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft D-1 Peer Review Draft NOT FOR ATTRIBUTION APPENDIX D SUMMARY OF LESIONS IN FEMALE MICE EXPOSED TO CDMA-MODULATED CELL PHONE RFR FOR 2 YEARS TABLE D1 Summary of the Incidence of Neoplasms in Female Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years.........................................................D-2 TABLE D2 Statistical Analysis of Primary Neoplasms in Female Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years.........................................................D-8 TABLE D3 Historical Incidence of Malignant Lymphoma in Control Female B6C3F1/N Mice..................D-11 TABLE D4 Summary of the Incidence of Nonneoplastic Lesions in Female Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years.......................................................D-12 D-2 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE D1 Summary of the Incidence of Neoplasms in Female Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Yearsa Sham Control 2.5 W/kg 5 W/kg 10 W/kg Disposition Summary Animals initially in study 105 104 105 105 14-Week interim evaluation 15 15 15 15 Early deaths Moribund 9 5 4 4 Natural deaths 14 9 16 14 Survivors Died last week of study 1 3 1 1 Terminal euthanasia 66 72 69 71 Animals examined microscopically 100 99 100 100 Systems Examined at 14 Weeks with No Neoplasms Observed Alimentary System Cardiovascular System Endocrine System General Body System Genital System Hematopoietic System Integumentary System Musculoskeletal System Nervous System Respiratory System Special Senses System Urinary System 2-Year Study Alimentary System Esophagus (87) (88) (87) (87) Gallbladder (79) (75) (72) (73) Intestine large, cecum (84) (82) (80) (81) Fibrosarcoma, metastatic, skin 1 (1%) Intestine large, colon (84) (85) (85) (86) Intestine large, rectum (88) (86) (84) (88) Fibrosarcoma, metastatic, skin 1 (1%) Osteosarcoma, metastatic, skin 1 (1%) Intestine small, duodenum (82) (81) (80) (77) Fibrosarcoma, metastatic, skin 1 (1%) Intestine small, ileum (83) (82) (76) (81) Intestine small, jejunum (84) (81) (80) (77) Liver (89) (88) (90) (90) Fibrosarcoma, metastatic, skin 1 (1%) Hemangiosarcoma 1 (1%) Hepatoblastoma 1 (1%) Hepatocellular adenoma 14 (16%) 20 (23%) 17 (19%) 13 (14%) Hepatocellular adenoma, multiple 5 (6%) 4 (5%) 5 (6%) 7 (8%) Hepatocellular carcinoma 6 (7%) 5 (6%) 3 (3%) 5 (6%) Hepatocellular carcinoma, multiple 2 (2%) 2 (2%) Hepatocholangiocarcinoma 1 (1%) Osteosarcoma, metastatic, bone 1 (1%) 1 (1%) Osteosarcoma, metastatic, brain 1 (1%) Osteosarcoma, metastatic, skin 1 (1%) Sarcoma, metastatic, skeletal muscle 1 (1%) GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 D-3 Peer Review Draft NOT FOR ATTRIBUTION TABLE D1 Summary of the Incidence of Neoplasms in Female Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Alimentary System (continued) Mesentery (29) (24) (34) (24) Fibrosarcoma, metastatic, skin 1 (3%) Leiomyosarcoma, metastatic, uterus 1 (4%) Renal mesenchymal tumor, metastatic, kidney 1 (3%) Sarcoma, metastatic, skeletal muscle 1 (4%) Fat, hemangioma 1 (3%) Fat, lipoma 2 (8%) 1 (3%) Pancreas (87) (86) (85) (84) Fibrosarcoma, metastatic, skin 1 (1%) Leiomyosarcoma, metastatic, uterus 1 (1%) Renal mesenchymal tumor, metastatic, kidney 1 (1%) Acinus, adenoma 1 (1%) Salivary glands (89) (88) (87) (89) Stomach, forestomach (86) (88) (87) (87) Fibrosarcoma, metastatic, skin 1 (1%) Leiomyosarcoma, metastatic, uterus 1 (1%) Squamous cell papilloma 1 (1%) 1 (1%) 1 (1%) Stomach, glandular (85) (88) (85) (83) Fibrosarcoma, metastatic, skin 1 (1%) Cardiovascular System Aorta (84) (87) (89) (90) Heart (90) (89) (90) (90) Osteosarcoma, metastatic, bone 1 (1%) 1 (1%) Osteosarcoma, metastatic, skin 1 (1%) Sarcoma, metastatic, skeletal muscle 1 (1%) Endocrine System Adrenal cortex (84) (88) (87) (88) Adenoma 1 (1%) Adrenal medulla (83) (87) (84) (84) Pheochromocytoma benign 1 (1%) Pheochromocytoma malignant 2 (2%) Bilateral, pheochromocytoma benign 1 (1%) Islets, pancreatic (87) (88) (89) (87) Adenoma 1 (1%) Carcinoma 1 (1%) Parathyroid gland (60) (59) (65) (68) Pituitary gland (80) (79) (88) (86) Pars distalis, adenoma 6 (8%) 8 (10%) 8 (9%) 1 (1%) Pars distalis, carcinoma 1 (1%) Pars distalis, fibrosarcoma, metastatic, skin 1 (1%) Thyroid gland (86) (87) (88) (88) C-cell carcinoma 1 (1%) Follicular cell, adenoma 2 (2%) 1 (1%) 1 (1%) General Body System Tissue NOS (1) (1) (1) (0) Hemangiosarcoma 1 (100%) Abdominal, osteosarcoma, metastatic, skin 1 (100%) D-4 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE D1 Summary of the Incidence of Neoplasms in Female Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Genital System Clitoral gland (82) (82) (81) (82) Ovary (75) (84) (84) (83) Adenocarcinoma, metastatic, uterus 2 (2%) Cystadenoma 2 (3%) 2 (2%) 6 (7%) 6 (7%) Granulosa cell tumor benign 1 (1%) Hemangioma 2 (3%) 1 (1%) Luteoma 2 (2%) 1 (1%) Teratoma benign 1 (1%) Thecoma malignant 1 (1%) Tubulostromal adenoma 1 (1%) Uterus (89) (89) (88) (90) Adenocarcinoma 2 (2%) 1 (1%) Adenoma 1 (1%) Fibroma 1 (1%) Fibrosarcoma, metastatic, skin 1 (1%) Granular cell tumor malignant 1 (1%) Hemangiosarcoma 1 (1%) 1 (1%) Leiomyoma 1 (1%) Leiomyosarcoma 1 (1%) 1 (1%) 2 (2%) Polyp stromal 1 (1%) Hematopoietic System Bone marrow (90) (89) (89) (89) Hemangiosarcoma 1 (1%) Lymph node (18) (21) (18) (18) Bronchial, adenocarcinoma, metastatic, uterus 1 (5%) Bronchial, alveolar/bronchiolar carcinoma, metastatic, lung 1 (6%) Bronchial, fibrosarcoma, metastatic, skin 1 (6%) Iliac, hemangiosarcoma 1 (5%) Lumbar, leiomyosarcoma, metastatic, uterus 1 (6%) Pancreatic, adenocarcinoma, metastatic, uterus 1 (5%) Lymph node, mandibular (76) (79) (76) (73) Lymph node, mesenteric (71) (86) (75) (81) Adenocarcinoma, metastatic, uterus 1 (1%) Fibrosarcoma, metastatic, skin 1 (1%) Hemangiosarcoma 1 (1%) Leiomyosarcoma, metastatic, uterus 1 (1%) Renal mesenchymal tumor, metastatic, kidney 1 (1%) Sarcoma, metastatic, skeletal muscle 1 (1%) Spleen (86) (87) (86) (88) Hemangiosarcoma 3 (3%) 2 (2%) 1 (1%) Leiomyosarcoma, metastatic, uterus 1 (1%) Thymus (85) (83) (82) (82) Osteosarcoma, metastatic, bone 1 (1%) GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 D-5 Peer Review Draft NOT FOR ATTRIBUTION TABLE D1 Summary of the Incidence of Neoplasms in Female Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Integumentary System Mammary gland (85) (87) (90) (88) Adenocarcinoma 2 (2%) Adenoma 1 (1%) 2 (2%) Skin (90) (89) (90) (90) Squamous cell carcinoma 1 (1%) Subcutaneous tissue, fibroma 1 (1%) Subcutaneous tissue, fibroma, multiple 1 (1%) Subcutaneous tissue, fibrosarcoma 3 (3%) 1 (1%) 3 (3%) 2 (2%) Subcutaneous tissue, fibrosarcoma, multiple 1 (1%) Subcutaneous tissue, hemangioma 1 (1%) Subcutaneous tissue, hemangiosarcoma 2 (2%) 1 (1%) Subcutaneous tissue, lipoma 1 (1%) Subcutaneous tissue, malignant fibrous histiocytoma 1 (1%) 1 (1%) Subcutaneous tissue, osteosarcoma 1 (1%) Subcutaneous tissue, sarcoma 2 (2%) Musculoskeletal System Bone (90) (89) (90) (89) Hemangioma 1 (1%) Osteosarcoma 1 (1%) 2 (2%) 1 (1%) 2 (2%) Skeletal muscle (89) (89) (90) (90) Adenocarcinoma, metastatic, uterus 1 (1%) Hemangiosarcoma 2 (2%) Leiomyosarcoma, metastatic, uterus 1 (1%) Osteosarcoma 1 (1%) Sarcoma 1 (1%) Nervous System Brain (87) (88) (90) (90) Carcinoma, metastatic, pituitary gland 1 (1%) Fibrosarcoma, metastatic, skin 1 (1%) Osteosarcoma, metastatic, skeletal muscle 1 (1%) Osteosarcoma, metastatic, uncertain primary site 1 (1%) Brain trigeminal ganglion (75) (82) (75) (74) Nerve trigeminal (56) (30) (52) (51) Peripheral nerve, sciatic (88) (88) (89) (88) Spinal cord (90) (89) (90) (90) Osteosarcoma, metastatic, bone 1 (1%) D-6 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE D1 Summary of the Incidence of Neoplasms in Female Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Respiratory System Lung (90) (89) (90) (90) Alveolar/bronchiolar adenoma 3 (3%) 6 (7%) 4 (4%) 1 (1%) Alveolar/bronchiolar adenoma, multiple 1 (1%) Alveolar/bronchiolar carcinoma 3 (3%) 3 (3%) 3 (3%) 5 (6%) Carcinoma, metastatic, thyroid gland 1 (1%) Fibrosarcoma, metastatic, skin 1 (1%) 1 (1%) Granular cell tumor malignant, metastatic, uterus 1 (1%) Hepatocellular carcinoma, metastatic, liver 2 (2%) 1 (1%) Osteosarcoma, metastatic, bone 1 (1%) 1 (1%) 1 (1%) 2 (2%) Osteosarcoma, metastatic, brain 1 (1%) Osteosarcoma, metastatic, skeletal muscle 1 (1%) Osteosarcoma, metastatic, skin 1 (1%) Sarcoma, metastatic, skeletal muscle 1 (1%) Squamous cell carcinoma, metastatic, skin 1 (1%) Mediastinum (2) (0) (0) (0) Hepatocellular carcinoma, metastatic, liver 1 (50%) Nose (89) (89) (90) (90) Respiratory epithelium, adenoma 1 (1%) Trachea (90) (87) (89) (88) Special Senses System Eye (89) (89) (90) (89) Harderian gland (89) (88) (89) (89) Adenocarcinoma 1 (1%) 1 (1%) 2 (2%) Adenoma 4 (4%) 8 (9%) 8 (9%) 4 (4%) Urinary System Kidney (89) (89) (88) (87) Adenocarcinoma, metastatic, uterus 1 (1%) Renal mesenchymal tumor 1 (1%) Renal tubule, adenoma 2 (2%) Urinary bladder (86) (86) (83) (85) Systemic Lesions Multiple organsb (90) (89) (90) (90) Histiocytic sarcoma 8 (9%) 3 (3%) 2 (2%) 7 (8%) Leukemia erythrocytic 1 (1%) Leukemia granulocytic 2 (2%) Lymphoma malignant 2 (2%) 9 (10%) 6 (7%) 7 (8%) GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 D-7 Peer Review Draft NOT FOR ATTRIBUTION TABLE D1 Summary of the Incidence of Neoplasms in Female Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Neoplasm Summary Total animals with primary neoplasmsc 2-Year study 59 62 56 56 Total primary neoplasms 2-Year study 85 96 88 83 Total animals with benign neoplasms 2-Year study 36 42 43 32 Total benign neoplasms 2-Year study 47 55 59 42 Total animals with malignant neoplasms 2-Year study 33 32 26 36 Total malignant neoplasms 2-Year study 38 41 29 41 Total animals with metastatic neoplasms 2-Year study 9 6 3 6 Total metastatic neoplasms 2-Year study 29 17 5 16 Total animals with malignant neoplasmsof uncertain primary site 2-Year study 1 a Number of animals examined microscopically at the site and the number of animals with neoplasm b Number of animals with any tissue examined microscopically c Primary neoplasms: all neoplasms except metastatic neoplasms D-8 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE D2 Statistical Analysis of Primary Neoplasms in Female Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg Harderian Gland: Adenoma Overall ratea 4/90 (4%) 8/89 (9%) 8/90 (9%) 4/90 (4%) Adjusted rateb 5.0% 9.5% 9.6% 4.8% Terminal ratec 4/67 (6%) 8/74 (11%) 7/69 (10%) 4/71 (6%) First incidence (days) 739 (T) 739 (T) 704 739 (T) Poly-3 testd P=0.415N P=0.208 P=0.208 P=0.621N Harderian Gland: Adenoma or Carcinoma Overall rate 4/90 (4%) 9/89 (10%) 9/90 (10%) 6/90 (7%) Adjusted rate 5.0% 10.7% 10.7% 7.2% Terminal rate 4/67 (6%) 9/74 (12%) 8/69 (12%) 5/71 (7%) First incidence (days) 739 (T) 739 (T) 704 653 Poly-3 test P=0.482 P=0.143 P=0.143 P=0.397 Liver: Hepatocellular Adenoma Overall rate 19/89 (21%)e 24/88 (27%) 22/90 (24%) 20/90 (22%) Adjusted rate 23.6% 28.8% 26.0% 24.1% Terminal rate 17/67 (25%) 22/73 (30%) 17/69 (25%) 18/71 (25%) First incidence (days) 511 579 644 679 Poly-3 test P=0.466N P=0.282 P=0.429 P=0.543 Liver: Hepatocellular Carcinoma Overall rate 8/89 (9%) 5/88 (6%) 5/90 (6%) 5/90 (6%) Adjusted rate 10.0% 6.0% 6.0% 6.0% Terminal rate 7/67 (10%) 3/73 (4%) 3/69 (4%) 5/71 (7%) First incidence (days) 656 639 692 739 (T) Poly-3 test P=0.255N P=0.255N P=0.251N P=0.259N Liver: Hepatocellular Adenoma or Carcinoma Overall rate 25/89 (28%) 29/88 (33%) 26/90 (29%) 22/90 (24%) Adjusted rate 30.9% 34.5% 30.6% 26.5% Terminal rate 22/67 (33%) 25/73 (34%) 19/69 (28%) 20/71 (28%) First incidence (days) 511 579 644 679 Poly-3 test P=0.217N P=0.371 P=0.552N P=0.325N Liver: Hepatocellular Carcinoma or Hepatoblastoma Overall rate 9/89 (10%) 5/88 (6%) 5/90 (6%) 5/90 (6%) Adjusted rate 11.3% 6.0% 6.0% 6.0% Terminal rate 8/67 (12%) 3/73 (4%) 3/69 (4%) 5/71 (7%) First incidence (days) 656 639 692 739 (T) Poly-3 test P=0.186N P=0.178N P=0.174N P=0.181N Lung: Alveolar/bronchiolar Adenoma Overall rate 3/90 (3%) 6/89 (7%) 4/90 (4%) 2/90 (2%) Adjusted rate 3.8% 7.2% 4.8% 2.4% Terminal rate 3/67 (5%) 5/74 (7%) 4/69 (6%) 2/71 (3%) First incidence (days) 739 (T) 738 739 (T) 739 (T) Poly-3 test P=0.262N P=0.271 P=0.525 P=0.484N Lung: Alveolar/bronchiolar Carcinoma Overall rate 3/90 (3%) 3/89 (3%) 3/90 (3%) 5/90 (6%) Adjusted rate 3.7% 3.6% 3.6% 6.0% Terminal rate 2/67 (3%) 3/74 (4%) 1/69 (1%) 4/71 (6%) First incidence (days) 607 739 (T) 511 684 Poly-3 test P=0.270 P=0.641N P=0.638N P=0.377 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 D-9 Peer Review Draft NOT FOR ATTRIBUTION TABLE D2 Statistical Analysis of Primary Neoplasms in Female Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg Lung: Alveolar/bronchiolar Adenoma or Carcinoma Overall rate 6/90 (7%) 9/89 (10%) 7/90 (8%) 6/90 (7%) Adjusted rate 7.5% 10.7% 8.3% 7.2% Terminal rate 5/67 (8%) 8/74 (11%) 5/69 (7%) 5/71 (7%) First incidence (days) 607 738 511 684 Poly-3 test P=0.423N P=0.325 P=0.536 P=0.595N Ovary: Cystadenoma Overall rate 2/75 (3%) 2/84 (2%) 6/84 (7%) 6/83 (7%) Adjusted rate 3.0% 2.5% 7.6% 7.9% Terminal rate 2/56 (4%) 2/70 (3%) 6/66 (9%) 5/65 (8%) First incidence (days) 739 (T) 739 (T) 739 (T) 597 Poly-3 test P=0.077 P=0.627N P=0.202 P=0.189 Pituitary Gland (Pars Distalis): Adenoma Overall rate 6/80 (8%) 8/79 (10%) 8/88 (9%) 1/86 (1%) Adjusted rate 8.4% 10.7% 9.8% 1.3% Terminal rate 5/60 (8%) 8/67 (12%) 6/68 (9%) 1/68 (2%) First incidence (days) 703 739 (T) 704 739 (T) Poly-3 test P=0.029N P=0.430 P=0.499 P=0.043N Pituitary Gland (Pars Distalis): Adenoma or Carcinoma Overall rate 6/80 (8%) 8/79 (10%) 8/88 (9%) 2/86 (2%) Adjusted rate 8.4% 10.7% 9.8% 2.5% Terminal rate 5/60 (8%) 8/67 (12%) 6/68 (9%) 2/68 (3%) First incidence (days) 703 739 (T) 704 739 (T) Poly-3 test P=0.063N P=0.430 P=0.499 P=0.104N Skin (Subcutaneous Tissue): Fibrosarcoma or Sarcoma Overall rate 5/90 (6%) 1/89 (1%) 3/90 (3%) 3/90 (3%) Adjusted rate 6.2% 1.2% 3.6% 3.6% Terminal rate 1/67 (2%) 0/74 (0%) 1/69 (1%) 2/71 (3%) First incidence (days) 607 715 669 731 Poly-3 test P=0.422N P=0.097N P=0.338N P=0.346N Skin (Subcutaneous Tissue): Fibroma, Fibrosarcoma, or Sarcoma Overall rate 6/90 (7%) 1/89 (1%) 3/90 (3%) 3/90 (3%) Adjusted rate 7.4% 1.2% 3.6% 3.6% Terminal rate 2/67 (3%) 0/74 (0%) 1/69 (1%) 2/71 (3%) First incidence (days) 607 715 669 731 Poly-3 test P=0.301N P=0.054N P=0.228N P=0.235N All Organs: Hemangiosarcoma Overall rate 2/90 (2%) 7/89 (8%) 2/90 (2%) 3/90 (3%) Adjusted rate 2.5% 8.3% 2.4% 3.6% Terminal rate 1/67 (2%) 4/74 (5%) 0/69 (0%) 2/71 (3%) First incidence (days) 703 626 644 653 Poly-3 test P=0.436N P=0.098 P=0.674N P=0.517 All Organs: Hemangioma or Hemangiosarcoma Overall rate 6/90 (7%) 8/89 (9%) 2/90 (2%) 4/90 (4%) Adjusted rate 7.5% 9.5% 2.4% 4.8% Terminal rate 5/67 (8%) 5/74 (7%) 0/69 (0%) 3/71 (4%) First incidence (days) 703 626 644 653 Poly-3 test P=0.161N P=0.431 P=0.122N P=0.349N D-10 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE D2 Statistical Analysis of Primary Neoplasms in Female Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg All Organs: Histiocytic Sarcoma Overall rate 8/90 (9%) 3/89 (3%) 2/90 (2%) 7/90 (8%) Adjusted rate 9.7% 3.5% 2.4% 8.4% Terminal rate 2/67 (3%) 1/74 (1%) 0/69 (0%) 5/71 (7%) First incidence (days) 562 493 725 675 Poly-3 test P=0.558 P=0.098N P=0.048N P=0.494N All Organs: Malignant Lymphoma Overall rate 2/90 (2%) 9/89 (10%) 6/90 (7%) 7/90 (8%) Adjusted rate 2.5% 10.7% 7.2% 8.4% Terminal rate 1/67 (2%) 8/74 (11%) 4/69 (6%) 4/71 (6%) First incidence (days) 604 689 716 635 Poly-3 test P=0.220 P=0.035 P=0.152 P=0.094 (T) Terminal euthanasia a Number of neoplasm-bearing animals/number of animals examined. Denominator is number of animals examined microscopically for liver, lung, ovary, and pituitary gland; for other tissues, denominator is number of animals necropsied. b Poly-3 estimated neoplasm incidence after adjustment for intercurrent mortality c Observed incidence at terminal euthanasia d Beneath the sham control incidence is the P value associated with the trend test. Beneath the exposed group incidence are the P values corresponding to pairwise comparisons between the sham controls and that exposed group. The Poly-3 test accounts for differential mortality in animals that do not reach terminal euthanasia. A negative trend or a lower incidence in an exposure group is indicated by N. e A single incidence of hepatoblastoma occurred in an animal that also had an adenoma. GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 D-11 Peer Review Draft NOT FOR ATTRIBUTION TABLE D3 Historical Incidence of Malignant Lymphoma in Control Female B6C3F1/N Micea Incidence in Controls Overall Historical Incidence: All Routes Total (%) 89/590 (15.1%) Mean ± standard deviation 16.0% ± 8.3% Range 2%-36% a Data as of August 2017; includes data for histiocytic, lymphocytic, mixed, unspecified, or undifferentiated cell types D-12 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE D4 Summary of the Incidence of Nonneoplastic Lesions in Female Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Yearsa Sham Control 2.5 W/kg 5 W/kg 10 W/kg Disposition Summary Animals initially in study 105 104 105 105 14-Week interim evaluation 15 15 15 15 Early deaths Moribund 9 5 4 4 Natural deaths 14 9 16 14 Survivors Died last week of study 1 3 1 1 Terminal euthanasia 66 72 69 71 Animals examined microscopically 100 99 100 100 14-Week Interim Evaluation Alimentary System Liver (10) (10) (10) (10) Inflammation, focal 1 (10%) 3 (30%) 2 (20%) Necrosis, focal 1 (10%) Endocrine System Thyroid gland (10) (10) (10) (10) Infiltration cellular, lymphocyte 1 (10%) Hematopoietic System Lymph node, mandibular (8) (8) (9) (10) Hemorrhage 1 (11%) Thymus (10) (10) (10) (10) Hemorrhage 1 (10%) 2 (20%) Nervous System Spinal cord (10) (10) (10) (10) Cyst, squamous 1 (10%) Respiratory System Lung (10) (10) (10) (10) Hemorrhage 1 (10%) Special Senses System Eye (10) (10) (10) (10) Retina, dysplasia 1 (10%) Urinary System Kidney (10) (10) (10) (10) Nephropathy, chronic progressive 1 (10%) Interstitium, infiltration cellular, lymphocyte 1 (10%) 1 (10%) 5 (50%) Urinary bladder (10) (10) (10) (10) Infiltration cellular, lymphocyte 1 (10%) 2 (20%) a Number of animals examined microscopically at the site and the number of animals with lesion GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 D-13 Peer Review Draft NOT FOR ATTRIBUTION TABLE D4 Summary of the Incidence of Nonneoplastic Lesions in Female Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 14-Week Interim Evaluation (continued) Systems Examined with No Lesions Observed Cardiovascular System General Body System Genital System Integumentary System Musculoskeletal System 2-Year Study Alimentary System Esophagus (87) (88) (87) (87) Gallbladder (79) (75) (72) (73) Cyst 1 (1%) Infiltration cellular, lymphocyte 2 (3%) 4 (5%) 2 (3%) 3 (4%) Epithelium, hyperplasia, diffuse 1 (1%) Intestine large, cecum (84) (82) (80) (81) Intestine large, colon (84) (85) (85) (86) Intestine large, rectum (88) (86) (84) (88) Intestine small, duodenum (82) (81) (80) (77) Inflammation, acute 1 (1%) Intestine small, ileum (83) (82) (76) (81) Inflammation, suppurative 1 (1%) Peyer’s patch, hyperplasia, lymphoid 2 (2%) Intestine small, jejunum (84) (81) (80) (77) Peyer’s patch, hyperplasia, lymphoid 1 (1%) 2 (2%) Liver (89) (88) (90) (90) Angiectasis 1 (1%) Basophilic focus 4 (4%) 4 (5%) 3 (3%) 1 (1%) Clear cell focus 1 (1%) Eosinophilic focus 2 (2%) 2 (2%) 2 (2%) Extramedullary hematopoiesis 1 (1%) 2 (2%) 2 (2%) Fatty change 7 (8%) 1 (1%) 2 (2%) 9 (10%) Hemorrhage 1 (1%) 1 (1%) 1 (1%) Infiltration cellular, lymphocyte 33 (37%) 22 (25%) 26 (29%) 24 (27%) Infiltration cellular, mononuclear cell 1 (1%) Inflammation, focal 4 (4%) 2 (2%) Inflammation, chronic active 1 (1%) 2 (2%) Mixed cell focus 5 (6%) Necrosis 6 (7%) 2 (2%) 3 (3%) 4 (4%) Centrilobular, necrosis 1 (1%) Hepatocyte, fatty change, focal 3 (3%) 1 (1%) Hepatocyte, hypertrophy 1 (1%) Kupffer cell, hyperplasia 1 (1%) Oval cell, hyperplasia 1 (1%) Mesentery (29) (24) (34) (24) Artery, inflammation, chronic 1 (3%) Fat, infiltration cellular, lymphocyte 2 (7%) 1 (3%) 1 (4%) Fat, inflammation, chronic 2 (8%) Fat, inflammation, chronic active 1 (3%) 2 (8%) Fat, mineral 1 (4%) 2 (6%) Fat, necrosis 25 (86%) 22 (92%) 30 (88%) 19 (79%) D-14 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE D4 Summary of the Incidence of Nonneoplastic Lesions in Female Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Alimentary System (continued) Pancreas (87) (86) (85) (84) Infiltration cellular, lymphocyte 27 (31%) 23 (27%) 21 (25%) 19 (23%) Inflammation, chronic active 1 (1%) Necrosis 1 (1%) 2 (2%) Acinus, atrophy 1 (1%) 2 (2%) Duct, cyst 1 (1%) 3 (4%) 1 (1%) Salivary glands (89) (88) (87) (89) Atrophy 1 (1%) Infiltration cellular, lymphocyte 59 (66%) 61 (69%) 54 (62%) 60 (67%) Stomach, forestomach (86) (88) (87) (87) Cyst 1 (1%) Epithelium, hyperplasia, focal 1 (1%) 1 (1%) Stomach, glandular (85) (88) (85) (83) Cyst 3 (4%) 2 (2%) Infiltration cellular, lymphocyte 2 (2%) Cardiovascular System Aorta (84) (87) (89) (90) Degeneration 1 (1%) Inflammation, acute 1 (1%) Inflammation, chronic active 1 (1%) Thrombus 1 (1%) Heart (90) (89) (90) (90) Bacteria 1 (1%) 1 (1%) 2 (2%) Cardiomyopathy 3 (3%) 4 (4%) 4 (4%) 6 (7%) Thrombus 3 (3%) 2 (2%) Artery, inflammation, chronic active 2 (2%) 1 (1%) Endothelium, hyperplasia 1 (1%) Epicardium, infiltration cellular, mixed cell 1 (1%) Epicardium, infiltration cellular, mononuclear cell 1 (1%) Myocardium, fibrosis 1 (1%) 1 (1%) Myocardium, hemorrhage 1 (1%) Myocardium, inflammation, acute 2 (2%) Myocardium, inflammation, chronic active 1 (1%) 1 (1%) 2 (2%) Myocardium, mineral 4 (4%) 1 (1%) 2 (2%) Myocardium, necrosis 1 (1%) Valve, hemorrhage 1 (1%) Valve, infiltration cellular, lymphocyte 1 (1%) Valve, thrombus 1 (1%) 1 (1%) Endocrine System Adrenal cortex (84) (88) (87) (88) Accessory adrenal cortical nodule 2 (2%) 3 (3%) Angiectasis 1 (1%) Hemorrhage 1 (1%) 1 (1%) 1 (1%) Hyperplasia, focal 1 (1%) Infiltration cellular, mixed cell 1 (1%) Mineral 1 (1%) Vacuolization cytoplasmic 1 (1%) Vacuolization cytoplasmic, focal 1 (1%) GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 D-15 Peer Review Draft NOT FOR ATTRIBUTION TABLE D4 Summary of the Incidence of Nonneoplastic Lesions in Female Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Endocrine System (continued) Adrenal cortex (continued) (84) (88) (87) (88) Bilateral, extramedullary hematopoiesis 1 (1%) Bilateral, infiltration cellular, mixed cell 1 (1%) Bilateral, vacuolization cytoplasmic 1 (1%) 2 (2%) Subcapsular, hyperplasia 81 (96%) 84 (95%) 84 (97%) 86 (98%) Adrenal medulla (83) (87) (84) (84) Hemorrhage 2 (2%) Hyperplasia 2 (2%) 1 (1%) Mineral 1 (1%) Islets, pancreatic (87) (88) (89) (87) Hyperplasia 1 (1%) 1 (1%) 2 (2%) Infiltration cellular, lymphocyte 3 (3%) 3 (3%) 5 (6%) 1 (1%) Parathyroid gland (60) (59) (65) (68) Cyst 1 (2%) Infiltration cellular, lymphocyte 1 (2%) 1 (1%) Pituitary gland (80) (79) (88) (86) Pars distalis, angiectasis 2 (3%) 9 (11%) 4 (5%) 2 (2%) Pars distalis, cyst 1 (1%) 1 (1%) 1 (1%) 2 (2%) Pars distalis, hyperplasia, focal 2 (3%) 2 (3%) 4 (5%) 6 (7%) Thyroid gland (86) (87) (88) (88) Infiltration cellular, lymphocyte 1 (1%) 1 (1%) 7 (8%) 5 (6%) Inflammation, chronic active 1 (1%) Follicle, cyst 1 (1%) 2 (2%) 3 (3%) General Body System Tissue NOS (1) (1) (1) (0) Genital System Clitoral gland (82) (82) (81) (82) Infiltration cellular, lymphocyte 3 (4%) 1 (1%) Inflammation, granulomatous 1 (1%) Duct, cyst 1 (1%) 1 (1%) Ovary (75) (84) (84) (83) Angiectasis 3 (4%) Cyst 9 (12%) 11 (13%) 7 (8%) 4 (5%) Hemorrhage 1 (1%) 1 (1%) Infiltration cellular, histiocyte 1 (1%) Inflammation, granulomatous 1 (1%) Mineral 1 (1%) 1 (1%) Follicle, cyst 9 (12%) 7 (8%) 6 (7%) 8 (10%) Granulosa cell, hyperplasia 1 (1%) Paraovarian tissue, cyst 2 (2%) Uterus (89) (89) (88) (90) Adenomyosis 1 (1%) Angiectasis 1 (1%) 3 (3%) 3 (3%) 4 (4%) Dilation 35 (39%) 21 (24%) 44 (50%) 37 (41%) Hemorrhage 1 (1%) Infiltration cellular, lymphocyte 1 (1%) Inflammation, chronic active 1 (1%) Mineral 1 (1%) Necrosis 1 (1%) Thrombus 1 (1%) 3 (3%) 1 (1%) D-16 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE D4 Summary of the Incidence of Nonneoplastic Lesions in Female Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Genital System (continued) Uterus (continued) (89) (89) (88) (90) Arteriole, degeneration 1 (1%) Endometrium, cyst 3 (3%) 2 (2%) Endometrium, hyperplasia, cystic 68 (76%) 75 (84%) 67 (76%) 68 (76%) Endometrium, metaplasia, squamous 1 (1%) Hematopoietic System Bone marrow (90) (89) (89) (89) Hypercellularity 7 (8%) 8 (9%) 3 (3%) 4 (4%) Hypocellularity 1 (1%) 1 (1%) Myeloid cell, hypercellularity 1 (1%) 1 (1%) Lymph node (18) (21) (18) (18) Hemorrhage 1 (6%) Hyperplasia, lymphoid 1 (6%) Infiltration cellular, mixed cell 1 (6%) Axillary, infiltration cellular, mixed cell 1 (6%) Axillary, pigment 1 (6%) Bronchial, hemorrhage 1 (6%) Bronchial, hyperplasia, lymphoid 2 (11%) 2 (10%) 1 (6%) Bronchial, infiltration cellular, histiocyte 1 (5%) Bronchial, infiltration cellular, mixed cell 1 (5%) Iliac, hemorrhage 1 (6%) 3 (17%) 1 (6%) Iliac, hyperplasia, lymphoid 4 (22%) 4 (19%) 9 (50%) 4 (22%) Iliac, infiltration cellular, histiocyte 1 (5%) 1 (6%) Iliac, infiltration cellular, mixed cell 1 (6%) 1 (5%) 1 (6%) 1 (6%) Iliac, infiltration cellular, plasma cell 1 (6%) Iliac, pigment 1 (5%) 2 (11%) Lumbar, hemorrhage 1 (5%) Lumbar, hyperplasia, lymphoid 2 (10%) 1 (6%) Lumbar, infiltration cellular, mixed cell 1 (6%) Mediastinal, hyperplasia, lymphoid 1 (6%) 4 (19%) 1 (6%) 3 (17%) Mediastinal, infiltration cellular, histiocyte 1 (6%) Pancreatic, hyperplasia, lymphoid 1 (6%) 1 (6%) Renal, ectasia 1 (5%) Renal, hemorrhage 1 (6%) Renal, hyperplasia, lymphoid 3 (17%) 2 (11%) 2 (11%) Renal, infiltration cellular, mixed cell 1 (5%) Lymph node, mandibular (76) (79) (76) (73) Hemorrhage 3 (4%) 1 (1%) 1 (1%) 2 (3%) Hyperplasia, lymphoid 1 (1%) 1 (1%) 1 (1%) 2 (3%) Infiltration cellular, histiocyte 1 (1%) 1 (1%) Infiltration cellular, mixed cell 1 (1%) Lymph node, mesenteric (71) (86) (75) (81) Ectasia 1 (1%) Erythrophagocytosis 1 (1%) Hemorrhage 1 (1%) 3 (3%) 6 (8%) 3 (4%) Hyperplasia, lymphoid 1 (1%) 5 (6%) 4 (5%) 4 (5%) Infiltration cellular, histiocyte 3 (4%) 4 (5%) 2 (3%) 4 (5%) Infiltration cellular, plasma cell 1 (1%) Spleen (86) (87) (86) (88) Atrophy 1 (1%) Extramedullary hematopoiesis 20 (23%) 18 (21%) 12 (14%) 16 (18%) Hemorrhage 1 (1%) Hyperplasia, lymphoid 11 (13%) 10 (11%) 12 (14%) 14 (16%) Capsule, fibrosis 1 (1%) 1 (1%) GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 D-17 Peer Review Draft NOT FOR ATTRIBUTION TABLE D4 Summary of the Incidence of Nonneoplastic Lesions in Female Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Hematopoietic System (continued) Thymus (85) (83) (82) (82) Atrophy 5 (6%) 3 (4%) 4 (5%) 2 (2%) Cyst 2 (2%) 4 (5%) 4 (5%) 6 (7%) Hemorrhage 2 (2%) 1 (1%) 2 (2%) Hyperplasia, lymphoid 1 (1%) 2 (2%) Integumentary System Mammary gland (85) (87) (90) (88) Hyperplasia, focal 1 (1%) 1 (1%) Hyperplasia, diffuse 1 (1%) 1 (1%) Infiltration cellular, lymphocyte 1 (1%) Duct, dilation 1 (1%) 2 (2%) 2 (2%) 2 (2%) Skin (90) (89) (90) (90) Ulcer 2 (2%) 3 (3%) 1 (1%) 1 (1%) Epidermis, hyperplasia, focal 1 (1%) 1 (1%) Hair follicle, atrophy 2 (2%) 2 (2%) 5 (6%) Subcutaneous tissue, fibrosis 1 (1%) Musculoskeletal System Bone (90) (89) (90) (89) Fibro-osseous lesion 11 (12%) 1 (1%) 2 (2%) Increased bone 1 (1%) 1 (1%) Skeletal muscle (89) (89) (90) (90) Degeneration 1 (1%) 1 (1%) Infiltration cellular, lymphocyte 16 (18%) 7 (8%) 11 (12%) 9 (10%) Mineral 1 (1%) Nervous System Brain (87) (88) (90) (90) Hemorrhage 2 (2%) 2 (2%) Hydrocephalus 1 (1%) Inflammation, acute 1 (1%) Mineral 80 (92%) 81 (92%) 78 (87%) 74 (82%) Necrosis 1 (1%) 1 (1%) Artery, meninges, inflammation, chronic active 3 (3%) 1 (1%) 1 (1%) Brain trigeminal ganglion (75) (82) (75) (74) Nerve trigeminal (56) (30) (52) (51) Peripheral nerve, sciatic (88) (88) (89) (88) Axon, degeneration 12 (14%) 4 (5%) 8 (9%) 11 (13%) Spinal cord (90) (89) (90) (90) Cyst, squamous, multiple 1 (1%) 1 (1%) Degeneration 1 (1%) Demyelination 1 (1%) Metaplasia, osseous 1 (1%) Necrosis 2 (2%) D-18 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE D4 Summary of the Incidence of Nonneoplastic Lesions in Female Mice Exposed to CDMA-Modulated Cell Phone RFR for 2 Years Sham Control 2.5 W/kg 5 W/kg 10 W/kg 2-Year Study (continued) Respiratory System Lung (90) (89) (90) (90) Congestion 2 (2%) 4 (4%) Hemorrhage 4 (4%) 7 (8%) 4 (4%) 4 (4%) Infiltration cellular, histiocyte 1 (1%) 2 (2%) 1 (1%) 2 (2%) Infiltration cellular, lymphocyte 3 (3%) 2 (2%) 4 (4%) Infiltration cellular, mixed cell 1 (1%) Infiltration cellular, mononuclear cell 1 (1%) Inflammation, granulomatous 1 (1%) Inflammation, acute 1 (1%) Inflammation, chronic 1 (1%) Inflammation, chronic active 1 (1%) Alveolar epithelium, hyperplasia, focal 1 (1%) 3 (3%) 3 (3%) 3 (3%) Mediastinum (2) (0) (0) (0) Nose (89) (89) (90) (90) Inflammation, acute 1 (1%) Respiratory epithelium, accumulation, hyaline droplet 1 (1%) Trachea (90) (87) (89) (88) Special Senses System Eye (89) (89) (90) (89) Phthisis bulbi 1 (1%) Anterior chamber, inflammation, acute 1 (1%) Harderian gland (89) (88) (89) (89) Hyperplasia, focal 1 (1%) Infiltration cellular, lymphocyte 58 (65%) 66 (75%) 61 (69%) 64 (72%) Urinary System Kidney (89) (89) (88) (87) Cyst 1 (1%) Infarct 14 (16%) 26 (29%) 23 (26%) 17 (20%) Metaplasia, osseous 2 (2%) 1 (1%) 2 (2%) 2 (2%) Nephropathy, chronic progressive 8 (9%) 12 (13%) 7 (8%) 7 (8%) Bilateral, infarct 1 (1%) Interstitium, infiltration cellular, lymphocyte 63 (71%) 65 (73%) 50 (57%) 50 (57%) Medulla, mineral 1 (1%) Papilla, mineral 2 (2%) Papilla, necrosis 1 (1%) Pelvis, dilation 1 (1%) Renal tubule, cyst 1 (1%) Renal tubule, dilation 1 (1%) 1 (1%) 1 (1%) Renal tubule, mineral 1 (1%) Renal tubule, vacuolization cytoplasmic 1 (1%) Urinary bladder (86) (86) (83) (85) Angiectasis 6 (7%) 2 (2%) Infiltration cellular, lymphocyte 62 (72%) 64 (74%) 70 (84%) 65 (76%) Transitional epithelium, hyperplasia, diffuse 1 (1%) E-1 Peer Review Draft NOT FOR ATTRIBUTION APPENDIX E GENETIC TOXICOLOGY COLLECTION OF TISSUE SAMPLES FOR GENOTOXICITY TESTING .........................................................................E-2 COMET ASSAY...........................................................................................................................................................E-2 MICRONUCLEUS ASSAY............................................................................................................................................E-3 DATA ANALYSIS FOR THE COMET AND MICRONUCLEUS ASSAYS ..........................................................................E-4 RESULTS....................................................................................................................................................................E-4 TABLE E1 DNA Damage in Male Mice Exposed to CDMA-Modulated Cell Phone RFR for 14 Weeks (100-Cell Method) .....................................E-5 TABLE E2 DNA Damage in Male Mice Exposed to GSM-Modulated Cell Phone RFR for 14 Weeks (100-Cell Method).........................................E-6 TABLE E3 DNA Damage in the Frontal Cortex of Male Mice Exposed to CDMA- or GSM-Modulated Cell Phone RFR for 14 Weeks (150-Cell Method).....................E-7 TABLE E4 DNA Damage in Female Mice Exposed to CDMA-Modulated Cell Phone RFR for 14 Weeks (100-Cell Method) .....................................E-8 TABLE E5 DNA Damage in Female Mice Exposed to GSM-Modulated Cell Phone RFR for 14 Weeks (100-Cell Method).........................................E-9 TABLE E6 DNA Damage in Female Mice Exposed to CDMA- or GSM-Modulated Cell Phone RFR for 14 Weeks (150-Cell Method)...................E-10 TABLE E7 Frequency of Micronuclei in Peripheral Blood Erythrocytes of Mice Following Exposure to CDMA- or GSM-Modulated Cell Phone RFR for 14 Weeks.....................................................................................................................................E-11 E-2 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft GENETIC TOXICOLOGY COLLECTION OF TISSUE SAMPLES FOR GENOTOXICITY TESTING Exposures ceased at 7 a.m. on the day of necropsy at 14 weeks. Thirty-five male mice (five sham controls, 15 that were exposed to CDMA, and 15 that were exposed to GSM) were necropsied approximately 2 to 4 hours after cessation of exposure and 35 female mice (five sham controls, 15 that were exposed to CDMA, and 15 that were exposed to GSM) were necropsied approximately 5 to 7 hours after cessation of exposure. Animals were necropsied in the following order: one animal from each exposure group starting with the sham control group, moving through each of the exposed groups for each of the radio frequency modulations in turn, then rotating back to the sham control group; animals were necropsied in numerical order within each exposure group. Five different tissues (cerebrum, frontal cortex, hippocampus, liver, and blood leukocytes) were collected from each animal for the comet assay. Because blood was examined in both the micronucleus and the comet assays, a single tube of blood was collected per animal by retroorbital bleeding, and the sample was divided into two aliquots, one that was processed for the comet assay and the other for the micronucleus assay. COMET ASSAY For preparation of samples for the comet assay, a 50 µL sample of blood was transferred to a tube containing 1 mL of freshly prepared cold mincing buffer [Mg+2, Ca+2, and phenol free Hank’s Balanced Salt Solution (Life Technologies, Carlsbad, CA) with 20 mM ethylenediaminetetraacetic acid (EDTA) pH 7.3 to 7.5 and 10% v/v fresh dimethyl sulfoxide (DMSO)]. The liver and the hippocampus, cerebellum, and frontal cortex sections of the brain were rinsed with cold mincing buffer to remove residual blood and held on ice briefly (≤5 minutes) until processed. Small portions (3 to 4 mm) of the left lobe of the liver and each brain section were placed in tubes containing cold mincing solution and rapidly minced until finely dispersed. All samples prepared for the comet assay were immediately flash frozen in liquid nitrogen (Recio et al., 2010) and subsequently transferred to a –80° C freezer for storage until shipment by overnight courier on dry ice to the analytical laboratory. Upon receipt, all samples were immediately placed in a –80° C freezer for storage until further processing. Blood and tissue samples were thawed on ice and maintained on ice during slide preparation. Just prior to use, each cell suspension was shaken gently to mix the cells and placed back on ice for 15 to 30 seconds to allow clumps to settle. A portion of the supernatant was empirically diluted with 0.5% low melting point agarose (Lonza, Walkersville, MD) dissolved in Dulbecco’s phosphate buffer (Ca+2, Mg+2, and phenol free) at 37° C and layered onto each well of a 2-well CometSlide™ (Trevigen, Gaithersburg, MD). Slides were immersed in cold lysing solution [2.5 M NaCl, 100 mM Na2EDTA, 10 mM tris(hydroxymethyl)aminomethane (Tris), pH 10, containing freshly added 10% DMSO (Fisher Scientific, Pittsburgh, PA) and 1% Triton X-100] overnight in a refrigerator, protected from light. The following day, the slides were rinsed in 0.4 M Trizma base (pH 7.5), randomly placed onto the platform of a horizontal electrophoresis unit and treated with cold alkali solution (300 mM NaOH, 1 mM Na2EDTA, pH>13) for 20 minutes to allow DNA unwinding, then electrophoresed at 4º to 9º C for 20 minutes at 25 V (0.7 V/cm), with a current of approximately 300 mA. Following electrophoresis, slides were neutralized with 0.4 M Trizma base (pH 7.5) for 5 minutes and then dehydrated by immersion in absolute ethanol (Pharmco-AAPER, Shelbyville, KY) for at least 5 minutes and allowed to air dry. Slides were prepared in a laboratory with a relative humidity no more than 60% and stored at room temperature in a desiccator with a relative humidity of no more than 60% until stained and scored; stained slides were stored in a desiccator. NaCl, Na2EDTA, Triton X-100, and Trizma base were purchased from Sigma-Aldrich (St. Louis, MO); NaOH was purchased from Fisher Scientific (Pittsburgh, PA). After staining with SYBR® Gold (Molecular Probes, Life Technologies, Grand Island, NY), slides, independently coded to mask treatment, were scored using Comet Assay IV Imaging Software, Version 4.3.1 (Perceptive Instruments, Ltd., Suffolk, UK) validated for GLP Part 11 compliance. In the alkaline (pH>13) comet assay, when damaged nuclear DNA fragments, it undergoes unidirectional migration through the agarose gel within an electrical field, forming an image that resembles a comet, and the greater the amount of fragmentation, the greater the amount of DNA migration that will occur. The image analysis software partitions the intensity of the fluorescent signal of the DNA in the entire comet image into the percent that is attributable to the comet head and the percent attributable GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 E-3 Peer Review Draft NOT FOR ATTRIBUTION to the tail. Manual adjustment of the automated detection of head and tail features is sometimes required. To evaluate DNA damage levels, the extent of DNA migration was characterized for 100 scorable comet figures per animal/tissue as percent tail DNA (intensity of all tail pixels divided by the total intensity of all pixels in the comet, expressed as a percentage). Comet figures are classified during the scoring process as scorable (evaluated for percent tail DNA), non-scorable (due to inability to evaluate percent tail DNA, e.g. if comets overlapped), and “hedgehog.” Hedgehogs either have no defined head, i.e., all DNA appears to be in the tail, or the head and tail appear to be separated. Hedgehogs may represent cells that have sustained high levels of DNA damage and are apoptotic, although certain data suggest they may represent cells with high levels of repairable DNA damage (Rundell et al., 2003; Lorenzo et al., 2013). The frequency of hedgehogs (%HH) was determined by tabulating the number observed in a separate group of 100 cells per animal/tissue. In Technical Report 595 (NTP, 2018), in which the comet assay results in rats exposed to cell phone radio frequency radiation (RFR) are reported, it was noted that a marked interanimal variation in percent tail DNA and high %HH values were observed in some tissues, yet the range of percent tail DNA values appeared to be truncated at approximately 65%. To better understand these observations, rat slides were reanalyzed by scoring 150 cells/tissue per animal, as recommended by the OECD guideline (OECD, 2014). In this rescoring of the rat samples, all scorable cells were included in the sample of 150 analyzed cells, regardless of the apparent level of DNA damage estimated by the scorer prior to software analysis of the images; highly damaged cells that were unscorable using the software (true HH) were not included. For the 150-cell scoring method, the %HH was not independently determined due to limitations at the time in the comet assay software arising from the added number of cells scored. Therefore, %HH was estimated by dividing the number of comets having more than 90% tail DNA by 150. Although far less interanimal variation was observed in mouse tissues compared to rat tissues, in an effort to maintain consistency in analyses across species, the mouse tissues that showed a clear response or a suggestion of a treatment-related effect were reevaluated using the same 150-cell approach that was used to reevaluate all of the rat tissues. These tissues included male mouse frontal cortex and female mouse liver and peripheral blood exposed to the CDMA and GSM modulations. Although there was no concurrent positive control group in these cell phone RFR studies, slides were made with human TK6 cells treated with ethyl methanesulfonate (standard positive control compound for the comet assay) and were included in each electrophoresis run with each slide set as an internal technical positive control. MICRONUCLEUS ASSAY For the micronucleus assay, sampling schedules were as described for the comet assay. At 14 weeks, blood samples (approximately 200 μL) obtained by retroorbital bleeding (one sample per mouse) were placed into EDTA tubes and immediately refrigerated. The samples were sent on the day of collection to the analytical laboratory well insulated on cold packs via overnight delivery. Upon arrival, blood samples were diluted in anticoagulant (heparin) and fixed in ice cold methanol (Sigma-Aldrich; St. Louis, MO) according to instructions provided with the MicroFlowPLUS Kit (Litron Laboratories, Rochester, NY). Fixed blood samples were stored in a –80° C freezer for at least 3 days prior to analysis by flow cytometry. Flow cytometric analysis of red blood cell samples was performed using MicroFlowPLUS Kit reagents and a FACSCalibur™ dual-laser bench top system (Becton Dickinson Biosciences, San Jose, CA) as described by Witt et al. (2008). Both mature [normochromatic erythrocytes (NCEs)] and immature [reticulocytes; polychromatic erythrocytes (PCEs)] erythrocytes were analyzed for the presence of micronuclei. Immature erythrocytes are distinguished by the presence of an active transferrin receptor (CD-71) on the cell surface. For each sample, 20,000 (± 2,000) immature CD71-positive erythrocytes were analyzed by flow cytometry to determine the frequency of micronucleated reticulocytes. Aggregates were excluded on the basis of forward and side scatter, platelets were excluded based on staining with an anti-CD61 antibody, and nucleated leukocytes were excluded on the basis of intense propidium iodide staining. Typically, more than one million NCEs (CD-71 negative) were enumerated concurrently during PCE analysis, allowing for calculation of the percentage of PCEs among total erythrocytes as a measure of bone marrow toxicity. E-4 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft DATA ANALYSIS FOR THE COMET AND MICRONUCLEUS ASSAYS Data from both the comet and the micronucleus assays were analyzed using the same statistical methods (Kissling et al., 2007). Mean percent tail DNA was calculated for each cell type for each animal; likewise, mean micronucleated PCEs/1,000 PCEs and micronucleated NCEs/1,000 NCEs, as well as % PCEs, were calculated for each animal. These data are summarized in the tables as mean ± standard error of the mean. Levene’s test was used to determine if variances among treatment groups were equal at P=0.05. When variances were equal, linear regression analysis was used to test for linear trend and Williams’ test was used to evaluate pairwise differences of each exposed group with the sham control group. When variances were unequal, nonparametric methods were used to analyze the data; Jonckheere’s test was used to evaluate linear trend and Dunn’s test was used to assess the significance of pairwise differences of each exposed group with the sham control group. To maintain the overall significance level at 0.05, the trend as well as the pairwise differences from the sham control group were declared statistically significant if P<0.025. A result was considered positive if the trend test was significant and if at least one exposed group was significantly elevated over the sham control group, or if two or more exposed groups were significantly increased over the corresponding sham control group. A response was considered equivocal if only the trend test was significant or if only a single exposed group was significantly increased over the sham control. RESULTS Twenty sets of tissues obtained from animals at the 14-week interim evaluation in the 2-year study were evaluated for DNA damage using the comet assay (two sexes, five tissues, two cell phone RFR modulations). Results are reported based on the 100-cell scoring approach that was the standard method in use at the time of the study. Data for some tissues obtained using a second, 150-cell scoring approach recommended by a recently adopted international guideline for the in vivo comet assay, are noted for comparison. Significant increases in DNA damage were observed in cells of the frontal cortex of male mice exposed to both modulations, CDMA and GSM (Tables E1 and E2). Positive results were also obtained for male mouse frontal cortex (CDMA and GSM) (Table E3) using the 150-cell approach. Of note is the low percent tail DNA value in the frontal cortex of sham control mice. There is no appropriate historical control database to provide context for this response, but bonafide changes in DNA damage levels in a treatment group should remain constant relative to the control value. No technical aspects of the study that may have influenced this control value independently of the treated group values (e.g., % agarose gel, duration of electrophoresis, electromagnetic field strength, slide position in the electrophoresis tank) were identified. Technical factors that influence control levels have not been shown to alter sensitivity to detect effects in treated groups (Recio et al., 2012). No other tissues showed evidence of a treatment-related effect in male mice. In female mice exposed to the CDMA modulation, significant increases in DNA damage were seen in blood leukocytes using both scoring approaches (Tables E4 and E6). In female mouse liver samples exposed to either modulation, the mean percent tail DNA was elevated above the sham control for all exposures when evaluated using either scoring approach. Results of the 100-cell scoring approach were judged to be negative (Tables E4 and E6); scoring 150 cells resulted in a negative call for GSM-exposed female mice (Table E5) but in CDMA-exposed female mouse liver, a significant increase (P=0.010) in percent tail DNA was seen in the 5 W/kg group, resulting in an equivocal call for this dataset (Table E6). In the micronucleus assay for male mice exposed to CDMA (Table E7), although a significant trend was observed for micronucleated PCEs (P=0.013), the absolute increase was quite small and fell within the laboratory’s historical control range. In addition, no corresponding increase in micronucleated NCEs was observed; the mature erythrocyte population ought to be in steady state equilibrium after continuous 14 weeks of exposure, such as occurred in this study. Thus, the overall result in the micronucleus assay for male mice exposed to CDMA was judged to be negative. No other significant effects on either micronucleus frequency or % PCEs were seen in male or female mice exposed to either modulation of cell phone RFR. GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 E-5 Peer Review Draft NOT FOR ATTRIBUTION TABLE E1 DNA Damage in Male Mice Exposed to CDMA-Modulated Cell Phone RFR for 14 Weeks (100-Cell Method)a Dose (W/kg) Percent Tail DNAb P Valuec Percent Hedgehogsb Frontal Cortex Sham Controld 0 0.63 ± 0.08 0.40 ± 0.24 CDMA 2.5 3.46 ± 0.65 0.014 0.60 ± 0.40 5 5.88 ± 1.06 0.001 0.60 ± 0.24 10 8.85 ± 1.09 0.001 4.40 ± 1.69 P=0.001e Hippocampus Sham Control 0 7.69 ± 2.00 1.20 ± 0.58 CDMA 2.5 9.59 ± 4.33 0.521 5.40 ± 2.11 5 6.44 ± 1.21 0.606 2.80 ± 0.97 10 6.38 ± 0.93 0.641 4.40 ± 2.27 P=0.740 Cerebellum Sham Control 0 5.48 ± 1.30 1.80 ± 0.80 CDMA 2.5 7.35 ± 2.47 0.339 4.40 ± 2.06 5 7.87 ± 2.80 0.404 4.60 ± 2.34 10 5.43 ± 2.43 0.431 1.60 ± 0.93 P=0.554 Liver Sham Control 0 16.30 ± 2.21 6.80 ± 2.82 CDMA 2.5 17.66 ± 1.89 1.000 21.60 ± 16.88 5 16.15 ± 1.15 1.000 11.00 ± 3.77 10 16.43 ± 0.83 1.000 7.20 ± 1.11 P=0.368 Peripheral Blood Sham Control 0 1.60 ± 0.68 0.40 ± 0.24 CDMA 2.5 2.10 ± 0.50 0.449 1.20 ± 0.58 5 1.30 ± 0.28 0.527 0.40 ± 0.24 10 2.86 ± 0.26 0.046 1.40 ± 0.87 P=0.057 a Study was performed at ILS, Inc. The detailed protocol (100 cell) is presented by Recio et al. (2010). Groups of five mice per exposure group were 5 to 6 weeks old when exposure began. b Mean ± standard error c Pairwise comparison with the sham control group; exposed group values are significant at P≤0.025 by Williams’ test. d No exposure to CDMA-modulated cell phone RFR e Dose-related trend; significant at P≤0.025 by linear regression. E-6 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE E2 DNA Damage in Male Mice Exposed to GSM-Modulated Cell Phone RFR for 14 Weeks (100-Cell Method)a Dose (W/kg) Percent Tail DNAb P Valuec Percent Hedgehogsb Frontal Cortex Sham Controld 0 0.63 ± 0.08 0.40 ± 0.24 GSM 2.5 1.71 ± 0.46 0.081 1.80 ± 0.97 5 1.39 ± 0.15 0.081 1.60 ± 0.81 10 3.73 ± 0.65 0.001 1.00 ± 0.45 P=0.001e Hippocampus Sham Control 0 7.69 ± 2.00 1.20 ± 0.58 GSM 2.5 8.74 ± 1.93 0.514 5.40 ± 2.11 5 7.17 ± 1.08 0.598 2.20 ± 0.97 10 6.90 ± 1.19 0.633 5.40 ± 2.54 P=0.720 Cerebellum Sham Control 0 5.48 ± 1.30 1.80 ± 0.80 GSM 2.5 3.66 ± 0.30 0.831 3.00 ± 1.38 5 3.90 ± 0.59 0.896 1.80 ± 0.92 10 3.85 ± 1.08 0.919 3.40 ± 1.50 P=0.838 Liver Sham Control 0 16.30 ± 2.21 6.80 ± 2.82 GSM 2.5 17.66 ± 1.89 0.469 8.20 ± 3.84 5 15.40 ± 1.20 0.549 6.60 ± 1.96 10 18.94 ± 2.00 0.213 12.80 ± 4.40 P=0.198 Peripheral Blood Sham Control 0 1.60 ± 0.68 0.40 ± 0.24 GSM 2.5 1.85 ± 0.96 0.416 1.20 ± 1.20 5 1.75 ± 0.37 0.491 1.00 ± 0.55 10 1.85 ± 0.24 0.494 0.80 ± 0.58 P=0.408 a Study was performed at ILS, Inc. The detailed protocol (100 cell) is presented by Recio et al. (2010). Groups of five mice per exposure group were 5 to 6 weeks old when exposure began. b Mean ± standard error c Pairwise comparison with the sham control group; exposed group values are significant at P≤0.025 by Williams’ test. d No exposure to GSM-modulated cell phone RFR e Dose-related trend; significant at P≤0.025 by linear regression. GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 E-7 Peer Review Draft NOT FOR ATTRIBUTION TABLE E3 DNA Damage in the Frontal Cortex of Male Mice Exposed to CDMA- or GSM-Modulated Cell Phone RFR for 14 Weeks (150-Cell Method)a Dose (W/kg) Percent Tail DNAb P Valuec Percent Hedgehogsb,d Sham Controle 0 1.32 ± 0.21 0 CDMA 2.5 4.52 ± 0.57 0.131 0 5 6.06 ± 0.96 0.018 0 10 10.04 ± 2.08 0.001 0.53 ± 0.39 P=0.001f GSM 2.5 4.25 ± 1.20 0.063 0.13 ± 0.13 5 3.69 ± 0.53 0.063 0 10 5.60 ± 1.28 0.006 0.13 ± 0.13 P=0.004 a Study was performed at ILS, Inc. The detailed protocol (150 cell) is presented by OECD (2014). Groups of five mice per exposure group were 5 to 6 weeks old when exposure began. b Mean ± standard error c Pairwise comparison with the sham control group; exposed group values are significant at P≤0.025 by Williams’ test. d Percent hedgehogs=estimated as the number of comets with >90% tail DNA/150 e No exposure to CDMA- or GSM-modulated cell phone RFR f Dose-related trend; significant at P≤0.025 by linear regression. E-8 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE E4 DNA Damage in Female Mice Exposed to CDMA-Modulated Cell Phone RFR for 14 Weeks (100-Cell Method)a Dose (W/kg) Percent Tail DNAb P Valuec Percent Hedgehogsb Frontal Cortex Sham Controld 0 8.11 ± 2.13 3.40 ± 1.47 CDMA 2.5 4.88 ± 0.55 0.911 0.80 ± 0.49 5 4.89 ± 0.57 0.955 1.20 ± 0.49 10 4.80 ± 0.90 0.968 0.80 ± 0.58 P=0.935e Hippocampus Sham Control 0 8.15 ± 1.65 2.60 ± 1.69 CDMA 2.5 5.76 ± 1.00 0.839 1.80 ± 0.80 5 5.22 ± 1.02 0.903 1.20 ± 0.58 10 5.34 ± 1.82 0.925 2.20 ± 0.97 P=0.892 Cerebellum Sham Control 0 5.88 ± 0.85 0.20 ± 0.20 CDMA 2.5 6.56 ± 1.22 0.296 1.75 ± 1.03 5 8.39 ± 1.13 0.194 0.20 ± 0.20 10 6.73 ± 0.77 0.207 0.40 ± 0.40 P=0.298 Liver Sham Control 0 5.48 ± 0.60 0.60 ± 0.40 CDMA 2.5 7.54 ± 0.90 0.034 1.00 ± 0.45 5 7.36 ± 0.72 0.041 4.40 ± 2.11 10 7.63 ± 0.59 0.030 2.00 ± 0.77 P=0.050 Peripheral Blood Sham Control 0 1.03 ± 0.13 0.20 ± 0.20 CDMA 2.5 2.52 ± 0.54 0.020 2.00 ± 1.14 5 1.71 ± 0.37 0.024 0 10 2.20 ± 0.19 0.018 0.20 ± 0.20 P=0.085 a Study was performed at ILS, Inc. The detailed protocol (100 cell) is presented by Recio et al. (2010). Groups of five mice per exposure group were 5 to 6 weeks old when exposure began. b Mean ± standard error c Pairwise comparison with the sham control group; exposed group values are significant at P≤0.025 by Williams’ test. d No exposure to CDMA-modulated cell phone RFR e Dose-related trend; significant at P≤0.025 by linear regression. GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 E-9 Peer Review Draft NOT FOR ATTRIBUTION TABLE E5 DNA Damage in Female Mice Exposed to GSM-Modulated Cell Phone RFR for 14 Weeks (100-Cell Method)a Dose (W/kg) Percent Tail DNAb P Valuec Percent Hedgehogsb Frontal Cortex Sham Controld 0 8.11 ± 2.13 3.40 ± 1.47 GSM 2.5 7.33 ± 0.90 0.657 1.00 ± 0.45 5 7.69 ± 1.98 0.744 2.00 ± 0.84 10 5.74 ± 0.62 0.779 1.00 ± 0.32 P=0.861e Hippocampus Sham Control 0 8.15 ± 1.65 2.60 ± 1.69 GSM 2.5 6.23 ± 1.00 0.866 0.80 ± 0.58 5 4.54 ± 1.29 0.923 1.20 ± 0.58 10 5.22 ± 1.23 0.942 1.60 ± 1.36 P=0.933 Cerebellum Sham Control 0 5.88 ± 0.85 0.20 ± 0.20 GSM 2.5 6.56 ± 1.22 1.000 1.20 ± 0.73 5 5.26 ± 0.59 1.000 0.60 ± 0.40 10 6.54 ± 1.71 1.000 1.80 ± 0.73 P=0.606 Liver Sham Control 0 5.48 ± 0.60 0.60 ± 0.40 GSM 2.5 7.06 ± 0.61 0.096 3.40 ± 1.17 5 6.36 ± 0.25 0.117 1.20 ± 0.37 10 6.47 ± 0.79 0.124 2.60 ± 1.33 P=0.249 Peripheral Blood Sham Control 0 1.03 ± 0.13 0.20 ± 0.20 GSM 2.5 1.25 ± 0.44 0.335 0.20 ± 0.20 5 1.17 ± 0.08 0.400 0 10 1.32 ± 0.34 0.316 0 P=0.266 a Study was performed at ILS, Inc. The detailed protocol (100 cell) is presented by Recio et al. (2010). Groups of five mice per exposure group were 5 to 6 weeks old when exposure began. b Mean ± standard error c Pairwise comparison with the sham control group; exposed group values are significant at P≤0.025 by Williams’ test. d No exposure to GSM-modulated cell phone RFR e Dose-related trend; significant at P≤0.025 by linear regression. E-10 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE E6 DNA Damage in Female Mice Exposed to CDMA- or GSM-Modulated Cell Phone RFR for 14 Weeks (150-Cell Method)a Dose (W/kg) Percent Tail DNAb P Valuec Percent Hedgehogsb,d Liver Sham Controle 0 4.34 ± 0.60 0 CDMA 2.5 6.80 ± 1.17 0.146 0 5 7.70 ± 0.95 0.010 0 10 6.14 ± 0.26 0.131 0 P=0.030f GSM 2.5 7.44 ± 0.48 0.027 0 5 5.45 ± 0.96 0.032 0 10 6.52 ± 0.75 0.030 0 P=0.133 Peripheral Blood Sham Control 0 2.15 ± 0.08 0 CDMA 2.5 3.62 ± 0.66 0.011 0 5 3.39 ± 0.45 0.015 0.13 ± 0.13 10 2.45 ± 0.24 0.428 0 P=0.173 GSM 2.5 2.58 ± 0.35 0.504 0 5 2.23 ± 0.19 1.000 0 10 2.28 ± 0.51 1.000 0 P=0.657 a Study was performed at ILS, Inc. The detailed protocol (150 cell) is presented by OECD (2014). Groups of five mice per exposure group were 5 to 6 weeks old when exposure began. b Mean ± standard error c Pairwise comparison with the sham control group; exposed group values are significant at P≤0.025 by Williams’ test. d Percent hedgehogs=estimated as the number of comets with >90% tail DNA/150 e No exposure to CDMA- or GSM-modulated cell phone RFR f Dose-related trend; significant at P≤0.025 by linear regression. GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 E-11 Peer Review Draft NOT FOR ATTRIBUTION TABLE E7 Frequency of Micronuclei in Peripheral Blood Erythrocytes of Mice Following Exposure to CDMA- or GSM-Modulated Cell Phone RFR for 14 Weeksa Dose (W/kg) Number of Mice with Erythrocytes Scored Micronucleated PCEs/ 1,000 PCEsb P Valuec Micronucleated NCEs/ 1,000 NCEsb P Valuec PCEsb (%) P Valuec Male Sham Controld 0 5 2.55 ± 0.11 1.50 ± 0.04 1.45 ± 0.05 CDMA 2.5 5 2.44 ± 0.13 0.611 1.45 ± 0.03 0.748 1.47 ± 0.04 0.765 5 5 2.77 ± 0.13 0.168 1.46 ± 0.04 0.827 1.50 ± 0.04 0.736 10 5 2.93 ± 0.18 0.044 1.49 ± 0.02 0.736 1.47 ± 0.04 0.778 P=0.013e P=0.497 P=0.803 GSM 2.5 5 2.84 ± 0.14 0.384 1.49 ± 0.04 0.695 1.41 ± 0.04 0.667 5 5 2.47 ± 0.19 0.455 1.45 ± 0.02 0.781 1.40 ± 0.04 0.787 10 5 2.53 ± 0.13 0.484 1.50 ± 0.02 0.675 1.47 ± 0.08 0.830 P=0.733 P=0.561 P=0.803 Female Sham Control 0 5 2.72 ± 0.27 1.18 ± 0.02 1.33 ± 0.11 CDMA 2.5 5 2.16 ± 0.15 0.846 1.06 ± 0.04 0.956 1.33 ± 0.13 1.000 5 5 2.32 ± 0.22 0.908 1.09 ± 0.03 0.982 1.45 ± 0.11 0.930 10 5 2.48 ± 0.20 0.883 1.14 ± 0.02 0.929 1.28 ± 0.09 0.935 P=0.629 P=0.585 P=0.843 GSM 2.5 5 2.50 ± 0.40 0.774 1.14 ± 0.05 0.827 1.19 ± 0.08 0.671 5 5 2.35 ± 0.15 0.850 1.09 ± 0.02 0.893 1.17 ± 0.06 0.791 10 5 2.16 ± 0.15 0.878 1.12 ± 0.04 0.916 1.45 ± 0.09 0.438 P=0.937 P=0.891 P=0.245 a Study was performed at ILS, Inc. The detailed protocol is presented by Witt et al. (2008). Mice were 5 to 6 weeks old when exposure began. NCE=normochromatic erythrocyte; PCE=polychromatic erythrocyte b Mean ± standard error c Pairwise comparison with the sham control group; exposed group values are significant at P≤0.025 by Williams’ test. d No exposure to CDMA- or GSM-modulated cell phone RFR e Dose-related trend significant at P≤0.025 by linear regression E-12 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft F-1 Peer Review Draft NOT FOR ATTRIBUTION APPENDIX F HEMATOLOGY RESULTS TABLE F1 Hematology Data for Mice at the 14-Week Interim Evaluation in the 2-Year GSM-Modulated Cell Phone RFR Study..................................................................F-2 TABLE F2 Hematology Data for Mice at the 14-Week Interim Evaluation in the 2-Year CDMA-Modulated Cell Phone RFR Study...............................................................F-3 F-2 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE F1 Hematology Data for Mice at the 14-Week Interim Evaluation in the 2-Year GSM-Modulated Cell Phone RFR Studya Sham Control 2.5 W/kg 5 W/kg 10 W/kg n 10 10 10 10 Male Hematocrit (%) 54.8 ± 0.5 54.1 ± 0.9 54.2 ± 0.3 53.5 ± 0.5 Manual hematocrit (%) 50 ± 0 49 ± 1b 49 ± 0 49 ± 0 Hemoglobin (g/dL) 16.1 ± 0.1 16.0 ± 0.2 16.0 ± 0.1 15.9 ± 0.2 Erythrocytes (106/µL) 10.87 ± 0.09 10.66 ± 0.15 10.76 ± 0.06 10.61 ± 0.10 Reticulocytes (103/µL) 386.3 ± 8.2 363.6 ± 9.3 358.5 ± 7.5 357.9 ± 7.9 Nucleated erythrocytes (/100 leukocytes) 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 Mean cell volume (fL) 50.4 ± 0.1 50.8 ± 0.2 50.4 ± 0.2 50.4 ± 0.2 Mean cell hemoglobin (pg) 14.8 ± 0.0 15.0 ± 0.1 14.9 ± 0.1 15.0 ± 0.1 Mean cell hemoglobin concentration (g/dL) 29.4 ± 0.1 29.5 ± 0.1 29.5 ± 0.1 29.7 ± 0.1 Platelets (103/µL) 1,115 ± 31 1,065 ± 30 1,111 ± 35 1,116 ± 32 Leukocytes (103/µL) 5.80 ± 0.50 5.11 ± 0.53 5.52 ± 0.43 6.30 ± 0.47 Segmented neutrophils (103/µL) 0.68 ± 0.06 0.58 ± 0.07 0.62 ± 0.04 0.67 ± 0.05 Lymphocytes (103/µL) 4.82 ± 0.41 4.28 ± 0.44 4.63 ± 0.37 5.29 ± 0.40 Monocytes (103 /µL) 0.09 ± 0.01 0.09 ± 0.01 0.09 ± 0.01 0.11 ± 0.01 Basophils (103 /µL) 0.04 ± 0.01 0.04 ± 0.01 0.04 ± 0.01 0.05 ± 0.01 Eosinophils (103/µL) 0.09 ± 0.01 0.07 ± 0.01 0.08 ± 0.01 0.10 ± 0.01 Large unstained cells (103/µL) 0.07 ± 0.01 0.06 ± 0.01 0.07 ± 0.01 0.07 ± 0.01 Female Hematocrit (%) 54.9 ± 2.0 55.7 ± 0.9 55.6 ± 0.5 55.2 ± 0.4 Manual hematocrit (%) 50 ± 2 52 ± 1 52 ± 1 51 ± 0 Hemoglobin (g/dL) 16.4 ± 0.5 16.8 ± 0.3 16.8 ± 0.2 16.5 ± 0.1 Erythrocytes (106/µL) 10.77 ± 0.34 10.88 ± 0.16 10.90 ± 0.11 10.75 ± 0.07 Reticulocytes (103/µL) 346.8 ± 17.4 365.5 ± 20.0 328.6 ± 13.5 378.6 ± 15.5 Nucleated erythrocytes (/100 leukocytes) 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 Mean cell volume (fL) 50.9 ± 0.3 51.2 ± 0.2 51.1 ± 0.2 51.4 ± 0.2 Mean cell hemoglobin (pg) 15.2 ± 0.1 15.4 ± 0.1 15.4 ± 0.1 15.3 ± 0.1 Mean cell hemoglobin concentration (g/dL) 29.9 ± 0.3 30.1 ± 0.1 30.2 ± 0.1 29.8 ± 0.1 Platelets (103/µL) 758 ± 65 714 ± 37 717 ± 52 782 ± 29 Leukocytes (103/µL) 5.15 ± 0.57 5.06 ± 0.60 5.07 ± 0.57 4.88 ± 0.58 Segmented neutrophils (103/µL) 0.60 ± 0.08 0.53 ± 0.07 0.44 ± 0.07 0.58 ± 0.06 Lymphocytes (103/µL) 4.35 ± 0.49 4.30 ± 0.51 4.41 ± 0.49 4.09 ± 0.52 Monocytes (103 /µL) 0.07 ± 0.01 0.08 ± 0.01 0.08 ± 0.01 0.08 ± 0.01 Basophils (103 /µL) 0.03 ± 0.01 0.04 ± 0.00 0.04 ± 0.01 0.03 ± 0.00 Eosinophils (103/µL) 0.06 ± 0.01 0.07 ± 0.01 0.06 ± 0.01 0.06 ± 0.01 Large unstained cells (103/µL) 0.04 ± 0.01 0.04 ± 0.01 0.04 ± 0.01 0.04 ± 0.00 a Data are presented as mean ± standard error. Jonckheere’s test for trend and Shirley’s and Dunn’s tests were performed on unrounded data. b n=9 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 F-3 Peer Review Draft NOT FOR ATTRIBUTION TABLE F2 Hematology Data for Mice at the 14-Week Interim Evaluation in the 2-Year CDMA-Modulated Cell Phone RFR Studya Sham Control 2.5 W/kg 5 W/kg 10 W/kg n 10 10 10 10 Male Hematocrit (%) 54.8 ± 0.5 54.6 ± 0.6 54.0 ± 0.6 54.5 ± 0.6 Manual hematocrit (%) 50 ± 0 50 ± 1 49 ± 1 50 ± 1 Hemoglobin (g/dL) 16.1 ± 0.1 16.0 ± 0.2 16.0 ± 0.2 16.1 ± 0.2 Erythrocytes (106/µL) 10.87 ± 0.09 10.77 ± 0.09 10.68 ± 0.12 10.76 ± 0.11 Reticulocytes (103/µL) 386.3 ± 8.2 367.1 ± 9.0 360.3 ± 8.8 374.6 ± 6.3 Nucleated erythrocytes (/100 leukocytes) 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 Mean cell volume (fL) 50.4 ± 0.1 50.7 ± 0.2 50.6 ± 0.1 50.7 ± 0.2 Mean cell hemoglobin (pg) 14.8 ± 0.0 14.9 ± 0.1 14.9 ± 0.1 15.0 ± 0.1 Mean cell hemoglobin concentration (g/dL) 29.4 ± 0.1 29.3 ± 0.1 29.5 ± 0.1 29.6 ± 0.1 Platelets (103/µL) 1,115 ± 31 1,087 ± 36 1,128 ± 30 1,104 ± 40 Leukocytes (103/µL) 5.80 ± 0.50 5.41 ± 0.35 5.57 ± 0.43 5.45 ± 0.44 Segmented neutrophils (103/µL) 0.68 ± 0.06 0.59 ± 0.04 0.62 ± 0.05 0.58 ± 0.05 Lymphocytes (103/µL) 4.82 ± 0.41 4.57 ± 0.31 4.67 ± 0.38 4.57 ± 0.36 Monocytes (103 /µL) 0.09 ± 0.01 0.09 ± 0.01 0.10 ± 0.01 0.09 ± 0.01 Basophils (103 /µL) 0.04 ± 0.01 0.03 ± 0.01 0.04 ± 0.01 0.05 ± 0.01 Eosinophils (103/µL) 0.09 ± 0.01 0.07 ± 0.01 0.09 ± 0.01 0.09 ± 0.02 Large unstained cells (103/µL) 0.07 ± 0.01 0.06 ± 0.01 0.07 ± 0.01 0.07 ± 0.01 Female Hematocrit (%) 54.9 ± 2.0 55.2 ± 0.8 56.4 ± 0.6 56.1 ± 0.4 Manual hematocrit (%) 50 ± 2 52 ± 1 52 ± 1 52 ± 0 Hemoglobin (g/dL) 16.4 ± 0.5 16.6 ± 0.2 17.0 ± 0.2 16.8 ± 0.2 Erythrocytes (106/µL) 10.77 ± 0.34 10.78 ± 0.14 11.10 ± 0.11 10.96 ± 0.06 Reticulocytes (103/µL) 346.8 ± 17.4 371.2 ± 14.4 366.7 ± 20.6 374.7 ± 13.8 Nucleated erythrocytes (/100 leukocytes) 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 Mean cell volume (fL) 50.9 ± 0.3 51.2 ± 0.2 50.8 ± 0.2 51.2 ± 0.1 Mean cell hemoglobin (pg) 15.2 ± 0.1 15.4 ± 0.1 15.3 ± 0.1 15.3 ± 0.1 Mean cell hemoglobin concentration (g/dL) 29.9 ± 0.3 30.1 ± 0.1 30.1 ± 0.1 29.9 ± 0.2 Platelets (103/µL) 758 ± 65 736 ± 53 668 ± 38 685 ± 41 Leukocytes (103/µL) 5.15 ± 0.57 5.24 ± 0.45 4.66 ± 0.55 4.53 ± 0.34 Segmented neutrophils (103/µL) 0.60 ± 0.08 0.52 ± 0.04 0.51 ± 0.08 0.42 ± 0.05 Lymphocytes (103/µL) 4.35 ± 0.49 4.52 ± 0.40 3.95 ± 0.46 3.92 ± 0.31 Monocytes (103 /µL) 0.07 ± 0.01 0.07 ± 0.01 0.07 ± 0.01 0.07 ± 0.01 Basophils (103 /µL) 0.03 ± 0.01 0.04 ± 0.00 0.03 ± 0.01 0.03 ± 0.01 Eosinophils (103/µL) 0.06 ± 0.01 0.06 ± 0.01 0.06 ± 0.01 0.06 ± 0.01 Large unstained cells (103/µL) 0.04 ± 0.01 0.04 ± 0.00 0.04 ± 0.01 0.04 ± 0.00 a Data are presented as mean ± standard error. Jonckheere’s test for trend and Shirley’s and Dunn’s tests were performed on unrounded data. F-4 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft G-1 Peer Review Draft NOT FOR ATTRIBUTION APPENDIX G ORGAN WEIGHTS AND ORGAN-WEIGHT-TO-BODY-WEIGHT RATIOS TABLE G1 Organ Weights and Organ-Weight-to-Body-Weight Ratios for Mice in the 28-Day GSM-Modulated Cell Phone RFR Study ................................................................ G-2 TABLE G2 Organ Weights and Organ-Weight-to-Body-Weight Ratios for Mice at the 14-Week Interim Evaluation in the 2-Year GSM-Modulated Cell Phone RFR Study................................................................. G-4 TABLE G3 Organ Weights and Organ-Weight-to-Body-Weight Ratios for Mice in the 28-Day CDMA-Modulated Cell Phone RFR Study ............................................................. G-6 TABLE G4 Organ Weights and Organ-Weight-to-Body-Weight Ratios for Mice at the 14-Week Interim Evaluation in the 2-Year CDMA-Modulated Cell Phone RFR Study.............................................................. G-8 G-2 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE G1 Organ Weights and Organ-Weight-to-Body-Weight Ratios for Mice in the 28-Day GSM-Modulated Cell Phone RFR Studya Sham Control 5 W/kg 10 W/kg 15 W/kg n 10 10 10 10 Male Necropsy body wt. 24.9 ± 0.4 25.2 ± 0.4 24.7 ± 0.3 25.0 ± 0.4 R. Adrenal gland Absolute 0.0032 ± 0.0006 0.0025 ± 0.0003 0.0031 ± 0.0006b 0.0030 ± 0.0003 Relative 0.13 ± 0.02 0.10 ± 0.01 0.12 ± 0.02b 0.12 ± 0.01 Brain Absolute 0.47 ± 0.00 0.47 ± 0.00 0.47 ± 0.00 0.47 ± 0.00 Relative 19.06 ± 0.28 18.63 ± 0.24 18.86 ± 0.25 18.78 ± 0.33 Heart Absolute 0.14 ± 0.00 0.14 ± 0.00 0.14 ± 0.00 0.14 ± 0.00 Relative 5.59 ± 0.14 5.41 ± 0.14 5.50 ± 0.10 5.57 ± 0.15 R. Kidney Absolute 0.22 ± 0.01 0.23 ± 0.00 0.22 ± 0.00 0.22 ± 0.01 Relative 8.80 ± 0.14 9.07 ± 0.14 8.90 ± 0.12 8.64 ± 0.15 Liver Absolute 1.29 ± 0.03 1.29 ± 0.03 1.25 ± 0.03 1.23 ± 0.03 Relative 51.86 ± 0.73 51.24 ± 0.80 50.63 ± 0.94 49.16 ± 0.95 Lung Absolute 0.20 ± 0.01 0.19 ± 0.01b 0.20 ± 0.01 0.19 ± 0.01 Relative 7.87 ± 0.35 7.44 ± 0.41b 8.14 ± 0.45 7.45 ± 0.54 R. Testis Absolute 0.094 ± 0.005 0.097 ± 0.002 0.093 ± 0.005 0.097 ± 0.002 Relative 3.79 ± 0.21 3.88 ± 0.09 3.75 ± 0.21 3.87 ± 0.06 Thymus Absolute 0.045 ± 0.002 0.046 ± 0.001 0.046 ± 0.001 0.047 ± 0.002 Relative 1.81 ± 0.06 1.84 ± 0.04 1.84 ± 0.05 1.89 ± 0.11 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 G-3 Peer Review Draft NOT FOR ATTRIBUTION TABLE G1 Organ Weights and Organ-Weight-to-Body-Weight Ratios for Mice in the 28-Day GSM-Modulated Cell Phone RFR Study Sham Control 5 W/kg 10 W/kg 15 W/kg n 10 10 10 10 Female Necropsy body wt. 21.7 ± 0.3 21.9 ± 0.2 21.2 ± 0.2 21.0 ± 0.2* R. Adrenal gland Absolute 0.0037 ± 0.0006 0.0031 ± 0.0006 0.0037 ± 0.0005 0.0036 ± 0.0003 Relative 0.17 ± 0.03 0.14 ± 0.03 0.18 ± 0.02 0.17 ± 0.01 Brain Absolute 0.48 ± 0.00 0.49 ± 0.00 0.47 ± 0.00 0.47 ± 0.00 Relative 22.24 ± 0.32 22.15 ± 0.18 22.21 ± 0.24 22.56 ± 0.27 Heart Absolute 0.13 ± 0.00 0.13 ± 0.00 0.12 ± 0.00 0.12 ± 0.00* Relative 6.00 ± 0.19 5.85 ± 0.11 5.77 ± 0.12 5.62 ± 0.17 R. Kidney Absolute 0.17 ± 0.00 0.16 ± 0.00 0.15 ± 0.00 0.16 ± 0.00 Relative 7.65 ± 0.18 7.44 ± 0.13 7.27 ± 0.18 7.39 ± 0.11 Liver Absolute 1.14 ± 0.03 1.18 ± 0.02 1.10 ± 0.02 1.07 ± 0.03 Relative 52.61 ± 0.66 53.72 ± 0.85 51.77 ± 0.92 50.72 ± 0.95 Lung Absolute 0.18 ± 0.01 0.19 ± 0.01 0.17 ± 0.01 0.17 ± 0.00 Relative 8.48 ± 0.45 8.45 ± 0.34 8.18 ± 0.25 8.06 ± 0.19 Thymus Absolute 0.056 ± 0.001 0.057 ± 0.001 0.054 ± 0.001 0.055 ± 0.002 Relative 2.57 ± 0.07 2.59 ± 0.04 2.53 ± 0.07 2.62 ± 0.11 * Significantly different (P≤0.05) from the sham control group by Williams’ or Dunnett’s test a Organ weights (absolute weights) and body weights are given in grams; organ-weight-to-body-weight ratios (relative weights) are given as mg organ weight/g body weight (mean ± standard error). b n=9 G-4 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE G2 Organ Weights and Organ-Weight-to-Body-Weight Ratios for Mice at the 14-Week Interim Evaluation in the 2-Year GSM-Modulated Cell Phone RFR Studya Sham Control 2.5 W/kg 5 W/kg 10 W/kg n 10 10 10 10 Male Necropsy body wt. 34.8 ± 0.8 33.3 ± 0.8 34.3 ± 0.6 33.0 ± 0.5 Brain Absolute 0.48 ± 0.01 0.48 ± 0.00 0.47 ± 0.00 0.47 ± 0.01 Relative 13.74 ± 0.43 14.44 ± 0.39 13.73 ± 0.28 14.18 ± 0.22 R. Epididymis Absolute 0.0504 ± 0.0024 0.0466 ± 0.0023 0.0471 ± 0.0029 0.0489 ± 0.0016 Relative 1.45 ± 0.06 1.40 ± 0.05 1.37 ± 0.07 1.49 ± 0.05 L. Epididymis Absolute 0.0478 ± 0.0019 0.0499 ± 0.0026 0.0500 ± 0.0026 0.0468 ± 0.0023 Relative 1.38 ± 0.06 1.50 ± 0.07 1.46 ± 0.07 1.43 ± 0.09 Heart Absolute 0.16 ± 0.00b 0.17 ± 0.01 0.16 ± 0.00b 0.16 ± 0.01 Relative 4.52 ± 0.09b 5.06 ± 0.18 4.75 ± 0.13b 4.87 ± 0.21 R. Kidney Absolute 0.27 ± 0.01 0.26 ± 0.01 0.25 ± 0.00* 0.25 ± 0.01** Relative 7.80 ± 0.17 7.89 ± 0.18 7.44 ± 0.14 7.63 ± 0.19 L. Kidney Absolute 0.26 ± 0.01 0.25 ± 0.01 0.25 ± 0.01 0.23 ± 0.00** Relative 7.54 ± 0.15 7.65 ± 0.15 7.20 ± 0.16 7.08 ± 0.16 Liver Absolute 1.54 ± 0.05 1.44 ± 0.05 1.38 ± 0.03*b 1.39 ± 0.03*b Relative 44.27 ± 0.73 43.18 ± 0.85 40.73 ± 0.82*b 42.31 ± 1.01b Lung Absolute 0.28 ± 0.02 0.29 ± 0.02 0.24 ± 0.01 0.27 ± 0.02 Relative 7.84 ± 0.58 8.62 ± 0.58 6.98 ± 0.34 8.24 ± 0.68 R. Testis Absolute 0.110 ± 0.002 0.111 ± 0.004 0.102 ± 0.008 0.109 ± 0.002 Relative 3.16 ± 0.10 3.34 ± 0.11 2.98 ± 0.22 3.31 ± 0.09 L. Testis Absolute 0.104 ± 0.002 0.107 ± 0.002 0.101 ± 0.007 0.105 ± 0.002 Relative 3.01 ± 0.12 3.22 ± 0.09 2.96 ± 0.21 3.20 ± 0.09 Thymus Absolute 0.035 ± 0.002 0.037 ± 0.002 0.037 ± 0.002 0.036 ± 0.002 Relative 1.02 ± 0.07 1.10 ± 0.04 1.07 ± 0.05 1.10 ± 0.04 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 G-5 Peer Review Draft NOT FOR ATTRIBUTION TABLE G2 Organ Weights and Organ-Weight-to-Body-Weight Ratios for Mice at the 14-Week Interim Evaluation in the 2-Year GSM-Modulated Cell Phone RFR Study Sham Control 2.5 W/kg 5 W/kg 10 W/kg n 10 10 10 10 Female Necropsy body wt. 24.4 ± 0.4 24.9 ± 0.5 25.0 ± 0.5 26.2 ± 0.7* Brain Absolute 0.49 ± 0.00 0.49 ± 0.00 0.49 ± 0.00 0.49 ± 0.01 Relative 20.21 ± 0.32 19.85 ± 0.37 19.78 ± 0.36 18.86 ± 0.40* Heart Absolute 0.15 ± 0.01 0.16 ± 0.01 0.16 ± 0.01 0.16 ± 0.01 Relative 6.24 ± 0.25 6.34 ± 0.25 6.31 ± 0.22 6.11 ± 0.28 R. Kidney Absolute 0.18 ± 0.00 0.18 ± 0.00 0.17 ± 0.00 0.17 ± 0.01 Relative 7.26 ± 0.13 7.08 ± 0.18 6.92 ± 0.23 6.65 ± 0.17* L. Kidney Absolute 0.16 ± 0.00 0.16 ± 0.00 0.15 ± 0.00 0.16 ± 0.01 Relative 6.52 ± 0.16 6.35 ± 0.08 6.19 ± 0.15 6.20 ± 0.16 Liver Absolute 1.21 ± 0.03 1.24 ± 0.03 1.22 ± 0.02 1.28 ± 0.05 Relative 49.60 ± 0.66 49.76 ± 0.59 48.96 ± 0.75 48.94 ± 1.28 Lung Absolute 0.31 ± 0.02 0.34 ± 0.02 0.32 ± 0.01 0.31 ± 0.01 Relative 12.59 ± 0.60 13.45 ± 0.73 12.75 ± 0.39 11.75 ± 0.60 R. Ovary Absolute 0.0077 ± 0.0004 0.0072 ± 0.0006 0.0067 ± 0.0009 0.0070 ± 0.0006 Relative 0.32 ± 0.02 0.29 ± 0.02 0.27 ± 0.04 0.27 ± 0.02 L. Ovary Absolute 0.0069 ± 0.0009 0.0058 ± 0.0006 0.0053 ± 0.0008 0.0064 ± 0.0003 Relative 0.28 ± 0.04 0.23 ± 0.02 0.21 ± 0.03 0.25 ± 0.01 Thymus Absolute 0.041 ± 0.003 0.044 ± 0.001 0.043 ± 0.002 0.049 ± 0.002* Relative 1.66 ± 0.10 1.75 ± 0.04 1.73 ± 0.04 1.86 ± 0.06 * Significantly different (P≤0.05) from the sham control group by Williams’ or Dunnett’s test ** P≤0.01 a Organ weights (absolute weights) and body weights are given in grams; organ-weight-to-body-weight ratios (relative weights) are given as mg organ weight/g body weight (mean ± standard error). b n=9 G-6 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE G3 Organ Weights and Organ-Weight-to-Body-Weight Ratios for Mice in the 28-Day CDMA-Modulated Cell Phone RFR Studya Sham Control 5 W/kg 10 W/kg 15 W/kg n 10 10 10 10 Male Necropsy body wt. 24.9 ± 0.4 24.3 ± 0.3 25.2 ± 0.4 25.1 ± 0.3 R. Adrenal gland Absolute 0.0032 ± 0.0006 0.0025 ± 0.0002 0.0026 ± 0.0006 0.0030 ± 0.0006b Relative 0.13 ± 0.02 0.10 ± 0.01 0.10 ± 0.02 0.12 ± 0.02b Brain Absolute 0.47 ± 0.00 0.46 ± 0.00 0.48 ± 0.00 0.47 ± 0.00 Relative 19.06 ± 0.28 19.14 ± 0.13 19.11 ± 0.25 18.52 ± 0.24 Heart Absolute 0.14 ± 0.00 0.13 ± 0.00 0.14 ± 0.00 0.14 ± 0.00 Relative 5.59 ± 0.14 5.52 ± 0.12 5.40 ± 0.12 5.58 ± 0.14 R. Kidney Absolute 0.22 ± 0.01 0.21 ± 0.01 0.22 ± 0.01 0.22 ± 0.01 Relative 8.80 ± 0.14 8.77 ± 0.16 8.86 ± 0.20 8.67 ± 0.20 Liver Absolute 1.29 ± 0.03 1.24 ± 0.02 1.29 ± 0.02 1.25 ± 0.02 Relative 51.86 ± 0.73 51.26 ± 0.73 51.20 ± 0.82 49.85 ± 0.77 Lung Absolute 0.20 ± 0.01 0.18 ± 0.00 0.19 ± 0.01 0.18 ± 0.00 Relative 7.87 ± 0.35 7.55 ± 0.16 7.45 ± 0.24 7.13 ± 0.16 R. Testis Absolute 0.094 ± 0.005 0.094 ± 0.003 0.099 ± 0.001 0.096 ± 0.003 Relative 3.79 ± 0.21 3.88 ± 0.13 3.94 ± 0.09 3.81 ± 0.11 Thymus Absolute 0.045 ± 0.002 0.045 ± 0.001 0.046 ± 0.002 0.043 ± 0.001 Relative 1.81 ± 0.06 1.86 ± 0.04 1.85 ± 0.10 1.71 ± 0.04 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 G-7 Peer Review Draft NOT FOR ATTRIBUTION TABLE G3 Organ Weights and Organ-Weight-to-Body-Weight Ratios for Mice in the 28-Day CDMA-Modulated Cell Phone RFR Study Sham Control 5 W/kg 10 W/kg 15 W/kg n 10 10 10 10 Female Necropsy body wt. 21.7 ± 0.3 21.7 ± 0.3 21.6 ± 0.3 21.2 ± 0.3 R. Adrenal gland Absolute 0.0037 ± 0.0006 0.0044 ± 0.0005 0.0037 ± 0.0005 0.0037 ± 0.0005 Relative 0.17 ± 0.03 0.20 ± 0.02 0.17 ± 0.03 0.17 ± 0.02 Brain Absolute 0.48 ± 0.00 0.48 ± 0.00 0.48 ± 0.00 0.48 ± 0.00 Relative 22.24 ± 0.32 22.26 ± 0.37 22.29 ± 0.29 22.48 ± 0.29 Heart Absolute 0.13 ± 0.00 0.12 ± 0.00 0.13 ± 0.00 0.12 ± 0.00 Relative 6.00 ± 0.19 5.73 ± 0.17 5.89 ± 0.16 5.81 ± 0.13 R. Kidney Absolute 0.17 ± 0.00 0.16 ± 0.00 0.16 ± 0.00 0.15 ± 0.00* Relative 7.65 ± 0.18 7.21 ± 0.14 7.39 ± 0.23 7.24 ± 0.13 Liver Absolute 1.14 ± 0.03 1.14 ± 0.02 1.13 ± 0.02 1.09 ± 0.02 Relative 52.61 ± 0.66 52.79 ± 0.74 52.63 ± 0.68 51.27 ± 0.66 Lung Absolute 0.18 ± 0.01 0.20 ± 0.01 0.19 ± 0.01 0.17 ± 0.00 Relative 8.48 ± 0.45 9.14 ± 0.34 8.78 ± 0.40 8.18 ± 0.22 Thymus Absolute 0.056 ± 0.001 0.055 ± 0.002 0.054 ± 0.002 0.052 ± 0.002 Relative 2.57 ± 0.07 2.53 ± 0.08 2.52 ± 0.08 2.47 ± 0.08 * Significantly different (P≤0.05) from the sham control group by Williams’ or Dunnett’s test a Organ weights (absolute weights) and body weights are given in grams; organ-weight-to-body-weight ratios (relative weights) are given as mg organ weight/g body weight (mean ± standard error). b n=9 G-8 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE G4 Organ Weights and Organ-Weight-to-Body-Weight Ratios for Mice at the 14-Week Interim Evaluation in the 2-Year CDMA-Modulated Cell Phone RFR Studya Sham Control 2.5 W/kg 5 W/kg 10 W/kg n 10 10 10 10 Male Necropsy body wt. 34.8 ± 0.8 35.5 ± 0.4 33.2 ± 0.7 36.2 ± 0.7 Brain Absolute 0.48 ± 0.01 0.48 ± 0.01 0.47 ± 0.00 0.47 ± 0.00 Relative 13.74 ± 0.43 13.46 ± 0.21 14.15 ± 0.30 13.09 ± 0.26 R. Epididymis Absolute 0.0504 ± 0.0024 0.0499 ± 0.0020b 0.0472 ± 0.0021b 0.0521 ± 0.0036 Relative 1.45 ± 0.06 1.41 ± 0.07b 1.43 ± 0.08b 1.44 ± 0.10 L. Epididymis Absolute 0.0478 ± 0.0019 0.0510 ± 0.0020 0.0467 ± 0.0011 0.0508 ± 0.0033 Relative 1.38 ± 0.06 1.44 ± 0.05 1.41 ± 0.03 1.40 ± 0.09 Heart Absolute 0.16 ± 0.00b 0.16 ± 0.00b 0.16 ± 0.00 0.16 ± 0.01 Relative 4.52 ± 0.09b 4.65 ± 0.11b 4.70 ± 0.10 4.35 ± 0.09 R. Kidney Absolute 0.27 ± 0.01 0.28 ± 0.00 0.25 ± 0.01* 0.25 ± 0.01 Relative 7.80 ± 0.17 7.99 ± 0.16 7.54 ± 0.17 6.99 ± 0.17** L. Kidney Absolute 0.26 ± 0.01 0.27 ± 0.01b 0.24 ± 0.00** 0.24 ± 0.00** Relative 7.54 ± 0.15 7.57 ± 0.23b 7.10 ± 0.17 6.57 ± 0.12** Liver Absolute 1.54 ± 0.05 1.58 ± 0.06 1.39 ± 0.04* 1.49 ± 0.04 Relative 44.27 ± 0.73 44.37 ± 1.38 41.76 ± 0.70 41.25 ± 0.85* Lung Absolute 0.28 ± 0.02 0.28 ± 0.02 0.27 ± 0.02 0.31 ± 0.03 Relative 7.84 ± 0.58 7.84 ± 0.55 8.13 ± 0.46 8.62 ± 0.80 R. Testis Absolute 0.110 ± 0.002 0.109 ± 0.005 0.110 ± 0.003 0.110 ± 0.003 Relative 3.16 ± 0.10 3.09 ± 0.14 3.31 ± 0.10 3.04 ± 0.09 L. Testis Absolute 0.104 ± 0.002 0.106 ± 0.005 0.105 ± 0.001 0.109 ± 0.002 Relative 3.01 ± 0.12 2.99 ± 0.14 3.18 ± 0.07 3.01 ± 0.07 Thymus Absolute 0.035 ± 0.002 0.035 ± 0.002 0.033 ± 0.001 0.043 ± 0.002* Relative 1.02 ± 0.07 1.00 ± 0.06 1.00 ± 0.03 1.18 ± 0.05 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 G-9 Peer Review Draft NOT FOR ATTRIBUTION TABLE G4 Organ Weights and Organ-Weight-to-Body-Weight Ratios for Mice at the 14-Week Interim Evaluation in the 2-Year CDMA-Modulated Cell Phone RFR Study Sham Control 2.5 W/kg 5 W/kg 10 W/kg n 10 10 10 10 Female Necropsy body wt. 24.4 ± 0.4 25.5 ± 0.5 25.7 ± 0.7 24.5 ± 0.3 Brain Absolute 0.49 ± 0.00 0.50 ± 0.01 0.49 ± 0.01 0.49 ± 0.00 Relative 20.21 ± 0.32 19.64 ± 0.50 19.28 ± 0.42 20.04 ± 0.27 Heart Absolute 0.15 ± 0.01 0.17 ± 0.01 0.16 ± 0.01 0.15 ± 0.00 Relative 6.24 ± 0.25 6.50 ± 0.15 6.30 ± 0.28 6.11 ± 0.16 R. Kidney Absolute 0.18 ± 0.00 0.18 ± 0.01 0.18 ± 0.00 0.16 ± 0.00 Relative 7.26 ± 0.13 7.16 ± 0.17 7.13 ± 0.22 6.68 ± 0.17 L. Kidney Absolute 0.16 ± 0.00 0.17 ± 0.00 0.17 ± 0.00 0.15 ± 0.00 Relative 6.52 ± 0.16 6.54 ± 0.11 6.47 ± 0.20 6.20 ± 0.16 Liver Absolute 1.21 ± 0.03 1.26 ± 0.03 1.25 ± 0.02 1.17 ± 0.04 Relative 49.60 ± 0.66 49.38 ± 0.72 48.97 ± 0.89 47.65 ± 1.15 Lung Absolute 0.31 ± 0.02 0.33 ± 0.02 0.33 ± 0.01 0.31 ± 0.01 Relative 12.59 ± 0.60 13.03 ± 0.48 12.87 ± 0.40 12.67 ± 0.52 R. Ovary Absolute 0.0077 ± 0.0004 0.0080 ± 0.0007 0.0071 ± 0.0007 0.0068 ± 0.0005 Relative 0.32 ± 0.02 0.32 ± 0.03 0.28 ± 0.03 0.28 ± 0.02 L. Ovary Absolute 0.0069 ± 0.0009 0.0068 ± 0.0005 0.0060 ± 0.0006 0.0055 ± 0.0005 Relative 0.28 ± 0.04 0.27 ± 0.02 0.23 ± 0.03 0.22 ± 0.02 Thymus Absolute 0.041 ± 0.003 0.043 ± 0.002 0.044 ± 0.002 0.045 ± 0.001 Relative 1.66 ± 0.10 1.70 ± 0.04 1.71 ± 0.05 1.83 ± 0.05 * Significantly different (P≤0.05) from the sham control group by Williams’ or Dunnett’s test ** P≤0.01 a Organ weights (absolute weights) and body weights are given in grams; organ-weight-to-body-weight ratios (relative weights) are given as mg organ weight/g body weight (mean ± standard error). b n=9 G-10 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft H-1 Peer Review Draft NOT FOR ATTRIBUTION APPENDIX H REPRODUCTIVE TISSUE EVALUATIONS AND ESTROUS CYCLE CHARACTERIZATION TABLE H1 Summary of Reproductive Tissue Evaluations for Male Mice at the 14-Week Interim Evaluation in the 2-Year GSM-Modulated Cell Phone RFR Study................................................................. H-2 TABLE H2 Estrous Cycle Characterization for Female Mice at the 14-Week Interim Evaluation in the 2-Year GSM-Modulated Cell Phone RFR Study................................................................. H-2 FIGURE H1 Vaginal Cytology Plots for Female Mice at the 14-Week Interim Evaluation in the 2-Year GSM-Modulated Cell Phone RFR Study................................................................. H-3 TABLE H3 Results of Vaginal Cytology Study Using the Transition Matrix Approach in Female Mice at the 14-Week Interim Evaluation in the 2-Year GSM-Modulated Cell Phone RFR Study................................................................. H-4 TABLE H4 Summary of Reproductive Tissue Evaluations for Male Mice at the 14-Week Interim Evaluation in the 2-Year CDMA-Modulated Cell Phone RFR Study.............................................................. H-5 TABLE H5 Estrous Cycle Characterization for Female Mice at the 14-Week Interim Evaluation in the 2-Year CDMA-Modulated Cell Phone RFR Study.............................................................. H-5 FIGURE H2 Vaginal Cytology Plots for Female Mice at the 14-Week Interim Evaluation in the 2-Year CDMA-Modulated Cell Phone RFR Study.............................................................. H-6 TABLE H6 Results of Vaginal Cytology Study Using the Transition Matrix Approach in Female Mice at the 14-Week Interim Evaluation in the 2-Year CDMA-Modulated Cell Phone RFR Study.............................................................. H-7 H-2 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE H1 Summary of Reproductive Tissue Evaluations for Male Mice at the 14-Week Interim Evaluation in the 2-Year GSM-Modulated Cell Phone RFR Studya Sham Control 2.5 W/kg 5 W/kg 10 W/kg n 10 10 10 10 Weights (g) Necropsy body wt 34.8 ± 0.8 33.3 ± 0.8 34.3 ± 0.6 33.0 ± 0.5 L. Cauda epididymis 0.020 ± 0.001 0.020 ± 0.001 0.021 ± 0.001 0.019 ± 0.001 L. Epididymis 0.048 ± 0.002 0.050 ± 0.003 0.050 ± 0.003 0.047 ± 0.002 L. Testis 0.104 ± 0.002 0.107 ± 0.002 0.101 ± 0.007 0.105 ± 0.002 Spermatid measurements Spermatid heads (106/testis) 21.9 ± 1.9 22.2 ± 1.6 20.2 ± 3.0 22.4 ± 1.4 Spermatid heads (103/mg testis) 210.6 ± 17.0 208.2 ± 13.9 186.4 ± 26.6 213.0 ± 12.2 Epididymal spermatozoal measurements Sperm motility (%) 73.5 ± 5.7 66.8 ± 6.1 66.2 ± 7.9 76.8 ± 5.0 Sperm (106 /cauda epididymis) 24.2 ± 4.7 18.0 ± 3.2 18.3 ± 2.2 15.9 ± 2.5 Sperm (103 /mg cauda epididymis) 1,254.1 ± 258.5 921.1 ± 164.5 880.0 ± 122.2 825.1 ± 129.7 a Data are presented as mean ± standard error. Differences from the sham control group are not significant by Williams’ or Dunnett’s test (body and tissue weights) or Dunn’s test (spermatid and epididymal spermatozoal measurements). TABLE H2 Estrous Cycle Characterization for Female Mice at the 14-Week Interim Evaluation in the 2-Year GSM-Modulated Cell Phone RFR Studya Sham Control 2.5 W/kg 5 W/kg 10 W/kg Number weighed at necropsy 10 10 10 10 Necropsy body wt (g) 24.4 ± 0.4 24.9 ± 0.5 25.0 ± 0.5 26.2 ± 0.7* Proportion of regular cycling femalesb 10/10 10/10 10/10 10/10 Estrous cycle length (days) 4.0 ± 0.05 4.0 ± 0.03 4.2 ± 0.22 4.2 ± 0.21 Estrous stages (% of cycle) Diestrus 33.8 32.5 33.8 42.0 Proestrus 0.6 1.3 0.0 0.0 Estrus 51.0 49.0 49.7 47.8 Metestrus 14.6 15.9 15.9 9.6 Uncertain diagnoses 0.0 1.3 0.6 0.6 * Significantly different (P≤0.05) from the sham control group by Williams’ or Dunnett’s test a Necropsy body weights and estrous cycle length data are presented as mean ± standard error. Differences from the sham control group are not significant by Dunn’s test (estrous cycle length). Tests for equality of transition probability matrices among all groups and between the sham control group and each exposed group indicated exposed females did not have extended estrus or diestrus. b Number of females with a regular cycle/number of females cycling GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 H-3 Peer Review Draft NOT FOR ATTRIBUTION Dose (W/kg) 0 E E D E E D D E E D D E E M D E 0 E M D E D D D E E M D E E D D 0 E M D E E D E E E D D E E E D E 0 E M D E E D D E E D D E E M D E 0 E E M D E E M D E E M D E E M D 0 E E M D E E M D E E M D E E M 0 E E M D E E D D E E M D E E M D 0 E E M D E E D D E E M D E E M 0 E D D P E D D E E D D E E M D E 0 D E E D D E E D D E E M D E E M 2.5 E E I E E M D E E M D E E D D E 2.5 E M D E E M D E E D D E E M D 2.5 E M D E E D E E E D D D E M D E 2.5 E E M D E E M D E E M D E E M D 2.5 E M D P E M D E E M D E E M D 2.5 E E M D P E D D E E M D E M D 2.5 D E E M D E E E D E E D D E E M 2.5 M D E E M D E E D D E E M I E E 2.5 M D E E M D E E D D E E D D E E 2.5 D D E E D D E E D D E E D D E E 5 E E D E M D E E M D E E M D E E 5 E M D E E M D E E M D E E M D 5 E D D E E M D E E M D E E M D E 5 E E D D E E D D E E M D E E D D 5 E I D D E E D D E E M D E E D 5 E E E M D E E M D E E E M D E E 5 D E E M D E E M D E E M D E E M 5 D E E D D E E D D E E M D E E M 5 D D E E D D E E M D E E M D E 5 D E E M D D D D D D E D E E E M 10 E E D E E M D E E D D E E D D E 10 E M D E E M D E E M D E E M D 10 E M D E E D D E E D D E E M D 10 E I D E E D D E E D D E E D D E 10 D E E D D E E D D E E M D E E M 10 M D E E D D E E M D E E M D E 10 D D E E D D E E D D E E E D E E 10 D D E E E D D E E D D E E D D E 10 D D D E E D D E E M D E E M D E 10 E E D D D D D D D E M D E E D D FIGURE H1 Vaginal Cytology Plots for Female Mice at the 14-Week Interim Evaluation in the 2-Year GSM-Modulated Cell Phone RFR Study I = Insufficient number of cells to determine stage; D = diestrus, P = proestrus, E = estrus, M = metestrus H-4 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE H3 Results of Vaginal Cytology Study Using the Transition Matrix Approach in Female Mice at the 14-Week Interim Evaluation in the 2-Year GSM-Modulated Cell Phone RFR Study Stage Comparison P Value Trenda Overall Tests Overall 0.649 Overall Tests 2.5 W/kg vs. Sham Controls 0.999 Overall Tests 5 W/kg vs. Sham Controls 0.42 Overall Tests 10 W/kg vs. Sham Controls 0.291 Extended Estrus Overall 0.997 Extended Estrus 2.5 W/kg vs. Sham Controls 0.999 Extended Estrus 5 W/kg vs. Sham Controls 0.755 Extended Estrus 10 W/kg vs. Sham Controls 1 Extended Diestrus Overall 0.414 Extended Diestrus 2.5 W/kg vs. Sham Controls 1 Extended Diestrus 5 W/kg vs. Sham Controls 0.324 Extended Diestrus 10 W/kg vs. Sham Controls 0.147 Extended Metestrus Overall 1 Extended Metestrus 2.5 W/kg vs. Sham Controls 1 Extended Metestrus 5 W/kg vs. Sham Controls 1 Extended Metestrus 10 W/kg vs. Sham Controls 1 Extended Proestrus Overall 1 Extended Proestrus 2.5 W/kg vs. Sham Controls 1 Extended Proestrus 5 W/kg vs. Sham Controls 1 Extended Proestrus 10 W/kg vs. Sham Controls 1 Skipped Estrus Overall 1 Skipped Estrus 2.5 W/kg vs. Sham Controls 1 Skipped Estrus 5 W/kg vs. Sham Controls 1 Skipped Estrus 10 W/kg vs. Sham Controls 1 Skipped Diestrus Overall 1 Skipped Diestrus 2.5 W/kg vs. Sham Controls 1 Skipped Diestrus 5 W/kg vs. Sham Controls 1 Skipped Diestrus 10 W/kg vs. Sham Controls 1 a N means that the treated group had a lower probability of transitioning to the relevant abnormal state (extended estrus, extended diestrus, extended metestrus, extended proestrus, skipped estrus, or skipped diestrus) than did the sham control group. GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 H-5 Peer Review Draft NOT FOR ATTRIBUTION TABLE H4 Summary of Reproductive Tissue Evaluations for Male Mice at the 14-Week Interim Evaluation in the 2-Year CDMA-Modulated Cell Phone RFR Studya Sham Control 2.5 W/kg 5 W/kg 10 W/kg n 10 10 10 10 Weights (g) Necropsy body wt 34.8 ± 0.8 35.5 ± 0.4 33.2 ± 0.7 36.2 ± 0.7 L. Cauda epididymis 0.020 ± 0.001 0.021 ± 0.001 0.020 ± 0.000 0.021 ± 0.000 L. Epididymis 0.048 ± 0.002 0.051 ± 0.002 0.047 ± 0.001 0.051 ± 0.003 L. Testis 0.104 ± 0.002 0.106 ± 0.005 0.105 ± 0.001 0.109 ± 0.002 Spermatid measurements Spermatid heads (106/testis) 21.9 ± 1.9 21.2 ± 1.9 23.4 ± 1.6 22.5 ± 1.8 Spermatid heads (103/mg testis) 210.6 ± 17.0 196.6 ± 11.1 222.8 ± 15.0 205.4 ± 14.6 Epididymal spermatozoal measurements Sperm motility (%) 73.5 ± 5.7 66.3 ± 6.7 67.5 ± 5.9 68.1 ± 8.3 Sperm (106 /cauda epididymis) 24.2 ± 4.7 18.5 ± 4.8 13.0 ± 2.1 18.4 ± 1.5 Sperm (103 /mg cauda epididymis) 1,254.1 ± 258.5 851.4 ± 181.3 674.6 ± 118.8 892.2 ± 69.2 a Data are presented as mean ± standard error. Differences from the sham control group are not significant by Williams’ or Dunnett’s test (body and tissue weights) or Dunn’s test (spermatid and epididymal spermatozoal measurements). TABLE H5 Estrous Cycle Characterization for Female Mice at the 14-Week Interim Evaluation in the 2-Year CDMA-Modulated Cell Phone RFR Studya Sham Control 2.5 W/kg 5 W/kg 10 W/kg Number weighed at necropsy 10 10 10 10 Necropsy body wt (g) 24.4 ± 0.4 25.5 ± 0.5 25.7 ± 0.7 24.5 ± 0.3 Proportion of regular cycling femalesb 10/10 10/10 10/10 10/10 Estrous cycle length (days) 4.0 ± 0.05 4.8 ± 0.71 4.0 ± 0.07 4.0 ± 0.00 Estrous stages (% of cycle) Diestrus 33.8 34.8 42.0 29.9 Proestrus 0.6 1.3 0.6 1.9 Estrus 51.0 47.5 47.8 49.0 Metestrus 14.6 15.2 8.9 19.1 Uncertain diagnoses 0.0 1.3 0.6 0.0 a Necropsy body weights and estrous cycle length data are presented as mean ± standard error. Differences from the sham control group are not significant by Jonckheere’s, Williams’, or Dunnett’s test (body weight) or Jonckheere’s, Shirley’s, or Dunn’s test (estrous cycle length). Tests for equality of transition probability matrices among all groups and between the sham control group and each exposed group indicated exposed females did not have extended estrus or diestrus. b Number of females with a regular cycle/number of females cycling H-6 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft Dose (W/kg) 0 E E D E E D D E E D D E E M D E 0 E M D E D D D E E M D E E D D 0 E M D E E D E E E D D E E E D E 0 E M D E E D D E E D D E E M D E 0 E E M D E E M D E E M D E E M D 0 E E M D E E M D E E M D E E M 0 E E M D E E D D E E M D E E M D 0 E E M D E E D D E E M D E E M 0 E D D P E D D E E D D E E M D E 0 D E E D D E E D D E E M D E E M 2.5 E M D E E E M D E E E M D E E E 2.5 E D D E E M D E E M D E E M D E 2.5 E D D E E D D E E M D E M E D E 2.5 E E M D E E I D E E D D E E M D 2.5 E E D D E E M D E E D D E E M D 2.5 E M D P E D E E D D D E E D D E 2.5 D E E M D E E E D E E M D E E M 2.5 M D E E D D E E M D E E M D E 2.5 D D E E M D E E E M D E E E M 2.5 D P E M D D D D D D D I D E M D 5 E M D E E D D E E D D E E D D D 5 E D D E E D D E E D D E E D D E 5 E D D E E E D D E E D D D D I E 5 E E E M D E E E D E E D D E E M 5 E E E D D E E M D E E M D E E 5 E E D D P E D D E E D D E E M D 5 D E E M D E E D D E E M D E E 5 D E E M D E E D D E E M D D D D 5 D D E E M D E E M D E E D D E E 5 D D D D D E E D D E M D E E M 10 E M D E E M D E E M D E E M D E 10 E E M D E E M D E E M D E E M D 10 E E D D E E M D E E M D E E M 10 E E D D E E D D E E M D E E M 10 E D D P E M D E E M D E E M D E 10 D E E M D E E M D E E M D E E M 10 M D E E M D E E M D E E D D E E 10 M D E E D D E E M D E E M D E E 10 M D E E D D E E D D E E M D E E 10 D P E M D P E D D E E M D E E FIGURE H2 Vaginal Cytology Plots for Female Mice at the 14-Week Interim Evaluation in the 2-Year CDMA-Modulated Cell Phone RFR Study I = Insufficient number of cells to determine stage; D = diestrus, P = proestrus, E = estrus, M = metestrus GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 H-7 Peer Review Draft NOT FOR ATTRIBUTION TABLE H6 Results of Vaginal Cytology Study Using the Transition Matrix Approach in Female Mice at the 14-Week Interim Evaluation in the 2-Year CDMA-Modulated Cell Phone RFR Study Stage Comparison P Value Trenda Overall Tests Overall <0.001 Overall Tests 2.5 W/kg vs. Sham Controls <0.001 Overall Tests 5 W/kg vs. Sham Controls 0.003 Overall Tests 10 W/kg vs. Sham Controls 0.209 N Extended Estrus Overall 0.042 Extended Estrus 2.5 W/kg vs. Sham Controls 0.012 Extended Estrus 5 W/kg vs. Sham Controls 0.333 Extended Estrus 10 W/kg vs. Sham Controls 0.358 N Extended Diestrus Overall 0.006 Extended Diestrus 2.5 W/kg vs. Sham Controls 0.113 Extended Diestrus 5 W/kg vs. Sham Controls 0.002 Extended Diestrus 10 W/kg vs. Sham Controls 0.602 N Extended Metestrus Overall 1 Extended Metestrus 2.5 W/kg vs. Sham Controls 1 Extended Metestrus 5 W/kg vs. Sham Controls 1 Extended Metestrus 10 W/kg vs. Sham Controls 1 Extended Proestrus Overall 1 Extended Proestrus 2.5 W/kg vs. Sham Controls 1 Extended Proestrus 5 W/kg vs. Sham Controls 1 Extended Proestrus 10 W/kg vs. Sham Controls 1 Skipped Estrus Overall 1 Skipped Estrus 2.5 W/kg vs. Sham Controls 1 Skipped Estrus 5 W/kg vs. Sham Controls 1 Skipped Estrus 10 W/kg vs. Sham Controls 1 Skipped Diestrus Overall 1 Skipped Diestrus 2.5 W/kg vs. Sham Controls 0.934 Skipped Diestrus 5 W/kg vs. Sham Controls 1 Skipped Diestrus 10 W/kg vs. Sham Controls 1 Summary of Significant Groups Overall Tests 2.5 W/kg vs. Sham Controls <0.001 Overall Tests 5 W/kg vs. Sham Controls 0.003 Extended Estrus 2.5 W/kg vs. Sham Controls 0.012 Extended Diestrus 5 W/kg vs. Sham Controls 0.002 a N means that the treated group had a lower probability of transitioning to the relevant abnormal state (extended estrus, extended diestrus, extended metestrus, extended proestrus, skipped estrus, or skipped diestrus) than did the sham control group. H-8 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft I-1 Peer Review Draft NOT FOR ATTRIBUTION APPENDIX I GSM- AND CDMA-MODULATED CELL PHONE RFR EXPOSURE DATA OVERVIEW ................................................................................................................................................................. I-2 TABLE I1 Summary of GSM-Modulated Cell Phone RFR Exposure Data – SAR.........................................I-3 TABLE I2 Summary of GSM-Modulated Cell Phone RFR Exposure Data – Chamber Field .......................I-7 TABLE I3 Summary of GSM-Modulated Cell Phone RFR Exposure Data – E-Field ..................................I-11 TABLE I4 Summary of GSM-Modulated Cell Phone RFR Exposure Data – H-Field..................................I-15 TABLE I5 Summary of CDMA-Modulated Cell Phone RFR Exposure Data – SAR....................................I-19 TABLE I6 Summary of CDMA-Modulated Cell Phone RFR Exposure Data – Chamber Field..................I-23 TABLE I7 Summary of CDMA-Modulated Cell Phone RFR Exposure Data – E-Field...............................I-27 TABLE I8 Summary of CDMA-Modulated Cell Phone RFR Exposure Data – H-Field...............................I-31 I-2 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft GSM- AND CDMA-MODULATED CELL PHONE RFR EXPOSURE DATA OVERVIEW Exposure data include SAR (W/kg) (Tables I1 and I5), chamber field strength (V/m) (Tables I2 and I6), E- and H-field measurements (V/m) (Tables I3, I4, I7, and I8). For the medium and high dose GSM chambers, where a second E-field probe was used, the H-field measurements were converted from E-field measurements (E-field divided by 377). Fields were measured continuously throughout the study and measurements were automatically recorded approximately every 20 seconds. For every 20 second interval, the SAR was calculated based on the average H- and/or E-field data. The data presented for each exposure parameter include the mean and standard deviation [expressed in decibels (dB), W/kg, or V/m]; the total number of measurements recorded during the identified period of exposure (>44,000 calculated SAR per month and more than 1.1 million over the course of the 2-year study); the lowest (min) and highest (max) measurement recorded during the given exposure period; the number of measurements that were within the acceptable range; and the ratio of all measurements within range. The data reported for SAR also include the range of animal body weights (g) over the indicated time period of exposure, as well as the selected target SAR for each group. The data reported for field strengths (chamber, E-field, and H-field) include the target range of the field required to maintain appropriate SAR exposures. The minimum and maximum exposure values reported represent a single recorded measurement over the 2-year exposure period. The SAR and chamber-field in the sham and exposure chambers were within the target ranges (defined as ± 2 dB) for >99.85% of recorded measurements over the course of the 2-year study; ≥99.70% of E-field and H-field exposures in the sham and exposure chambers were within the target ranges for all but one chamber (97.35% within range). The dB is a mathematical transformation of a number or numerical ratio using base 10 logarithms. Multiplication of ratios is transformed into addition of dBs; raising a number to a power is transformed into multiplication of dBs. In general, dB(power) = 10 × log(R), and dB(field) = 20 × log(R). The formulas differ by a factor of two because power or SAR varies as the square of the fields. For SAR (in watts/kg), the decibel formula is calculated as: SAR(dB) = 10 × log(SARM/SART) where SARM is the measured value and SART is the target value, and –2 dB = 10 × log(SARL/SART), where SARL (low) = SART × 10–0.2 +2 dB = 10 × log(SARH/SART), where SARH (high) = SART × 100.2 On this basis, the ± 2 dB range specified by the NTP translates to the following ranges for each SAR used in the 2-year study: Target SAR (W/kg) Acceptable SAR Range (W/kg; ± 2 dB) 2.5 1.58 to 3.96 5 3.15 to 7.92 10 6.31 to 15.85 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 I-3 Peer Review Draft NOT FOR ATTRIBUTION TABLE I1 Summary of GSM-Modulated Cell Phone RFR Exposure Data – SARa Weight Range Target Mean Stdev Min Max In Range/ Chamber [g] [W/kg] [W/kg] [dB]/[W/kg] [W/kg] [W/kg] Total Ratio June 18 to 30, 2012 Ch11 Mouse GSM High 18.9 to 20.2 10.00 10.08 0.23/0.05 3.944 23.576 19472/19475 1.000 Ch12 Mouse GSM Med 18.9 to 20.2 5.00 5.04 0.21/0.05 2.105 11.918 19472/19475 1.000 Ch14 Mouse GSM Low 18.8 to 20.2 2.50 2.51 0.20/0.05 1.948 3.175 19475/19475 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 19475/19475 1.000 July 1 to 31, 2012 Ch11 Mouse GSM High 20.2 to 24.1 10.00 10.01 0.23/0.05 7.430 13.279 48731/48731 1.000 Ch12 Mouse GSM Med 20.2 to 24.6 5.00 5.01 0.21/0.05 3.349 7.170 48731/48731 1.000 Ch14 Mouse GSM Low 20.2 to 24.5 2.50 2.50 0.18/0.04 2.103 3.135 48731/48731 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 48731/48731 1.000 August 1 to 31, 2012 Ch11 Mouse GSM High 24.1 to 27.5 10.00 10.02 0.20/0.05 6.893 13.910 47488/47488 1.000 Ch12 Mouse GSM Med 24.6 to 27.9 5.00 5.03 0.20/0.05 3.911 6.803 47488/47488 1.000 Ch14 Mouse GSM Low 24.5 to 27.2 2.50 2.50 0.18/0.04 1.900 3.441 47488/47488 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 47488/47488 1.000 September 1 to 30, 2012 Ch11 Mouse GSM High 27.5 to 29.3 10.00 10.01 0.21/0.05 5.187 12.693 47186/47187 1.000 Ch12 Mouse GSM Med 27.9 to 30.0 5.00 5.01 0.19/0.04 2.558 6.280 47184/47185 1.000 Ch14 Mouse GSM Low 27.2 to 29.2 2.50 2.51 0.18/0.04 1.444 3.129 47184/47185 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 47185/47185 1.000 October 1 to 31, 2012 Ch11 Mouse GSM High 29.3 to 32.9 10.00 10.02 0.19/0.05 3.290 12.620 48801/48802 1.000 Ch12 Mouse GSM Med 30.0 to 33.8 5.00 5.02 0.18/0.04 3.828 6.511 48801/48801 1.000 Ch14 Mouse GSM Low 29.2 to 32.7 2.50 2.51 0.17/0.04 2.017 3.080 48801/48801 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 48801/48801 1.000 November 1 to 30, 2012 Ch11 Mouse GSM High 32.9 to 36.6 10.00 10.03 0.19/0.04 7.649 13.824 47314/47314 1.000 Ch12 Mouse GSM Med 33.8 to 36.4 5.00 5.02 0.17/0.04 3.724 6.537 47314/47314 1.000 Ch14 Mouse GSM Low 32.7 to 35.8 2.50 2.51 0.17/0.04 2.054 3.110 47314/47314 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 47314/47314 1.000 December 1 to 31, 2012 Ch11 Mouse GSM High 36.6 to 39.1 10.00 10.07 0.20/0.05 7.992 12.863 48750/48750 1.000 Ch12 Mouse GSM Med 36.4 to 39.2 5.00 5.04 0.18/0.04 4.145 6.028 48748/48748 1.000 Ch14 Mouse GSM Low 35.8 to 38.1 2.50 2.52 0.17/0.04 2.139 3.109 48748/48748 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 48748/48748 1.000 a Ch=chamber (e.g., Ch11=Chamber 11) I-4 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE I1 Summary of GSM-Modulated Cell Phone RFR Exposure Data – SAR Weight Range Target Mean Stdev Min Max In Range/ Chamber [g] [W/kg] [W/kg] [dB]/[W/kg] [W/kg] [W/kg] Total Ratio January 1 to 31, 2013 Ch11 Mouse GSM High 39.1 to 41.1 10.00 9.78 0.30/0.07 7.230 13.516 48689/48689 1.000 Ch12 Mouse GSM Med 39.2 to 41.6 5.00 5.02 0.20/0.05 3.121 7.619 48681/48682 1.000 Ch14 Mouse GSM Low 38.1 to 40.6 2.50 2.51 0.17/0.04 2.037 2.987 48682/48682 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 48682/48682 1.000 February 1 to 28, 2013 Ch11 Mouse GSM High 41.1 to 42.9 10.00 8.23 0.22/0.05 6.187 10.364 44057/44058 1.000 Ch12 Mouse GSM Med 41.6 to 43.5 5.00 5.02 0.17/0.04 3.872 5.967 44058/44058 1.000 Ch14 Mouse GSM Low 40.6 to 42.2 2.50 2.52 0.17/0.04 1.851 3.048 44058/44058 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 44058/44058 1.000 March 1 to 31, 2013 Ch11 Mouse GSM High 42.9 to 44.4 10.00 8.25 0.24/0.06 6.753 10.627 48892/48892 1.000 Ch12 Mouse GSM Med 43.5 to 44.7 5.00 5.04 0.17/0.04 4.276 5.871 48892/48892 1.000 Ch14 Mouse GSM Low 42.2 to 43.4 2.50 2.51 0.17/0.04 2.143 2.943 48892/48892 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 48892/48892 1.000 April 1 to 30, 2013 Ch11 Mouse GSM High 44.4 to 46.8 10.00 7.95 0.20/0.05 6.370 9.872 48130/48130 1.000 Ch12 Mouse GSM Med 44.7 to 47.3 5.00 5.02 0.17/0.04 4.113 5.862 48130/48130 1.000 Ch14 Mouse GSM Low 43.4 to 46.0 2.50 2.52 0.16/0.04 2.214 2.995 48130/48130 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 48130/48130 1.000 May 1 to 31, 2013 Ch11 Mouse GSM High 46.8 to 47.9 10.00 7.94 0.19/0.04 5.057 9.940 48509/48510 1.000 Ch12 Mouse GSM Med 47.3 to 48.7 5.00 5.01 0.17/0.04 3.264 7.176 48510/48510 1.000 Ch14 Mouse GSM Low 46.0 to 47.5 2.50 2.51 0.17/0.04 1.809 2.957 48510/48510 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 48510/48510 1.000 June 1 to 30, 2013 Ch11 Mouse GSM High 47.9 to 49.2 10.00 7.44 0.17/0.04 6.134 9.224 47246/47248 1.000 Ch12 Mouse GSM Med 48.7 to 49.9 5.00 5.01 0.17/0.04 4.185 5.911 47248/47248 1.000 Ch14 Mouse GSM Low 47.5 to 49.0 2.50 2.50 0.16/0.04 1.964 2.923 47248/47248 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 47248/47248 1.000 July 1 to 31, 2013 Ch11 Mouse GSM High 49.2 to 50.5 10.00 8.02 0.26/0.06 5.376 10.141 49496/49573 0.998 Ch12 Mouse GSM Med 49.9 to 51.5 5.00 5.01 0.17/0.04 3.448 5.910 49573/49573 1.000 Ch14 Mouse GSM Low 49.0 to 50.2 2.50 2.51 0.17/0.04 1.876 2.915 49573/49573 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 49573/49573 1.000 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 I-5 Peer Review Draft NOT FOR ATTRIBUTION TABLE I1 Summary of GSM-Modulated Cell Phone RFR Exposure Data – SAR Weight Range Target Mean Stdev Min Max In Range/ Chamber [g] [W/kg] [W/kg] [dB]/[W/kg] [W/kg] [W/kg] Total Ratio August 1 to 31, 2013 Ch11 Mouse GSM High 50.5 to 51.3 10.00 8.33 0.22/0.05 6.666 10.172 50850/50850 1.000 Ch12 Mouse GSM Med 51.5 to 52.5 5.00 4.99 0.18/0.04 4.182 6.536 50850/50850 1.000 Ch14 Mouse GSM Low 50.2 to 51.3 2.50 2.50 0.17/0.04 2.065 3.317 50850/50850 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 50850/50850 1.000 September 1 to 30, 2013 Ch11 Mouse GSM High 51.3 to 52.0 10.95 9.88 0.40/0.10 3.473 14.080 46959/46961 1.000 Ch12 Mouse GSM Med 52.5 to 53.2 5.00 5.01 0.18/0.04 4.292 5.988 46960/46960 1.000 Ch14 Mouse GSM Low 51.3 to 52.2 2.50 2.50 0.17/0.04 1.329 2.996 46956/46960 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 46960/46960 1.000 October 1 to 31, 2013 Ch11 Mouse GSM High 52.0 to 53.3 10.95 10.83 0.22/0.05 6.969 14.792 50408/50408 1.000 Ch12 Mouse GSM Med 53.2 to 54.0 5.00 5.01 0.19/0.04 3.215 5.974 50408/50408 1.000 Ch14 Mouse GSM Low 52.2 to 53.0 2.50 2.50 0.16/0.04 1.669 3.009 50408/50408 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 50408/50408 1.000 November 1 to 30, 2013 Ch11 Mouse GSM High 52.4 to 53.3 10.95 9.54 0.35/0.08 5.677 13.090 46609/46613 1.000 Ch12 Mouse GSM Med 53.1 to 54.0 5.00 4.96 0.24/0.06 2.923 7.086 46612/46613 1.000 Ch14 Mouse GSM Low 52.4 to 53.0 2.50 2.50 0.19/0.05 1.629 2.955 46613/46613 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 46613/46613 1.000 December 1 to 31, 2013 Ch11 Mouse GSM High 51.4 to 52.4 10.95 10.22 0.36/0.09 7.156 13.073 48423/48423 1.000 Ch12 Mouse GSM Med 51.9 to 53.1 5.00 4.96 0.21/0.05 3.618 7.513 48423/48423 1.000 Ch14 Mouse GSM Low 51.1 to 52.4 2.50 2.50 0.18/0.04 1.475 4.060 48421/48423 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 48423/48423 1.000 January 1 to 31, 2014 Ch11 Mouse GSM High 51.4 to 52.1 10.95 10.08 0.27/0.06 6.308 13.144 48774/48775 1.000 Ch12 Mouse GSM Med 51.9 to 52.7 5.00 5.00 0.20/0.05 3.593 6.330 48775/48775 1.000 Ch14 Mouse GSM Low 51.1 to 51.6 2.50 2.50 0.18/0.04 0.472 3.843 48772/48775 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 48775/48775 1.000 February 1 to 28, 2014 Ch11 Mouse GSM High 52.1 to 53.2 10.95 10.92 0.24/0.06 8.258 15.024 44092/44092 1.000 Ch12 Mouse GSM Med 52.7 to 53.6 5.00 4.59 0.41/0.10 2.273 6.443 43990/44092 0.998 Ch14 Mouse GSM Low 51.6 to 53.1 2.50 2.50 0.18/0.04 1.622 3.807 44092/44092 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 44092/44092 1.000 I-6 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE I1 Summary of GSM-Modulated Cell Phone RFR Exposure Data – SAR Weight Range Target Mean Stdev Min Max In Range/ Chamber [g] [W/kg] [W/kg] [dB]/[W/kg] [W/kg] [W/kg] Total Ratio March 1 to 31, 2014 Ch11 Mouse GSM High 52.8 to 53.8 10.95 10.27 0.43/0.10 6.995 15.483 48571/48571 1.000 Ch12 Mouse GSM Med 53.3 to 53.8 5.00 4.56 0.60/0.15 2.706 6.677 47927/48571 0.987 Ch14 Mouse GSM Low 52.8 to 53.3 2.50 2.51 0.16/0.04 1.877 3.110 48571/48571 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 48571/48571 1.000 April 1 to 30, 2014 Ch11 Mouse GSM High 51.5 to 52.3 10.95 10.73 0.41/0.10 7.050 14.898 47274/47274 1.000 Ch12 Mouse GSM Med 53.0 to 53.4 5.00 4.92 0.66/0.16 2.581 8.007 46546/47274 0.985 Ch14 Mouse GSM Low 51.9 to 52.3 2.50 2.50 0.15/0.03 1.868 2.893 47274/47274 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 47274/47274 1.000 May 1 to 31, 2014 Ch11 Mouse GSM High 50.5 to 51.5 10.95 10.95 0.22/0.05 6.826 14.016 48620/48622 1.000 Ch12 Mouse GSM Med 51.3 to 53.0 5.00 5.00 0.22/0.05 2.622 7.487 48550/48622 0.999 Ch14 Mouse GSM Low 51.2 to 51.9 2.50 2.50 0.15/0.03 2.188 2.921 48622/48622 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 48622/48622 1.000 June 1 to 30, 2014 Ch11 Mouse GSM High 49.4 to 50.5 10.95 10.97 0.20/0.05 8.188 13.942 47144/47144 1.000 Ch12 Mouse GSM Med 50.8 to 51.3 5.00 5.01 0.16/0.04 3.005 5.830 47142/47144 1.000 Ch14 Mouse GSM Low 50.2 to 51.2 2.50 2.51 0.15/0.03 2.153 2.870 47144/47144 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 47144/47144 1.000 July 1 to 9, 2014 Ch11 Mouse GSM High 49.4 to 49.4 10.95 11.08 0.19/0.04 8.839 13.746 12532/12532 1.000 Ch12 Mouse GSM Med 50.8 to 50.8 5.00 5.02 0.15/0.04 4.488 5.844 12532/12532 1.000 Ch14 Mouse GSM Low 50.2 to 50.2 2.50 2.51 0.17/0.04 1.995 3.111 12532/12532 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 12532/12532 1.000 June 18, 2012, to July 9, 2014 Ch11 Mouse GSM High 18.9 to 53.8 10.95 9.56 0.44/0.11 3.290 23.576 1136126/1136221 1.000 Ch12 Mouse GSM Med 18.9 to 54.0 5.00 4.97 0.29/0.07 2.105 11.918 1134656/1136208 0.999 Ch14 Mouse GSM Low 18.8 to 53.3 2.50 2.51 0.17/0.04 0.472 4.060 1136198/1136208 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 1136208/1136208 1.000 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 I-7 Peer Review Draft NOT FOR ATTRIBUTION TABLE I2 Summary of GSM-Modulated Cell Phone RFR Exposure Data – Chamber Fielda Target Range Mean Stdev Min Max In Range/ Chamber [V/m] [V/m] [dB]/[V/m] [V/m] [V/m] Total Ratio June 18 to 30, 2012 Ch11 Mouse GSM High 194.10 to 199.60 197.33 0.23/5.27 121.76 297.71 38944/38950 1.000 Ch12 Mouse GSM Med 137.20 to 141.20 139.51 0.21/3.45 88.97 211.67 38944/38950 1.000 Ch14 Mouse GSM Low 97.00 to 99.80 98.42 0.20/2.26 88.09 109.25 38950/38950 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 38950/38950 1.000 July 1 to 31, 2012 Ch11 Mouse GSM High 199.60 to 212.30 205.98 0.23/5.60 180.13 237.61 97462/97462 1.000 Ch12 Mouse GSM Med 141.20 to 150.10 145.84 0.21/3.55 119.12 174.30 97462/97462 1.000 Ch14 Mouse GSM Low 99.80 to 106.10 103.40 0.18/2.22 92.84 116.92 97462/97462 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 97462/97462 1.000 August 1 to 31, 2012 Ch11 Mouse GSM High 212.30 to 222.20 216.19 0.20/5.04 181.61 257.98 94976/94976 1.000 Ch12 Mouse GSM Med 150.10 to 157.10 154.16 0.20/3.67 136.80 180.42 94976/94976 1.000 Ch14 Mouse GSM Low 106.10 to 111.10 108.48 0.18/2.26 95.61 130.19 94976/94976 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 94976/94976 1.000 September 1 to 30, 2012 Ch11 Mouse GSM High 222.20 to 228.20 226.30 0.21/5.48 162.27 251.45 94372/94374 1.000 Ch12 Mouse GSM Med 157.10 to 161.40 160.65 0.19/3.49 115.42 179.26 94368/94370 1.000 Ch14 Mouse GSM Low 111.10 to 114.10 112.89 0.18/2.35 85.61 126.49 94368/94370 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 94370/94370 1.000 October 1 to 31, 2012 Ch11 Mouse GSM High 228.20 to 235.60 232.23 0.20/5.31 135.19 264.78 97602/97602 1.000 Ch12 Mouse GSM Med 161.40 to 168.00 165.17 0.18/3.51 141.20 191.80 97602/97602 1.000 Ch14 Mouse GSM Low 114.10 to 117.80 116.22 0.17/2.29 102.50 129.10 97602/97602 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 97602/97602 1.000 November 1 to 30, 2012 Ch11 Mouse GSM High 235.60 to 242.70 240.08 0.19/5.34 212.13 285.16 94628/94628 1.000 Ch12 Mouse GSM Med 168.00 to 171.70 170.49 0.17/3.37 145.05 192.18 94628/94628 1.000 Ch14 Mouse GSM Low 117.80 to 120.60 119.65 0.17/2.35 108.08 134.46 94628/94628 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 94628/94628 1.000 December 1 to 31, 2012 Ch11 Mouse GSM High 242.70 to 247.20 246.27 0.20/5.79 220.75 280.06 97500/97500 1.000 Ch12 Mouse GSM Med 171.70 to 174.80 174.25 0.18/3.56 158.98 191.03 97496/97496 1.000 Ch14 Mouse GSM Low 120.60 to 122.90 122.40 0.17/2.38 111.52 136.85 97496/97496 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 97496/97496 1.000 a Ch=chamber (e.g., Ch11=Chamber 11) I-8 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE I2 Summary of GSM-Modulated Cell Phone RFR Exposure Data – Chamber Field Target Range Mean Stdev Min Max In Range/ Chamber [V/m] [V/m] [dB]/[V/m] [V/m] [V/m] Total Ratio January 1 to 31, 2013 Ch11 Mouse GSM High 247.20 to 249.80 246.34 0.31/8.90 212.57 290.65 97378/97378 1.000 Ch12 Mouse GSM Med 174.80 to 176.70 176.61 0.21/4.30 139.67 218.22 97362/97364 1.000 Ch14 Mouse GSM Low 122.90 to 124.30 124.22 0.17/2.39 112.14 135.78 97364/97364 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 97364/97364 1.000 February 1 to 28, 2013 Ch11 Mouse GSM High 249.80 to 251.10 227.29 0.25/6.60 197.26 254.51 88114/88116 1.000 Ch12 Mouse GSM Med 176.70 to 178.50 178.60 0.17/3.60 157.05 194.95 88116/88116 1.000 Ch14 Mouse GSM Low 124.30 to 125.60 125.67 0.17/2.43 107.89 138.45 88116/88116 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 88116/88116 1.000 March 1 to 31, 2013 Ch11 Mouse GSM High 251.10 to 253.60 229.49 0.26/7.11 207.98 261.00 97784/97784 1.000 Ch12 Mouse GSM Med 178.50 to 179.30 179.57 0.17/3.62 165.02 193.99 97784/97784 1.000 Ch14 Mouse GSM Low 125.60 to 126.20 126.39 0.17/2.55 116.82 136.92 97784/97784 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 97784/97784 1.000 April 1 to 30, 2013 Ch11 Mouse GSM High 253.60 to 256.00 227.10 0.23/5.99 203.37 253.19 96260/96260 1.000 Ch12 Mouse GSM Med 179.30 to 181.80 180.58 0.18/3.69 163.42 195.38 96260/96260 1.000 Ch14 Mouse GSM Low 126.20 to 127.40 127.12 0.16/2.42 119.14 138.56 96260/96260 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 96260/96260 1.000 May 1 to 31, 2013 Ch11 Mouse GSM High 256.00 to 257.20 227.85 0.21/5.62 181.80 254.88 97018/97020 1.000 Ch12 Mouse GSM Med 181.80 to 182.60 182.15 0.17/3.65 147.02 218.01 97020/97020 1.000 Ch14 Mouse GSM Low 127.40 to 128.60 127.68 0.17/2.51 108.39 138.57 97020/97020 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 97020/97020 1.000 June 1 to 30, 2013 Ch11 Mouse GSM High 257.20 to 259.40 222.18 0.20/5.26 202.90 247.16 94490/94496 1.000 Ch12 Mouse GSM Med 182.60 to 183.40 182.92 0.17/3.62 167.03 198.51 94496/94496 1.000 Ch14 Mouse GSM Low 128.60 to 129.10 128.74 0.16/2.39 114.06 139.13 94496/94496 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 94496/94496 1.000 July 1 to 31, 2013 Ch11 Mouse GSM High 259.40 to 260.60 232.30 0.29/7.92 189.95 261.63 98976/99146 0.998 Ch12 Mouse GSM Med 183.40 to 185.00 183.88 0.17/3.71 152.12 201.19 99146/99146 1.000 Ch14 Mouse GSM Low 129.10 to 130.30 129.63 0.17/2.54 111.83 140.17 99146/99146 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 99146/99146 1.000 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 I-9 Peer Review Draft NOT FOR ATTRIBUTION TABLE I2 Summary of GSM-Modulated Cell Phone RFR Exposure Data – Chamber Field Target Range Mean Stdev Min Max In Range/ Chamber [V/m] [V/m] [dB]/[V/m] [V/m] [V/m] Total Ratio August 1 to 31, 2013 Ch11 Mouse GSM High 260.60 to 261.60 238.28 0.24/6.76 212.95 263.95 101700/101700 1.000 Ch12 Mouse GSM Med 185.00 to 185.80 185.04 0.18/3.97 169.82 211.58 101700/101700 1.000 Ch14 Mouse GSM Low 130.30 to 130.80 130.56 0.17/2.57 118.52 150.21 101700/101700 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 101700/101700 1.000 September 1 to 30, 2013 Ch11 Mouse GSM High 261.60 to 273.80 259.49 0.42/12.99 154.24 310.55 93918/93922 1.000 Ch12 Mouse GSM Med 185.80 to 186.60 186.08 0.19/4.02 172.65 203.93 93920/93920 1.000 Ch14 Mouse GSM Low 130.80 to 131.40 131.14 0.17/2.55 95.42 143.74 93912/93920 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 93920/93920 1.000 October 1 to 31, 2013 Ch11 Mouse GSM High 273.80 to 276.10 273.26 0.23/7.32 219.98 320.51 100816/100816 1.000 Ch12 Mouse GSM Med 186.60 to 186.60 186.50 0.19/4.08 149.42 203.69 100816/100816 1.000 Ch14 Mouse GSM Low 131.40 to 131.40 131.40 0.16/2.42 107.28 144.05 100816/100816 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 100816/100816 1.000 November 1 to 30, 2013 Ch11 Mouse GSM High 275.00 to 276.10 256.54 0.37/11.29 197.87 301.50 93218/93226 1.000 Ch12 Mouse GSM Med 186.60 to 186.60 185.47 0.25/5.34 142.46 221.82 93224/93226 1.000 Ch14 Mouse GSM Low 131.40 to 131.40 131.34 0.20/3.01 106.00 142.76 93226/93226 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 93226/93226 1.000 December 1 to 31, 2013 Ch11 Mouse GSM High 273.80 to 275.00 264.56 0.38/11.98 222.16 299.75 96846/96846 1.000 Ch12 Mouse GSM Med 185.00 to 186.60 184.56 0.21/4.62 157.41 228.42 96846/96846 1.000 Ch14 Mouse GSM Low 130.80 to 131.40 130.98 0.18/2.74 100.51 166.76 96842/96846 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 96846/96846 1.000 January 1 to 31, 2014 Ch11 Mouse GSM High 273.80 to 275.00 263.34 0.29/8.82 208.57 301.08 97548/97550 1.000 Ch12 Mouse GSM Med 185.00 to 185.80 185.51 0.20/4.28 157.42 208.93 97550/97550 1.000 Ch14 Mouse GSM Low 130.80 to 130.80 130.79 0.18/2.80 56.85 162.24 97544/97550 1.000 Ch13 Mouse Sham 000.00 to 000.00 0.00 –/0.00 0.00 0.00 97550/97550 1.000 February 1 to 28, 2014 Ch11 Mouse GSM High 275.00 to 276.10 275.23 0.24/7.74 239.47 323.01 88184/88184 1.000 Ch12 Mouse GSM Med 185.80 to 186.60 178.26 0.45/9.39 125.65 211.52 87980/88184 0.998 Ch14 Mouse GSM Low 130.80 to 131.90 131.73 0.18/2.73 106.14 162.60 88184/88184 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 88184/88184 1.000 I-10 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE I2 Summary of GSM-Modulated Cell Phone RFR Exposure Data – Chamber Field Target Range Mean Stdev Min Max In Range/ Chamber [V/m] [V/m] [dB]/[V/m] [V/m] [V/m] Total Ratio March 1 to 31, 2014 Ch11 Mouse GSM High 275.00 to 276.10 266.21 0.46/14.46 220.40 327.90 97142/97142 1.000 Ch12 Mouse GSM Med 186.60 to 186.60 177.33 0.67/14.20 137.09 215.33 95760/97142 0.986 Ch14 Mouse GSM Low 131.40 to 131.90 131.77 0.16/2.40 114.17 146.97 97142/97142 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 97142/97142 1.000 April 1 to 30, 2014 Ch11 Mouse GSM High 273.80 to 275.00 271.16 0.43/13.88 220.51 319.44 94548/94548 1.000 Ch12 Mouse GSM Med 185.80 to 186.60 184.10 0.70/15.37 133.88 235.80 93074/94548 0.984 Ch14 Mouse GSM Low 130.80 to 131.40 131.27 0.15/2.29 113.50 141.25 94548/94548 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 94548/94548 1.000 May 1 to 31, 2014 Ch11 Mouse GSM High 272.70 to 273.80 273.60 0.23/7.40 216.22 309.84 97240/97244 1.000 Ch12 Mouse GSM Med 185.00 to 185.80 185.60 0.24/5.11 134.48 227.23 97098/97244 0.998 Ch14 Mouse GSM Low 130.80 to 130.80 130.87 0.15/2.24 122.41 141.45 97244/97244 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 97244/97244 1.000 June 1 to 30, 2014 Ch11 Mouse GSM High 271.50 to 272.70 272.64 0.20/6.44 236.01 307.96 94288/94288 1.000 Ch12 Mouse GSM Med 184.20 to 185.00 184.73 0.16/3.49 142.97 199.14 94286/94288 1.000 Ch14 Mouse GSM Low 130.30 to 130.80 130.94 0.15/2.22 121.45 140.21 94288/94288 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 94288/94288 1.000 July 1 to 9, 2014 Ch11 Mouse GSM High 271.50 to 271.50 272.57 0.19/5.96 243.57 303.74 25064/25064 1.000 Ch12 Mouse GSM Med 184.20 to 184.20 184.80 0.15/3.27 174.73 199.39 25064/25064 1.000 Ch14 Mouse GSM Low 130.30 to 130.30 130.69 0.17/2.66 116.49 145.47 25064/25064 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 25064/25064 1.000 June 18, 2012, to July 9, 2014 Ch11 Mouse GSM High 194.10 to 276.10 244.10 0.48/13.78 121.76 327.90 2272234/2272442 1.000 Ch12 Mouse GSM Med 137.20 to 186.60 176.76 0.31/6.35 88.97 235.80 2269198/2272416 0.999 Ch14 Mouse GSM Low 97.00 to 131.90 125.14 0.17/2.48 56.85 166.76 2272396/2272416 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 2272416/2272416 1.000 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 I-11 Peer Review Draft NOT FOR ATTRIBUTION TABLE I3 Summary of GSM-Modulated Cell Phone RFR Exposure Data – E-Fielda Target Range Mean Stdev Min Max In Range/ Chamber [V/m] [V/m] [dB]/[V/m] [V/m] [V/m] Total Ratio June 18 to 30, 2012 Ch11 Mouse GSM High 194.1 to 199.6 220.41 0.36/9.20 134.8 342.3 38908/38950 0.999 Ch12 Mouse GSM Med 137.2 to 141.2 148.22 0.31/5.41 93.1 224.6 38944/38950 1.000 Ch14 Mouse GSM Low 97.0 to 99.8 93.00 0.25/2.72 82.8 106.6 38950/38950 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 38950/38950 1.000 July 1 to 31, 2012 Ch11 Mouse GSM High 199.6 to 212.3 232.54 0.37/10.25 191.3 275.5 97310/97462 0.998 Ch12 Mouse GSM Med 141.2 to 150.1 154.86 0.31/5.70 121.0 190.6 97460/97462 1.000 Ch14 Mouse GSM Low 99.8 to 106.1 96.90 0.23/2.66 85.6 111.1 97462/97462 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 97462/97462 1.000 August 1 to 31, 2012 Ch11 Mouse GSM High 212.3 to 222.2 249.45 0.37/10.92 204.4 315.0 94710/94976 0.997 Ch12 Mouse GSM Med 150.1 to 157.1 164.75 0.31/5.97 144.8 197.2 94968/94976 1.000 Ch14 Mouse GSM Low 106.1 to 111.1 101.69 0.23/2.69 89.1 120.4 94976/94976 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 94976/94976 1.000 September 1 to 30, 2012 Ch11 Mouse GSM High 222.2 to 228.2 267.26 0.37/11.47 193.8 317.6 93216/94374 0.988 Ch12 Mouse GSM Med 157.1 to 161.4 171.56 0.31/6.17 119.3 197.8 94366/94370 1.000 Ch14 Mouse GSM Low 114.1 to 117.8 110.31 0.25/3.25 94.8 125.7 94962/94962 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 94962/94962 1.000 October 1 to 31, 2012 Ch11 Mouse GSM High 228.2 to 235.6 270.30 0.36/11.39 161.2 317.0 97028/97604 0.994 Ch12 Mouse GSM Med 161.4 to 168.0 172.36 0.29/5.83 149.2 200.7 97602/97602 1.000 Ch14 Mouse GSM Low 114.1 to 117.8 110.32 0.25/3.26 94.8 125.7 97602/97602 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 97602/97602 1.000 November 1 to 30, 2012 Ch11 Mouse GSM High 235.6 to 242.7 280.59 0.36/11.92 236.7 351.9 93952/94628 0.993 Ch12 Mouse GSM Med 168.0 to 171.7 175.49 0.26/5.33 150.0 202.3 94628/94628 1.000 Ch14 Mouse GSM Low 117.8 to 120.6 112.89 0.23/3.09 99.2 127.3 94628/94628 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 94628/94628 1.000 December 1 to 31, 2012 Ch11 Mouse GSM High 242.7 to 247.2 291.82 0.38/13.01 253.5 340.0 95756/97500 0.982 Ch12 Mouse GSM Med 171.7 to 174.8 180.56 0.27/5.72 161.5 204.8 97496/97496 1.000 Ch14 Mouse GSM Low 120.6 to 122.9 117.17 0.24/3.25 104.1 133.5 97496/97496 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 97496/97496 1.000 a Ch=chamber (e.g., Ch11=Chamber 11) I-12 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE I3 Summary of GSM-Modulated Cell Phone RFR Exposure Data – E-Field Target Range Mean Stdev Min Max In Range/ Chamber [V/m] [V/m] [dB]/[V/m] [V/m] [V/m] Total Ratio January 1 to 31, 2013 Ch11 Mouse GSM High 247.2 to 249.8 285.35 0.64/21.65 229.0 359.4 96120/97378 0.987 Ch12 Mouse GSM Med 174.8 to 176.7 183.63 0.30/6.49 148.1 233.4 97362/97364 1.000 Ch14 Mouse GSM Low 122.9 to 124.3 119.13 0.24/3.35 104.9 133.0 97364/97364 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 97364/97364 1.000 February 1 to 28, 2013 Ch11 Mouse GSM High 249.8 to 251.1 245.59 0.41/11.75 208.2 292.5 88116/88116 1.000 Ch12 Mouse GSM Med 176.7 to 178.5 187.59 0.28/6.15 161.8 212.4 88116/88116 1.000 Ch14 Mouse GSM Low 124.3 to 125.6 119.66 0.24/3.39 99.0 135.0 88114/88116 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 88116/88116 1.000 March 1 to 31, 2013 Ch11 Mouse GSM High 251.1 to 253.6 248.20 0.40/11.68 213.4 298.3 97784/97784 1.000 Ch12 Mouse GSM Med 178.5 to 179.3 187.29 0.30/6.68 163.4 215.1 97784/97784 1.000 Ch14 Mouse GSM Low 125.6 to 126.2 121.50 0.25/3.56 109.2 138.8 97784/97784 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 97784/97784 1.000 April 1 to 30, 2013 Ch11 Mouse GSM High 253.6 to 256.0 245.75 0.37/10.67 206.0 283.6 96260/96260 1.000 Ch12 Mouse GSM Med 179.3 to 181.8 188.33 0.28/6.14 169.2 215.0 96260/96260 1.000 Ch14 Mouse GSM Low 126.2 to 127.4 119.94 0.24/3.42 106.9 134.6 96260/96260 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 96260/96260 1.000 May 1 to 31, 2013 Ch11 Mouse GSM High 256.0 to 257.2 245.46 0.34/9.92 192.9 297.6 97018/97020 1.000 Ch12 Mouse GSM Med 181.8 to 182.6 184.92 0.36/7.72 154.7 219.8 97020/97020 1.000 Ch14 Mouse GSM Low 127.4 to 128.6 123.25 0.25/3.53 101.9 137.4 97020/97020 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 97020/97020 1.000 June 1 to 30, 2013 Ch11 Mouse GSM High 257.2 to 259.4 238.55 0.31/8.53 208.8 277.6 94496/94496 1.000 Ch12 Mouse GSM Med 182.6 to 183.4 180.20 0.27/5.60 160.4 204.7 94496/94496 1.000 Ch14 Mouse GSM Low 128.6 to 129.1 122.13 0.22/3.17 106.8 134.2 94496/94496 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 94496/94496 1.000 July 1 to 31, 2013 Ch11 Mouse GSM High 259.4 to 260.6 252.77 0.48/14.26 209.6 302.8 99146/99146 1.000 Ch12 Mouse GSM Med 183.4 to 185.0 180.18 0.26/5.54 149.9 202.6 99146/99146 1.000 Ch14 Mouse GSM Low 129.1 to 130.3 122.67 0.24/3.49 99.9 137.4 99144/99146 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 99146/99146 1.000 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 I-13 Peer Review Draft NOT FOR ATTRIBUTION TABLE I3 Summary of GSM-Modulated Cell Phone RFR Exposure Data – E-Field Target Range Mean Stdev Min Max In Range/ Chamber [V/m] [V/m] [dB]/[V/m] [V/m] [V/m] Total Ratio August 1 to 31, 2013 Ch11 Mouse GSM High 260.6 to 261.6 238.13 0.36/10.20 205.2 287.5 101698/101700 1.000 Ch12 Mouse GSM Med 185.0 to 185.8 180.96 0.29/6.22 160.7 210.2 101700/101700 1.000 Ch14 Mouse GSM Low 130.3 to 130.8 124.66 0.25/3.62 109.9 141.5 101700/101700 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 101700/101700 1.000 September 1 to 30, 2013 Ch11 Mouse GSM High 261.6 to 273.8 251.71 0.43/12.83 161.3 311.1 93890/93922 1.000 Ch12 Mouse GSM Med 185.8 to 186.6 181.55 0.28/5.84 159.1 205.9 93920/93920 1.000 Ch14 Mouse GSM Low 130.8 to 131.4 124.86 0.25/3.59 89.3 140.0 93912/93920 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 93920/93920 1.000 October 1 to 31, 2013 Ch11 Mouse GSM High 273.8 to 276.1 264.68 0.29/9.12 209.0 306.5 100814/100816 1.000 Ch12 Mouse GSM Med 186.6 to 186.6 182.15 0.28/5.91 145.4 205.6 100814/100816 1.000 Ch14 Mouse GSM Low 131.4 to 131.4 123.98 0.24/3.55 105.9 138.5 100816/100816 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 100816/100816 1.000 November 1 to 30, 2013 Ch11 Mouse GSM High 275.0 to 276.1 257.28 0.39/11.82 206.1 315.3 93220/93226 1.000 Ch12 Mouse GSM Med 186.6 to 186.6 184.13 0.34/7.34 135.2 228.1 93216/93226 1.000 Ch14 Mouse GSM Low 131.4 to 131.4 126.40 0.28/4.12 100.9 141.5 93198/93226 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 93226/93226 1.000 December 1 to 31, 2013 Ch11 Mouse GSM High 273.8 to 275.0 265.70 0.39/12.26 214.7 308.3 96844/96846 1.000 Ch12 Mouse GSM Med 185.0 to 186.6 179.76 0.29/6.11 155.1 224.0 96846/96846 1.000 Ch14 Mouse GSM Low 130.8 to 131.4 122.89 0.25/3.62 95.3 152.2 96842/96846 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 96846/96846 1.000 January 1 to 31, 2014 Ch11 Mouse GSM High 273.8 to 275.0 266.12 0.43/13.48 208.2 324.0 97548/97550 1.000 Ch12 Mouse GSM Med 185.0 to 185.8 180.59 0.27/5.78 156.4 207.5 97550/97550 1.000 Ch14 Mouse GSM Low 130.8 to 130.8 123.43 0.25/3.65 54.4 157.5 97538/97550 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 97550/97550 1.000 February 1 to 28, 2014 Ch11 Mouse GSM High 275.0 to 276.1 285.13 0.43/14.31 235.0 380.5 88182/88184 1.000 Ch12 Mouse GSM Med 185.8 to 186.6 182.81 0.38/8.21 125.8 214.8 88086/88184 0.999 Ch14 Mouse GSM Low 130.8 to 131.9 123.35 0.24/3.44 103.5 152.6 88180/88184 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 88184/88184 1.000 I-14 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE I3 Summary of GSM-Modulated Cell Phone RFR Exposure Data – E-Field Target Range Mean Stdev Min Max In Range/ Chamber [V/m] [V/m] [dB]/[V/m] [V/m] [V/m] Total Ratio March 1 to 31, 2014 Ch11 Mouse GSM High 275.0 to 276.1 261.60 0.57/17.65 199.8 325.6 96810/97142 0.997 Ch12 Mouse GSM Med 186.6 to 186.6 178.89 0.67/14.44 138.6 218.0 96626/97142 0.995 Ch14 Mouse GSM Low 131.4 to 131.9 124.02 0.24/3.40 105.7 138.7 97142/97142 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 97142/97142 1.000 April 1 to 30, 2014 Ch11 Mouse GSM High 273.8 to 275.0 264.65 0.57/18.01 203.2 327.8 94118/94548 0.995 Ch12 Mouse GSM Med 185.8 to 186.6 182.58 0.71/15.58 129.0 246.4 93222/94548 0.986 Ch14 Mouse GSM Low 130.8 to 131.4 122.29 0.23/3.35 106.3 141.5 94548/94548 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 94548/94548 1.000 May 1 to 31, 2014 Ch11 Mouse GSM High 272.7 to 273.8 268.70 0.37/11.81 201.7 319.0 97086/97244 0.998 Ch12 Mouse GSM Med 185.0 to 185.8 184.59 0.34/7.30 131.9 223.2 97154/97244 0.999 Ch14 Mouse GSM Low 130.8 to 130.8 122.38 0.23/3.30 108.2 136.7 97244/97244 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 97244/97244 1.000 June 1 to 30, 2014 Ch11 Mouse GSM High 271.5 to 272.7 275.38 0.41/13.20 222.4 327.6 94288/94288 1.000 Ch12 Mouse GSM Med 184.2 to 185.0 180.65 0.26/5.58 141.8 202.2 94282/94288 1.000 Ch14 Mouse GSM Low 130.3 to 130.8 123.72 0.23/3.37 110.5 137.5 94288/94288 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 94288/94288 1.000 July 1 to 9, 2014 Ch11 Mouse GSM High 271.5 to 271.5 281.98 0.27/8.95 242.7 312.4 25064/25064 1.000 Ch12 Mouse GSM Med 184.2 to 184.2 185.84 0.22/4.78 169.6 201.3 25064/25064 1.000 Ch14 Mouse GSM Low 130.3 to 130.3 125.14 0.23/3.34 113.1 138.1 25064/25064 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 25064/25064 1.000 June 18, 2012, to July 9, 2014 Ch11 Mouse GSM High 194.1 to 276.1 259.29 0.88/27.75 134.8 380.5 2265600/2272442 0.997 Ch12 Mouse GSM Med 137.2 to 186.6 179.13 0.47/9.94 93.1 246.4 2270352/2272416 0.999 Ch14 Mouse GSM Low 97.0 to 131.9 118.53 0.26/3.55 54.4 157.5 2272352/2272416 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 2272416/2272416 1.000 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 I-15 Peer Review Draft NOT FOR ATTRIBUTION TABLE I4 Summary of GSM-Modulated Cell Phone RFR Exposure Data – H-Fielda Target Range Mean Stdev Min Max In Range/ Chamber [V/m] [V/m] [dB]/[V/m] [V/m] [V/m] Total Ratio June 18 to 30, 2012 Ch11 Mouse GSM High 0.52 to 0.53 0.462 0.26/0.014 0.29 0.67 38922/38950 0.999 Ch12 Mouse GSM Med 0.36 to 0.38 0.347 0.27/0.011 0.23 0.53 38944/38950 1.000 Ch14 Mouse GSM Low 0.26 to 0.27 0.275 0.29/0.009 0.25 0.31 38950/38950 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 38950/38950 1.000 July 1 to 31, 2012 Ch11 Mouse GSM High 0.53 to 0.56 0.476 0.33/0.018 0.40 0.57 96830/97462 0.994 Ch12 Mouse GSM Med 0.38 to 0.40 0.363 0.25/0.011 0.30 0.42 97458/97462 1.000 Ch14 Mouse GSM Low 0.27 to 0.28 0.292 0.27/0.009 0.26 0.33 97462/97462 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 97462/97462 1.000 August 1 to 31, 2012 Ch11 Mouse GSM High 0.56 to 0.59 0.485 0.29/0.017 0.40 0.56 93530/94976 0.985 Ch12 Mouse GSM Med 0.40 to 0.42 0.381 0.25/0.011 0.33 0.45 94976/94976 1.000 Ch14 Mouse GSM Low 0.28 to 0.30 0.306 0.26/0.009 0.27 0.37 94976/94976 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 94976/94976 1.000 September 1 to 30, 2012 Ch11 Mouse GSM High 0.59 to 0.61 0.492 0.26/0.015 0.35 0.55 88558/94374 0.938 Ch12 Mouse GSM Med 0.42 to 0.43 0.397 0.25/0.012 0.30 0.45 94362/94370 1.000 Ch14 Mouse GSM Low 0.30 to 0.30 0.316 0.26/0.009 0.25 0.36 94370/94370 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 94370/94370 1.000 October 1 to 31, 2012 Ch11 Mouse GSM High 0.61 to 0.63 0.515 0.25/0.015 0.29 0.58 95516/97604 0.979 Ch12 Mouse GSM Med 0.43 to 0.45 0.419 0.25/0.012 0.34 0.49 97602/97602 1.000 Ch14 Mouse GSM Low 0.30 to 0.31 0.324 0.26/0.010 0.28 0.36 97602/97602 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 97602/97602 1.000 November 1 to 30, 2012 Ch11 Mouse GSM High 0.63 to 0.64 0.529 0.25/0.015 0.47 0.61 91670/94628 0.969 Ch12 Mouse GSM Med 0.45 to 0.46 0.439 0.24/0.012 0.37 0.49 94628/94628 1.000 Ch14 Mouse GSM Low 0.31 to 0.32 0.335 0.26/0.010 0.29 0.38 94628/94628 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 94628/94628 1.000 December 1 to 31, 2012 Ch11 Mouse GSM High 0.64 to 0.66 0.532 0.24/0.015 0.47 0.60 90788/97500 0.931 Ch12 Mouse GSM Med 0.46 to 0.46 0.445 0.23/0.012 0.40 0.50 97496/97496 1.000 Ch14 Mouse GSM Low 0.32 to 0.33 0.339 0.25/0.010 0.29 0.38 97496/97496 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 97496/97496 1.000 a Ch=chamber (e.g., Ch11=Chamber 11) I-16 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE I4 Summary of GSM-Modulated Cell Phone RFR Exposure Data – H-Field Target Range Mean Stdev Min Max In Range/ Chamber [V/m] [V/m] [dB]/[V/m] [V/m] [V/m] Total Ratio January 1 to 31, 2013 Ch11 Mouse GSM High 0.66 to 0.66 0.550 0.32/0.021 0.46 0.63 91600/97378 0.941 Ch12 Mouse GSM Med 0.46 to 0.47 0.450 0.28/0.015 0.35 0.54 97286/97364 0.999 Ch14 Mouse GSM Low 0.33 to 0.33 0.343 0.25/0.010 0.31 0.39 97364/97364 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 97364/97364 1.000 February 1 to 28, 2013 Ch11 Mouse GSM High 0.66 to 0.67 0.554 0.23/0.015 0.49 0.62 86086/88116 0.977 Ch12 Mouse GSM Med 0.47 to 0.47 0.450 0.22/0.012 0.40 0.50 88116/88116 1.000 Ch14 Mouse GSM Low 0.33 to 0.33 0.349 0.24/0.010 0.29 0.39 88116/88116 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 88116/88116 1.000 March 1 to 31, 2013 Ch11 Mouse GSM High 0.67 to 0.67 0.559 0.25/0.016 0.49 0.63 94850/97784 0.970 Ch12 Mouse GSM Med 0.47 to 0.48 0.456 0.25/0.013 0.40 0.52 97784/97784 1.000 Ch14 Mouse GSM Low 0.33 to 0.34 0.348 0.24/0.010 0.31 0.39 97784/97784 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 97784/97784 1.000 April 1 to 30, 2013 Ch11 Mouse GSM High 0.67 to 0.68 0.553 0.21/0.014 0.49 0.62 91198/96260 0.947 Ch12 Mouse GSM Med 0.48 to 0.48 0.458 0.22/0.012 0.40 0.50 96260/96260 1.000 Ch14 Mouse GSM Low 0.34 to 0.34 0.356 0.26/0.011 0.31 0.39 96260/96260 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 96260/96260 1.000 May 1 to 31, 2013 Ch11 Mouse GSM High 0.68 to 0.68 0.558 0.22/0.014 0.45 0.62 92216/97020 0.950 Ch12 Mouse GSM Med 0.48 to 0.48 0.476 0.33/0.018 0.37 0.58 97018/97020 1.000 Ch14 Mouse GSM Low 0.34 to 0.34 0.350 0.25/0.010 0.31 0.39 97020/97020 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 97020/97020 1.000 June 1 to 30, 2013 Ch11 Mouse GSM High 0.68 to 0.69 0.546 0.23/0.015 0.48 0.60 81918/94496 0.867 Ch12 Mouse GSM Med 0.48 to 0.49 0.492 0.25/0.014 0.45 0.56 94496/94496 1.000 Ch14 Mouse GSM Low 0.34 to 0.34 0.359 0.24/0.010 0.32 0.39 94496/94496 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 94496/94496 1.000 July 1 to 31, 2013 Ch11 Mouse GSM High 0.69 to 0.69 0.562 0.25/0.016 0.45 0.63 92320/99146 0.931 Ch12 Mouse GSM Med 0.49 to 0.49 0.498 0.25/0.014 0.41 0.55 99146/99146 1.000 Ch14 Mouse GSM Low 0.34 to 0.35 0.362 0.26/0.011 0.32 0.40 99146/99146 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 99146/99146 1.000 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 I-17 Peer Review Draft NOT FOR ATTRIBUTION TABLE I4 Summary of GSM-Modulated Cell Phone RFR Exposure Data – H-Field Target Range Mean Stdev Min Max In Range/ Chamber [V/m] [V/m] [dB]/[V/m] [V/m] [V/m] Total Ratio August 1 to 31, 2013 Ch11 Mouse GSM High 0.69 to 0.69 0.632 0.45/0.034 0.51 0.78 101140/101700 0.994 Ch12 Mouse GSM Med 0.49 to 0.49 0.502 0.27/0.016 0.44 0.58 101700/101700 1.000 Ch14 Mouse GSM Low 0.35 to 0.35 0.362 0.26/0.011 0.32 0.43 101700/101700 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 101700/101700 1.000 September 1 to 30, 2013 Ch11 Mouse GSM High 0.69 to 0.73 0.709 0.53/0.044 0.39 0.88 93920/93922 1.000 Ch12 Mouse GSM Med 0.49 to 0.50 0.506 0.27/0.016 0.46 0.58 93920/93920 1.000 Ch14 Mouse GSM Low 0.35 to 0.35 0.365 0.25/0.011 0.27 0.40 93914/93920 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 93920/93920 1.000 October 1 to 31, 2013 Ch11 Mouse GSM High 0.73 to 0.73 0.748 0.38/0.033 0.61 0.89 100816/100816 1.000 Ch12 Mouse GSM Med 0.50 to 0.50 0.506 0.27/0.016 0.41 0.59 100816/100816 1.000 Ch14 Mouse GSM Low 0.35 to 0.35 0.368 0.26/0.011 0.29 0.43 100816/100816 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 100816/100816 1.000 November 1 to 30, 2013 Ch11 Mouse GSM High 0.73 to 0.73 0.679 0.44/0.036 0.49 0.83 93208/93226 1.000 Ch12 Mouse GSM Med 0.50 to 0.50 0.496 0.29/0.017 0.40 0.60 93226/93226 1.000 Ch14 Mouse GSM Low 0.35 to 0.35 0.361 0.28/0.012 0.28 0.41 93226/93226 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 93226/93226 1.000 December 1 to 31, 2013 Ch11 Mouse GSM High 0.73 to 0.73 0.699 0.48/0.040 0.56 0.82 96800/96846 1.000 Ch12 Mouse GSM Med 0.49 to 0.50 0.502 0.31/0.018 0.41 0.62 96846/96846 1.000 Ch14 Mouse GSM Low 0.35 to 0.35 0.369 0.26/0.011 0.28 0.48 96844/96846 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 96846/96846 1.000 January 1 to 31, 2014 Ch11 Mouse GSM High 0.73 to 0.73 0.691 0.32/0.026 0.55 0.82 97548/97550 1.000 Ch12 Mouse GSM Med 0.49 to 0.49 0.505 0.27/0.016 0.41 0.58 97550/97550 1.000 Ch14 Mouse GSM Low 0.35 to 0.35 0.366 0.26/0.011 0.16 0.44 97538/97550 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 97550/97550 1.000 February 1 to 28, 2014 Ch11 Mouse GSM High 0.73 to 0.73 0.704 0.35/0.029 0.59 0.82 88184/88184 1.000 Ch12 Mouse GSM Med 0.49 to 0.50 0.461 0.68/0.038 0.32 0.57 87662/88184 0.994 Ch14 Mouse GSM Low 0.35 to 0.35 0.372 0.25/0.011 0.29 0.46 88176/88184 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 88184/88184 1.000 I-18 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE I4 Summary of GSM-Modulated Cell Phone RFR Exposure Data – H-Field Target Range Mean Stdev Min Max In Range/ Chamber [V/m] [V/m] [dB]/[V/m] [V/m] [V/m] Total Ratio March 1 to 31, 2014 Ch11 Mouse GSM High 0.73 to 0.73 0.718 0.48/0.041 0.59 0.88 97142/97142 1.000 Ch12 Mouse GSM Med 0.50 to 0.50 0.466 0.74/0.041 0.33 0.59 93996/97142 0.968 Ch14 Mouse GSM Low 0.35 to 0.35 0.370 0.23/0.010 0.33 0.41 97142/97142 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 97142/97142 1.000 April 1 to 30, 2014 Ch11 Mouse GSM High 0.73 to 0.73 0.737 0.46/0.040 0.60 0.88 94548/94548 1.000 Ch12 Mouse GSM Med 0.49 to 0.50 0.492 0.81/0.048 0.34 0.68 92916/94548 0.983 Ch14 Mouse GSM Low 0.35 to 0.35 0.372 0.24/0.010 0.32 0.41 94548/94548 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 94548/94548 1.000 May 1 to 31, 2014 Ch11 Mouse GSM High 0.72 to 0.73 0.739 0.34/0.030 0.60 0.85 97244/97244 1.000 Ch12 Mouse GSM Med 0.49 to 0.49 0.495 0.33/0.019 0.36 0.61 97052/97244 0.998 Ch14 Mouse GSM Low 0.35 to 0.35 0.370 0.22/0.010 0.34 0.41 97244/97244 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 97244/97244 1.000 June 1 to 30, 2014 Ch11 Mouse GSM High 0.72 to 0.72 0.716 0.36/0.031 0.63 0.84 94288/94288 1.000 Ch12 Mouse GSM Med 0.49 to 0.49 0.501 0.25/0.015 0.38 0.55 94284/94288 1.000 Ch14 Mouse GSM Low 0.35 to 0.35 0.366 0.23/0.010 0.33 0.40 94288/94288 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 94288/94288 1.000 July 1 to 9, 2014 Ch11 Mouse GSM High 0.72 to 0.72 0.698 0.26/0.021 0.63 0.78 25064/25064 1.000 Ch12 Mouse GSM Med 0.49 to 0.49 0.487 0.23/0.013 0.45 0.54 25064/25064 1.000 Ch14 Mouse GSM Low 0.35 to 0.35 0.361 0.26/0.011 0.32 0.41 25064/25064 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 25064/25064 1.000 June 18, 2012, to July 9, 2014 Ch11 Mouse GSM High 0.52 to 0.73 0.607 0.73/0.053 0.29 0.89 2212122/2272442 0.973 Ch12 Mouse GSM Med 0.36 to 0.50 0.463 0.46/0.025 0.23 0.68 2266828/2272416 0.998 Ch14 Mouse GSM Low 0.26 to 0.35 0.349 0.26/0.011 0.16 0.48 2272388/2272416 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 2272416/2272416 1.000 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 I-19 Peer Review Draft NOT FOR ATTRIBUTION TABLE I5 Summary of CDMA-Modulated Cell Phone RFR Exposure Data – SARa Weight Range Target Mean Stdev Min Max In Range/ Chamber [g] [W/kg] [W/kg] [dB]/[W/kg] [W/kg] [W/kg] Total Ratio June 18 to 30, 2012 Ch01 Mouse IS95 High 18.9 to 20.2 10.00 9.98 0.13/0.03 5.483 20.437 19472/19475 1.000 Ch02 Mouse IS95 Med 18.9 to 20.2 5.00 4.94 0.17/0.04 3.641 7.729 19475/19475 1.000 Ch03 Mouse IS95 Low 18.9 to 20.1 2.50 2.49 0.11/0.03 2.134 3.273 19475/19475 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 19475/19475 1.000 July 1 to 31, 2012 Ch01 Mouse IS95 High 20.2 to 24.6 10.00 9.98 0.12/0.03 6.703 16.201 48730/48731 1.000 Ch02 Mouse IS95 Med 20.2 to 24.6 5.00 4.96 0.15/0.04 3.476 8.609 48730/48731 1.000 Ch03 Mouse IS95 Low 20.1 to 24.7 2.50 2.49 0.11/0.03 1.742 4.180 48730/48731 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 48731/48731 1.000 August 1 to 31, 2012 Ch01 Mouse IS95 High 24.6 to 28.0 10.00 9.98 0.12/0.03 8.349 13.937 47488/47488 1.000 Ch02 Mouse IS95 Med 24.6 to 27.6 5.00 4.96 0.14/0.03 4.115 9.356 47487/47488 1.000 Ch03 Mouse IS95 Low 24.7 to 27.6 2.50 2.49 0.11/0.03 2.031 3.689 47488/47488 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 47488/47488 1.000 September 1 to 30, 2012 Ch01 Mouse IS95 High 28.0 to 30.1 10.00 9.98 0.11/0.03 8.923 11.261 47187/47187 1.000 Ch02 Mouse IS95 Med 27.6 to 29.3 5.00 4.96 0.13/0.03 4.325 6.682 47187/47187 1.000 Ch03 Mouse IS95 Low 27.6 to 29.1 2.50 2.49 0.11/0.03 2.180 2.844 47187/47187 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 47185/47185 1.000 October 1 to 31, 2012 Ch01 Mouse IS95 High 30.1 to 33.3 10.00 9.97 0.11/0.03 8.718 11.420 48802/48802 1.000 Ch02 Mouse IS95 Med 29.3 to 32.6 5.00 4.98 0.13/0.03 4.296 5.798 48802/48802 1.000 Ch03 Mouse IS95 Low 29.1 to 32.4 2.50 2.49 0.10/0.02 2.208 2.766 48802/48802 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 48801/48801 1.000 November 1 to 30, 2012 Ch01 Mouse IS95 High 33.3 to 36.7 10.00 9.98 0.11/0.03 4.470 11.321 47313/47314 1.000 Ch02 Mouse IS95 Med 32.6 to 36.1 5.00 4.98 0.13/0.03 2.462 5.974 47313/47314 1.000 Ch03 Mouse IS95 Low 32.4 to 35.5 2.50 2.49 0.11/0.03 1.174 2.967 47313/47314 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 47314/47314 1.000 December 1 to 31, 2012 Ch01 Mouse IS95 High 36.7 to 39.1 10.00 10.01 0.11/0.03 8.925 11.723 48750/48750 1.000 Ch02 Mouse IS95 Med 36.1 to 38.5 5.00 4.98 0.13/0.03 4.364 6.018 48750/48750 1.000 Ch03 Mouse IS95 Low 35.5 to 38.2 2.50 2.50 0.11/0.03 2.227 2.909 48750/48750 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 48748/48748 1.000 a Ch=chamber (e.g., Ch01=Chamber 1) I-20 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE I5 Summary of CDMA-Modulated Cell Phone RFR Exposure Data – SAR Weight Range Target Mean Stdev Min Max In Range/ Chamber [g] [W/kg] [W/kg] [dB]/[W/kg] [W/kg] [W/kg] Total Ratio January 1 to 31, 2013 Ch01 Mouse IS95 High 39.1 to 41.1 10.00 9.98 0.12/0.03 8.549 11.885 48689/48689 1.000 Ch02 Mouse IS95 Med 38.5 to 40.8 5.00 4.98 0.13/0.03 4.218 5.822 48689/48689 1.000 Ch03 Mouse IS95 Low 38.2 to 40.8 2.50 2.50 0.11/0.03 2.161 2.957 48689/48689 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 48682/48682 1.000 February 1 to 28, 2013 Ch01 Mouse IS95 High 41.1 to 43.1 10.00 9.98 0.12/0.03 8.591 11.811 44058/44058 1.000 Ch02 Mouse IS95 Med 40.8 to 42.7 5.00 4.99 0.14/0.03 3.890 7.124 44058/44058 1.000 Ch03 Mouse IS95 Low 40.8 to 42.6 2.50 2.50 0.11/0.03 2.117 3.036 44058/44058 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 44058/44058 1.000 March 1 to 31, 2013 Ch01 Mouse IS95 High 43.1 to 44.9 10.00 10.01 0.12/0.03 8.731 11.338 48892/48892 1.000 Ch02 Mouse IS95 Med 42.7 to 44.3 5.00 5.00 0.14/0.03 4.271 6.209 48892/48892 1.000 Ch03 Mouse IS95 Low 42.6 to 44.0 2.50 2.50 0.11/0.03 2.213 2.833 48892/48892 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 48892/48892 1.000 April 1 to 30, 2013 Ch01 Mouse IS95 High 44.9 to 47.8 10.00 10.00 0.12/0.03 8.512 12.723 48130/48130 1.000 Ch02 Mouse IS95 Med 44.3 to 47.5 5.00 4.98 0.14/0.03 4.329 5.899 48130/48130 1.000 Ch03 Mouse IS95 Low 44.0 to 47.2 2.50 2.49 0.12/0.03 2.196 2.858 48130/48130 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 48130/48130 1.000 May 1 to 31, 2013 Ch01 Mouse IS95 High 47.8 to 49.2 10.00 9.99 0.14/0.03 7.772 12.345 48510/48510 1.000 Ch02 Mouse IS95 Med 47.5 to 49.1 5.00 4.97 0.14/0.03 4.225 6.364 48510/48510 1.000 Ch03 Mouse IS95 Low 47.2 to 48.5 2.50 2.49 0.12/0.03 2.170 3.006 48510/48510 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 48510/48510 1.000 June 1 to 30, 2013 Ch01 Mouse IS95 High 49.2 to 50.4 10.00 10.02 0.15/0.03 7.714 12.935 47257/47257 1.000 Ch02 Mouse IS95 Med 49.1 to 50.4 5.00 4.99 0.14/0.03 4.037 6.047 47257/47257 1.000 Ch03 Mouse IS95 Low 48.5 to 50.2 2.50 2.50 0.25/0.06 1.455 3.737 47253/47257 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 47248/47248 1.000 July 1 to 31, 2013 Ch01 Mouse IS95 High 50.4 to 51.6 10.00 9.99 0.16/0.04 7.808 13.620 49573/49573 1.000 Ch02 Mouse IS95 Med 50.4 to 51.7 5.00 4.97 0.14/0.03 4.158 6.040 49573/49573 1.000 Ch03 Mouse IS95 Low 50.2 to 51.4 2.50 2.50 0.28/0.07 1.626 3.683 49573/49573 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 49573/49573 1.000 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 I-21 Peer Review Draft NOT FOR ATTRIBUTION TABLE I5 Summary of CDMA-Modulated Cell Phone RFR Exposure Data – SAR Weight Range Target Mean Stdev Min Max In Range/ Chamber [g] [W/kg] [W/kg] [dB]/[W/kg] [W/kg] [W/kg] Total Ratio August 1 to 31, 2013 Ch01 Mouse IS95 High 51.6 to 52.2 10.00 9.99 0.14/0.03 7.168 12.173 50856/50856 1.000 Ch02 Mouse IS95 Med 51.7 to 52.7 5.00 4.99 0.16/0.04 4.279 6.445 50856/50856 1.000 Ch03 Mouse IS95 Low 51.3 to 52.2 2.50 2.50 0.14/0.03 1.851 3.071 50856/50856 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 50850/50850 1.000 September 1 to 30, 2013 Ch01 Mouse IS95 High 52.2 to 53.0 10.95 10.11 0.14/0.03 8.045 13.922 46961/46961 1.000 Ch02 Mouse IS95 Med 52.7 to 53.5 5.00 5.00 0.15/0.03 4.143 6.336 46961/46961 1.000 Ch03 Mouse IS95 Low 52.2 to 53.4 2.50 2.51 0.35/0.08 1.262 4.130 46946/46961 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 46960/46960 1.000 October 1 to 31, 2013 Ch01 Mouse IS95 High 53.0 to 53.8 10.00 10.03 0.13/0.03 8.027 12.009 50408/50408 1.000 Ch02 Mouse IS95 Med 53.5 to 54.2 5.00 4.99 0.15/0.03 4.224 6.669 50408/50408 1.000 Ch03 Mouse IS95 Low 53.4 to 54.1 2.50 2.50 0.16/0.04 1.718 3.359 50408/50408 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 50408/50408 1.000 November 1 to 30, 2013 Ch01 Mouse IS95 High 53.8 to 54.0 10.00 10.03 0.15/0.04 4.536 12.268 46637/46639 1.000 Ch02 Mouse IS95 Med 54.2 to 54.2 5.00 4.98 0.16/0.04 2.225 6.187 46637/46639 1.000 Ch03 Mouse IS95 Low 53.8 to 54.1 2.50 2.48 0.27/0.06 0.161 4.469 46551/46639 0.998 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 46613/46613 1.000 December 1 to 31, 2013 Ch01 Mouse IS95 High 52.3 to 54.0 10.00 10.02 0.14/0.03 7.143 14.712 48423/48423 1.000 Ch02 Mouse IS95 Med 52.8 to 54.2 5.00 4.99 0.16/0.04 3.949 7.068 48423/48423 1.000 Ch03 Mouse IS95 Low 52.6 to 53.8 2.50 2.50 0.14/0.03 1.989 3.035 48423/48423 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 48423/48423 1.000 January 1 to 31, 2014 Ch01 Mouse IS95 High 52.3 to 52.7 10.00 9.99 0.14/0.03 6.121 14.242 48776/48777 1.000 Ch02 Mouse IS95 Med 52.8 to 53.4 5.00 5.00 0.15/0.04 1.378 6.481 48775/48777 1.000 Ch03 Mouse IS95 Low 52.6 to 53.0 2.50 2.51 0.31/0.07 0.429 4.110 48768/48776 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 48775/48775 1.000 February 1 to 28, 2014 Ch01 Mouse IS95 High 52.7 to 54.1 10.00 9.95 0.13/0.03 6.403 13.519 44092/44092 1.000 Ch02 Mouse IS95 Med 53.4 to 54.8 5.00 4.98 0.16/0.04 2.326 9.889 44085/44092 1.000 Ch03 Mouse IS95 Low 53.0 to 54.6 2.50 2.48 0.35/0.08 1.358 3.784 44059/44092 0.999 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 44092/44092 1.000 I-22 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE I5 Summary of CDMA-Modulated Cell Phone RFR Exposure Data – SAR Weight Range Target Mean Stdev Min Max In Range/ Chamber [g] [W/kg] [W/kg] [dB]/[W/kg] [W/kg] [W/kg] Total Ratio March 1 to 31, 2014 Ch01 Mouse IS95 High 53.0 to 54.1 10.00 9.45 0.48/0.12 0.124 18.080 48470/48590 0.998 Ch02 Mouse IS95 Med 53.8 to 54.9 5.00 5.00 0.16/0.04 2.146 9.590 48585/48590 1.000 Ch03 Mouse IS95 Low 54.2 to 54.7 2.50 2.47 0.35/0.08 0.607 6.319 48505/48590 0.998 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 48571/48571 1.000 April 1 to 30, 2014 Ch01 Mouse IS95 High 51.8 to 52.8 10.00 9.96 0.21/0.05 0.435 21.444 47241/47275 0.999 Ch02 Mouse IS95 Med 52.9 to 53.2 5.00 5.02 0.21/0.05 0.771 12.768 47238/47275 0.999 Ch03 Mouse IS95 Low 53.3 to 53.8 2.50 2.48 0.27/0.06 0.656 3.495 47261/47275 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 47274/47274 1.000 May 1 to 31, 2014 Ch01 Mouse IS95 High 51.0 to 51.8 10.00 9.98 0.14/0.03 8.159 12.373 48622/48622 1.000 Ch02 Mouse IS95 Med 51.4 to 52.9 5.00 5.00 0.14/0.03 3.701 6.542 48622/48622 1.000 Ch03 Mouse IS95 Low 52.2 to 53.3 2.50 2.49 0.27/0.06 1.281 3.566 48619/48622 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 48622/48622 1.000 June 1 to 30, 2014 Ch01 Mouse IS95 High 50.5 to 51.2 10.00 9.97 0.13/0.03 7.103 12.077 47144/47144 1.000 Ch02 Mouse IS95 Med 51.0 to 51.4 5.00 5.00 0.14/0.03 3.476 6.143 47144/47144 1.000 Ch03 Mouse IS95 Low 50.6 to 52.2 2.50 2.49 0.28/0.07 1.038 4.032 47132/47144 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 47144/47144 1.000 July 1 to 9, 2014 Ch01 Mouse IS95 High 51.2 to 51.2 10.00 10.00 0.11/0.03 8.426 11.320 12549/12549 1.000 Ch02 Mouse IS95 Med 51.3 to 51.3 5.00 4.99 0.12/0.03 4.148 5.780 12549/12549 1.000 Ch03 Mouse IS95 Low 50.6 to 50.6 2.50 2.53 0.65/0.16 0.633 4.854 12390/12549 0.987 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 12532/12532 1.000 June 18, 2012, to July 9, 2014 Ch01 Mouse IS95 High 18.9 to 54.1 10.95 9.97 0.17/0.04 0.124 21.444 1136122/1136284 1.000 Ch02 Mouse IS95 Med 18.9 to 54.9 5.00 4.99 0.15/0.03 0.771 12.768 1136228/1136284 1.000 Ch03 Mouse IS95 Low 18.9 to 54.7 2.50 2.49 0.21/0.05 0.161 6.319 1136030/1136283 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 0.00 –/0.00 0.000 0.000 1136208/1136208 1.000 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 I-23 Peer Review Draft NOT FOR ATTRIBUTION TABLE I6 Summary of CDMA-Modulated Cell Phone RFR Exposure Data – Chamber Fielda Target Range Mean Stdev Min Max In Range/ Chamber [V/m] [V/m] [dB]/[V/m] [V/m] [V/m] Total Ratio June 18 to 30, 2012 Ch01 Mouse IS95 High 194.10 to 199.60 196.37 0.13/2.96 143.58 277.18 38944/38950 1.000 Ch02 Mouse IS95 Med 137.20 to 141.20 138.19 0.17/2.76 120.44 170.46 38950/38950 1.000 Ch03 Mouse IS95 Low 97.00 to 99.80 98.08 0.12/1.31 91.19 110.93 38950/38950 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 38950/38950 1.000 July 1 to 31, 2012 Ch01 Mouse IS95 High 199.60 to 212.30 205.11 0.12/2.82 173.76 270.15 97460/97462 1.000 Ch02 Mouse IS95 Med 141.20 to 150.10 145.03 0.15/2.59 125.14 196.92 97460/97462 1.000 Ch03 Mouse IS95 Low 99.80 to 106.10 103.17 0.11/1.37 88.58 137.22 97460/97462 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 97462/97462 1.000 August 1 to 31, 2012 Ch01 Mouse IS95 High 212.30 to 222.20 217.26 0.12/2.98 199.87 258.23 94976/94976 1.000 Ch02 Mouse IS95 Med 150.10 to 157.10 152.68 0.15/2.58 138.34 208.61 94974/94976 1.000 Ch03 Mouse IS95 Low 106.10 to 111.10 108.44 0.11/1.37 98.59 132.85 94976/94976 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 94976/94976 1.000 September 1 to 30, 2012 Ch01 Mouse IS95 High 222.20 to 230.90 227.67 0.11/2.97 212.83 244.74 94374/94374 1.000 Ch02 Mouse IS95 Med 157.10 to 161.40 159.33 0.13/2.37 148.22 184.17 94374/94374 1.000 Ch03 Mouse IS95 Low 111.10 to 114.10 112.90 0.11/1.46 104.64 121.19 94374/94374 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 94370/94370 1.000 October 1 to 31, 2012 Ch01 Mouse IS95 High 230.90 to 237.60 233.91 0.11/3.07 215.34 250.45 97604/97604 1.000 Ch02 Mouse IS95 Med 161.40 to 166.60 163.67 0.13/2.46 151.48 176.83 97604/97604 1.000 Ch03 Mouse IS95 Low 114.10 to 117.80 115.72 0.11/1.42 108.66 123.97 97604/97604 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 97602/97602 1.000 November 1 to 30, 2012 Ch01 Mouse IS95 High 237.60 to 242.70 240.37 0.11/3.13 158.92 257.10 94626/94628 1.000 Ch02 Mouse IS95 Med 166.60 to 171.70 169.18 0.13/2.58 116.96 185.43 94626/94628 1.000 Ch03 Mouse IS95 Low 117.80 to 120.60 119.29 0.12/1.60 80.77 131.35 94626/94628 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 94628/94628 1.000 December 1 to 31, 2012 Ch01 Mouse IS95 High 242.70 to 247.20 245.58 0.11/3.21 231.33 264.34 97500/97500 1.000 Ch02 Mouse IS95 Med 171.70 to 173.80 172.59 0.13/2.64 162.14 190.41 97500/97500 1.000 Ch03 Mouse IS95 Low 120.60 to 122.90 121.97 0.11/1.55 113.87 132.39 97500/97500 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 97496/97496 1.000 a Ch=chamber (e.g., Ch01=Chamber 1) I-24 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE I6 Summary of CDMA-Modulated Cell Phone RFR Exposure Data – Chamber Field Target Range Mean Stdev Min Max In Range/ Chamber [V/m] [V/m] [dB]/[V/m] [V/m] [V/m] Total Ratio January 1 to 31, 2013 Ch01 Mouse IS95 High 247.20 to 249.80 249.07 0.12/3.50 230.99 272.55 97378/97378 1.000 Ch02 Mouse IS95 Med 173.80 to 175.70 174.88 0.13/2.63 161.36 189.41 97378/97378 1.000 Ch03 Mouse IS95 Low 122.90 to 124.30 123.76 0.11/1.65 115.26 135.11 97378/97378 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 97364/97364 1.000 February 1 to 28, 2013 Ch01 Mouse IS95 High 249.80 to 252.40 251.73 0.12/3.39 233.92 274.28 88116/88116 1.000 Ch02 Mouse IS95 Med 175.70 to 177.60 176.86 0.14/2.85 156.42 211.68 88116/88116 1.000 Ch03 Mouse IS95 Low 124.30 to 125.60 125.26 0.12/1.67 115.38 138.19 88116/88116 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 88116/88116 1.000 March 1 to 31, 2013 Ch01 Mouse IS95 High 252.40 to 253.60 253.18 0.12/3.50 236.57 269.59 97784/97784 1.000 Ch02 Mouse IS95 Med 177.60 to 179.30 178.79 0.14/2.88 165.47 199.50 97784/97784 1.000 Ch03 Mouse IS95 Low 125.60 to 126.20 125.98 0.11/1.61 118.72 133.49 97784/97784 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 97784/97784 1.000 April 1 to 30, 2013 Ch01 Mouse IS95 High 253.60 to 257.20 255.59 0.12/3.58 235.87 288.37 96260/96260 1.000 Ch02 Mouse IS95 Med 179.30 to 181.80 179.86 0.14/2.87 167.66 195.71 96260/96260 1.000 Ch03 Mouse IS95 Low 126.20 to 128.60 127.23 0.12/1.72 119.08 136.24 96260/96260 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 96260/96260 1.000 May 1 to 31, 2013 Ch01 Mouse IS95 High 257.20 to 259.40 257.37 0.14/4.29 226.87 285.93 97020/97020 1.000 Ch02 Mouse IS95 Med 181.80 to 183.40 181.64 0.14/2.98 167.27 205.30 97020/97020 1.000 Ch03 Mouse IS95 Low 128.60 to 129.10 128.55 0.12/1.77 119.88 141.09 97020/97020 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 97020/97020 1.000 June 1 to 30, 2013 Ch01 Mouse IS95 High 259.40 to 260.60 259.64 0.15/4.39 227.53 294.63 94514/94514 1.000 Ch02 Mouse IS95 Med 183.40 to 184.20 183.31 0.14/3.05 164.59 201.45 94514/94514 1.000 Ch03 Mouse IS95 Low 129.10 to 130.30 129.22 0.25/3.81 98.48 159.44 94506/94514 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 94496/94496 1.000 July 1 to 31, 2013 Ch01 Mouse IS95 High 260.60 to 261.60 260.92 0.16/4.87 230.46 304.39 99146/99146 1.000 Ch02 Mouse IS95 Med 184.20 to 185.00 184.01 0.14/3.03 168.19 202.70 99146/99146 1.000 Ch03 Mouse IS95 Low 130.30 to 130.80 130.53 0.28/4.24 105.17 158.30 99146/99146 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 99146/99146 1.000 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 I-25 Peer Review Draft NOT FOR ATTRIBUTION TABLE I6 Summary of CDMA-Modulated Cell Phone RFR Exposure Data – Chamber Field Target Range Mean Stdev Min Max In Range/ Chamber [V/m] [V/m] [dB]/[V/m] [V/m] [V/m] Total Ratio August 1 to 31, 2013 Ch01 Mouse IS95 High 261.60 to 262.80 261.92 0.14/4.30 222.33 288.89 101712/101712 1.000 Ch02 Mouse IS95 Med 185.00 to 185.80 185.08 0.16/3.35 171.22 210.82 101712/101712 1.000 Ch03 Mouse IS95 Low 130.80 to 131.40 130.89 0.14/2.08 113.00 145.03 101712/101712 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 101700/101700 1.000 September 1 to 30, 2013 Ch01 Mouse IS95 High 262.80 to 275.00 264.04 0.14/4.41 235.55 309.86 93922/93922 1.000 Ch02 Mouse IS95 Med 185.80 to 186.60 186.05 0.15/3.20 169.04 209.04 93922/93922 1.000 Ch03 Mouse IS95 Low 131.40 to 131.90 131.72 0.35/5.41 93.28 169.36 93890/93922 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 93920/93920 1.000 October 1 to 31, 2013 Ch01 Mouse IS95 High 262.80 to 263.90 263.44 0.13/4.00 236.10 288.79 100816/100816 1.000 Ch02 Mouse IS95 Med 186.60 to 187.40 186.81 0.15/3.17 171.27 216.71 100816/100816 1.000 Ch03 Mouse IS95 Low 131.90 to 132.50 132.12 0.17/2.54 109.99 152.72 100816/100816 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 100816/100816 1.000 November 1 to 30, 2013 Ch01 Mouse IS95 High 263.90 to 263.90 263.87 0.15/4.69 177.48 291.88 93274/93278 1.000 Ch02 Mouse IS95 Med 187.40 to 187.40 187.21 0.16/3.50 125.18 208.73 93274/93278 1.000 Ch03 Mouse IS95 Low 131.90 to 132.50 131.56 0.33/5.16 33.46 176.17 93098/93278 0.998 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 93226/93226 1.000 December 1 to 31, 2013 Ch01 Mouse IS95 High 262.80 to 263.90 263.08 0.14/4.35 221.94 318.53 96846/96846 1.000 Ch02 Mouse IS95 Med 185.80 to 187.40 186.01 0.16/3.57 166.56 220.78 96846/96846 1.000 Ch03 Mouse IS95 Low 131.40 to 131.90 131.34 0.14/2.10 117.52 144.93 96846/96846 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 96846/96846 1.000 January 1 to 31, 2014 Ch01 Mouse IS95 High 262.80 to 262.80 262.41 0.14/4.18 205.46 313.40 97552/97554 1.000 Ch02 Mouse IS95 Med 185.80 to 186.60 186.14 0.16/3.37 97.83 212.15 97550/97554 1.000 Ch03 Mouse IS95 Low 131.40 to 131.40 131.41 0.31/4.82 54.39 168.36 97536/97552 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 97550/97550 1.000 February 1 to 28, 2014 Ch01 Mouse IS95 High 262.80 to 265.00 264.44 0.13/4.06 212.35 308.55 88184/88184 1.000 Ch02 Mouse IS95 Med 186.60 to 187.40 187.06 0.16/3.50 127.99 263.90 88170/88184 1.000 Ch03 Mouse IS95 Low 131.40 to 132.50 131.92 0.36/5.64 97.78 163.25 88120/88184 0.999 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 88184/88184 1.000 I-26 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE I6 Summary of CDMA-Modulated Cell Phone RFR Exposure Data – Chamber Field Target Range Mean Stdev Min Max In Range/ Chamber [V/m] [V/m] [dB]/[V/m] [V/m] [V/m] Total Ratio March 1 to 31, 2014 Ch01 Mouse IS95 High 262.80 to 265.00 255.18 0.64/19.48 22.44 353.11 96940/97180 0.998 Ch02 Mouse IS95 Med 186.60 to 187.40 187.10 0.16/3.42 122.08 258.06 97170/97180 1.000 Ch03 Mouse IS95 Low 132.50 to 132.50 131.79 0.38/5.91 65.38 210.94 97010/97180 0.998 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 97142/97142 1.000 April 1 to 30, 2014 Ch01 Mouse IS95 High 261.60 to 262.80 261.90 0.27/8.39 22.44 384.56 94478/94550 0.999 Ch02 Mouse IS95 Med 185.80 to 186.60 186.68 0.20/4.33 73.16 297.77 94476/94550 0.999 Ch03 Mouse IS95 Low 131.90 to 131.90 131.23 0.28/4.23 67.49 155.79 94522/94550 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 94548/94548 1.000 May 1 to 31, 2014 Ch01 Mouse IS95 High 260.60 to 261.60 261.26 0.14/4.17 236.40 291.11 97244/97244 1.000 Ch02 Mouse IS95 Med 185.00 to 185.80 185.64 0.14/2.95 159.77 212.41 97244/97244 1.000 Ch03 Mouse IS95 Low 131.40 to 131.90 131.27 0.28/4.25 94.32 156.82 97238/97244 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 97244/97244 1.000 June 1 to 30, 2014 Ch01 Mouse IS95 High 260.60 to 261.60 260.64 0.13/3.91 219.82 287.61 94288/94288 1.000 Ch02 Mouse IS95 Med 184.20 to 185.00 184.79 0.14/2.97 153.76 204.42 94288/94288 1.000 Ch03 Mouse IS95 Low 130.30 to 131.40 130.58 0.28/4.32 84.05 165.61 94264/94288 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 94288/94288 1.000 July 1 to 9, 2014 Ch01 Mouse IS95 High 261.60 to 261.60 261.65 0.11/3.45 240.24 278.45 25098/25098 1.000 Ch02 Mouse IS95 Med 185.00 to 185.00 184.91 0.12/2.53 168.56 198.96 25098/25098 1.000 Ch03 Mouse IS95 Low 130.30 to 130.30 130.67 0.68/10.57 65.61 181.71 24784/25098 0.987 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 25064/25064 1.000 June 18, 2012, to July 9, 2014 Ch01 Mouse IS95 High 194.10 to 275.00 250.68 0.20/5.84 22.44 384.56 2272240/2272568 1.000 Ch02 Mouse IS95 Med 137.20 to 187.40 177.23 0.15/3.06 73.16 297.77 2272456/2272568 1.000 Ch03 Mouse IS95 Low 97.00 to 132.50 125.25 0.22/3.20 33.46 210.94 2272056/2272566 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.00 –/0.00 0.00 0.00 2272416/2272416 1.000 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 I-27 Peer Review Draft NOT FOR ATTRIBUTION TABLE I7 Summary of CDMA-Modulated Cell Phone RFR Exposure Data – E-Fielda Target Range Mean Stdev Min Max In Range/ Chamber [V/m] [V/m] [dB]/[V/m] [V/m] [V/m] Total Ratio June 18 to 30, 2012 Ch01 Mouse IS95 High 194.1 to 199.6 182.96 0.16/3.46 132.6 264.8 38944/38950 1.000 Ch02 Mouse IS95 Med 137.2 to 141.2 127.98 0.20/2.95 109.8 152.6 38926/38950 0.999 Ch03 Mouse IS95 Low 97.0 to 99.8 94.73 0.17/1.82 86.4 108.0 38950/38950 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 38950/38950 1.000 July 1 to 31, 2012 Ch01 Mouse IS95 High 199.6 to 212.3 191.13 0.18/3.93 161.2 251.6 97458/97462 1.000 Ch02 Mouse IS95 Med 141.2 to 150.1 134.04 0.20/3.16 115.7 186.0 97458/97462 1.000 Ch03 Mouse IS95 Low 99.8 to 106.1 99.09 0.17/1.98 83.9 131.8 97460/97462 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 97462/97462 1.000 August 1 to 31, 2012 Ch01 Mouse IS95 High 212.3 to 222.2 204.21 0.16/3.81 186.0 241.5 94976/94976 1.000 Ch02 Mouse IS95 Med 150.1 to 157.1 140.96 0.20/3.34 124.8 194.4 94974/94976 1.000 Ch03 Mouse IS95 Low 106.1 to 111.1 104.20 0.18/2.18 94.2 127.8 94976/94976 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 94976/94976 1.000 September 1 to 30, 2012 Ch01 Mouse IS95 High 222.2 to 230.9 214.97 0.17/4.21 191.7 239.8 94374/94374 1.000 Ch02 Mouse IS95 Med 157.1 to 161.4 147.53 0.18/3.03 133.9 170.0 94374/94374 1.000 Ch03 Mouse IS95 Low 111.1 to 114.1 107.71 0.17/2.09 98.9 118.0 94374/94374 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 94370/94370 1.000 October 1 to 31, 2012 Ch01 Mouse IS95 High 230.9 to 237.6 221.21 0.15/3.87 201.8 239.3 97604/97604 1.000 Ch02 Mouse IS95 Med 161.4 to 166.6 149.17 0.17/2.99 134.5 163.2 97604/97604 1.000 Ch03 Mouse IS95 Low 114.1 to 117.8 112.30 0.17/2.27 101.0 125.3 97604/97604 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 97602/97602 1.000 November 1 to 30, 2012 Ch01 Mouse IS95 High 237.6 to 242.7 227.51 0.17/4.54 151.4 254.3 94626/94628 1.000 Ch02 Mouse IS95 Med 166.6 to 171.7 154.82 0.18/3.32 104.7 176.2 94626/94628 1.000 Ch03 Mouse IS95 Low 117.8 to 120.6 116.59 0.17/2.36 76.7 128.5 94626/94628 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 94628/94628 1.000 December 1 to 31, 2012 Ch01 Mouse IS95 High 242.7 to 247.2 233.09 0.17/4.48 213.6 253.7 97500/97500 1.000 Ch02 Mouse IS95 Med 171.7 to 173.8 159.76 0.19/3.47 144.1 176.0 97500/97500 1.000 Ch03 Mouse IS95 Low 120.6 to 122.9 118.37 0.19/2.59 109.0 131.2 97500/97500 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 97496/97496 1.000 a Ch=chamber (e.g., Ch01=Chamber 1) I-28 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE I7 Summary of CDMA-Modulated Cell Phone RFR Exposure Data – E-Field Target Range Mean Stdev Min Max In Range/ Chamber [V/m] [V/m] [dB]/[V/m] [V/m] [V/m] Total Ratio January 1 to 31, 2013 Ch01 Mouse IS95 High 247.2 to 249.8 235.20 0.16/4.42 215.1 260.4 97378/97378 1.000 Ch02 Mouse IS95 Med 173.8 to 175.7 162.37 0.18/3.35 148.0 178.4 97378/97378 1.000 Ch03 Mouse IS95 Low 122.9 to 124.3 118.71 0.18/2.51 108.3 130.2 97378/97378 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 97364/97364 1.000 February 1 to 28, 2013 Ch01 Mouse IS95 High 249.8 to 252.4 238.62 0.16/4.53 217.4 264.4 88116/88116 1.000 Ch02 Mouse IS95 Med 175.7 to 177.6 162.29 0.19/3.61 141.3 193.5 88116/88116 1.000 Ch03 Mouse IS95 Low 124.3 to 125.6 119.75 0.19/2.59 109.5 131.5 88116/88116 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 88116/88116 1.000 March 1 to 31, 2013 Ch01 Mouse IS95 High 252.4 to 253.6 238.57 0.18/5.13 219.6 265.7 97784/97784 1.000 Ch02 Mouse IS95 Med 177.6 to 179.3 164.78 0.19/3.74 149.7 187.8 97784/97784 1.000 Ch03 Mouse IS95 Low 125.6 to 126.2 122.27 0.20/2.80 111.3 136.0 97784/97784 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 97784/97784 1.000 April 1 to 30, 2013 Ch01 Mouse IS95 High 253.6 to 257.2 242.43 0.19/5.50 219.5 273.9 96260/96260 1.000 Ch02 Mouse IS95 Med 179.3 to 181.8 167.11 0.18/3.58 151.5 185.2 96260/96260 1.000 Ch03 Mouse IS95 Low 126.2 to 128.6 123.32 0.18/2.59 113.4 135.4 96260/96260 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 96260/96260 1.000 May 1 to 31, 2013 Ch01 Mouse IS95 High 257.2 to 259.4 244.96 0.20/5.75 215.4 275.7 97020/97020 1.000 Ch02 Mouse IS95 Med 181.8 to 183.4 168.02 0.18/3.60 150.5 190.8 97020/97020 1.000 Ch03 Mouse IS95 Low 128.6 to 129.1 124.68 0.18/2.57 113.0 137.8 97020/97020 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 97020/97020 1.000 June 1 to 30, 2013 Ch01 Mouse IS95 High 259.4 to 260.6 246.98 0.21/5.93 212.0 288.6 94514/94514 1.000 Ch02 Mouse IS95 Med 183.4 to 184.2 170.19 0.18/3.64 154.4 190.5 94514/94514 1.000 Ch03 Mouse IS95 Low 129.1 to 130.3 128.47 0.64/9.79 88.7 176.8 94186/94514 0.997 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 94496/94496 1.000 July 1 to 31, 2013 Ch01 Mouse IS95 High 260.6 to 261.6 249.22 0.21/6.06 220.7 300.9 99146/99146 1.000 Ch02 Mouse IS95 Med 184.2 to 185.0 170.91 0.19/3.80 154.7 193.1 99146/99146 1.000 Ch03 Mouse IS95 Low 130.3 to 130.8 141.91 0.62/10.43 96.1 177.5 98928/99146 0.998 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 99146/99146 1.000 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 I-29 Peer Review Draft NOT FOR ATTRIBUTION TABLE I7 Summary of CDMA-Modulated Cell Phone RFR Exposure Data – E-Field Target Range Mean Stdev Min Max In Range/ Chamber [V/m] [V/m] [dB]/[V/m] [V/m] [V/m] Total Ratio August 1 to 31, 2013 Ch01 Mouse IS95 High 261.6 to 262.8 249.57 0.20/5.69 215.3 288.2 101712/101712 1.000 Ch02 Mouse IS95 Med 185.0 to 185.8 170.62 0.20/3.99 153.4 196.1 101712/101712 1.000 Ch03 Mouse IS95 Low 130.8 to 131.4 147.36 0.24/4.17 111.4 161.5 101712/101712 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 101700/101700 1.000 September 1 to 30, 2013 Ch01 Mouse IS95 High 262.8 to 275.0 254.31 0.20/6.01 220.4 300.7 93922/93922 1.000 Ch02 Mouse IS95 Med 185.8 to 186.6 171.99 0.19/3.87 155.0 194.2 93922/93922 1.000 Ch03 Mouse IS95 Low 131.4 to 131.9 136.81 0.82/13.59 85.5 183.6 93028/93922 0.990 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 93920/93920 1.000 October 1 to 31, 2013 Ch01 Mouse IS95 High 262.8 to 263.9 250.46 0.20/5.73 221.9 282.9 100816/100816 1.000 Ch02 Mouse IS95 Med 186.6 to 187.4 172.10 0.19/3.78 158.0 197.8 100816/100816 1.000 Ch03 Mouse IS95 Low 131.9 to 132.5 140.01 0.32/5.24 95.8 158.3 100766/100816 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 100816/100816 1.000 November 1 to 30, 2013 Ch01 Mouse IS95 High 263.9 to 263.9 254.87 0.21/6.33 172.3 287.3 93272/93278 1.000 Ch02 Mouse IS95 Med 187.4 to 187.4 173.77 0.22/4.48 116.2 196.2 93242/93278 1.000 Ch03 Mouse IS95 Low 131.9 to 132.5 139.81 0.43/7.11 34.8 193.8 92976/93278 0.997 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 93226/93226 1.000 December 1 to 31, 2013 Ch01 Mouse IS95 High 262.8 to 263.9 264.86 0.26/8.09 222.6 327.2 96846/96846 1.000 Ch02 Mouse IS95 Med 185.8 to 187.4 174.60 0.22/4.51 152.2 209.3 96846/96846 1.000 Ch03 Mouse IS95 Low 131.4 to 131.9 141.81 0.23/3.79 119.4 161.0 96846/96846 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 96846/96846 1.000 January 1 to 31, 2014 Ch01 Mouse IS95 High 262.8 to 262.8 259.88 0.24/7.35 197.0 322.5 97552/97554 1.000 Ch02 Mouse IS95 Med 185.8 to 186.6 171.64 0.20/4.08 93.5 198.8 97550/97554 1.000 Ch03 Mouse IS95 Low 131.4 to 131.4 138.63 0.57/9.33 56.5 182.3 96868/97552 0.993 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 97550/97550 1.000 February 1 to 28, 2014 Ch01 Mouse IS95 High 262.8 to 265.0 254.65 0.22/6.40 202.8 293.6 88182/88184 1.000 Ch02 Mouse IS95 Med 186.6 to 187.4 172.87 0.22/4.50 121.5 251.8 88162/88184 1.000 Ch03 Mouse IS95 Low 131.4 to 132.5 130.86 0.88/13.88 85.2 176.6 87104/88184 0.988 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 88184/88184 1.000 I-30 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE I7 Summary of CDMA-Modulated Cell Phone RFR Exposure Data – E-Field Target Range Mean Stdev Min Max In Range/ Chamber [V/m] [V/m] [dB]/[V/m] [V/m] [V/m] Total Ratio March 1 to 31, 2014 Ch01 Mouse IS95 High 262.8 to 265.0 248.73 0.66/19.55 21.5 370.2 96900/97180 0.997 Ch02 Mouse IS95 Med 186.6 to 187.4 178.11 0.21/4.32 114.7 249.5 97168/97180 1.000 Ch03 Mouse IS95 Low 132.5 to 132.5 125.83 0.60/8.93 56.2 202.2 96866/97180 0.997 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 97142/97142 1.000 April 1 to 30, 2014 Ch01 Mouse IS95 High 261.6 to 262.8 251.78 0.30/8.89 20.9 380.7 94432/94550 0.999 Ch02 Mouse IS95 Med 185.8 to 186.6 176.58 0.25/5.24 68.9 283.3 94536/94550 1.000 Ch03 Mouse IS95 Low 131.9 to 131.9 132.52 0.51/7.96 68.5 160.3 94454/94550 0.999 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 94548/94548 1.000 May 1 to 31, 2014 Ch01 Mouse IS95 High 260.6 to 261.6 250.61 0.21/6.02 218.6 280.8 97244/97244 1.000 Ch02 Mouse IS95 Med 185.0 to 185.8 174.90 0.18/3.74 145.3 200.0 97242/97244 1.000 Ch03 Mouse IS95 Low 131.4 to 131.9 129.23 0.53/8.16 89.0 165.6 97218/97244 1.000 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 97244/97244 1.000 June 1 to 30, 2014 Ch01 Mouse IS95 High 260.6 to 261.6 253.68 0.18/5.36 213.1 282.1 94288/94288 1.000 Ch02 Mouse IS95 Med 184.2 to 185.0 177.67 0.23/4.76 153.6 200.6 94288/94288 1.000 Ch03 Mouse IS95 Low 130.3 to 131.4 125.07 0.47/6.93 79.5 174.0 94236/94288 0.999 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 94288/94288 1.000 July 1 to 9, 2014 Ch01 Mouse IS95 High 261.6 to 261.6 259.20 0.16/4.71 236.0 277.7 25098/25098 1.000 Ch02 Mouse IS95 Med 185.0 to 185.0 184.69 0.16/3.33 168.3 199.6 25098/25098 1.000 Ch03 Mouse IS95 Low 130.3 to 130.3 127.53 0.87/13.46 60.8 192.7 24686/25098 0.984 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 25064/25064 1.000 June 18, 2012, to July 9, 2014 Ch01 Mouse IS95 High 194.1 to 275.0 239.79 0.28/7.76 20.9 380.7 2272148/2272568 1.000 Ch02 Mouse IS95 Med 137.2 to 187.4 164.41 0.22/4.14 68.9 283.3 2272446/2272568 1.000 Ch03 Mouse IS95 Low 97.0 to 132.5 125.83 0.60/9.02 34.8 202.2 2268550/2272566 0.998 Ch13 Mouse Sham 0.0 to 0.0 0.00 –/0.00 0.0 0.0 2272416/2272416 1.000 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 I-31 Peer Review Draft NOT FOR ATTRIBUTION TABLE I8 Summary of CDMA-Modulated Cell Phone RFR Exposure Data – H-Fielda Target Range Mean Stdev Min Max In Range/ Chamber [V/m] [V/m] [dB]/[V/m] [V/m] [V/m] Total Ratio June 18 to 30, 2012 Ch01 Mouse IS95 High 0.52 to 0.53 0.556 0.17/0.011 0.41 0.77 38948/38950 1.000 Ch02 Mouse IS95 Med 0.36 to 0.38 0.394 0.22/0.010 0.35 0.50 38948/38950 1.000 Ch03 Mouse IS95 Low 0.26 to 0.27 0.269 0.17/0.005 0.25 0.30 38950/38950 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 38950/38950 1.000 July 1 to 31, 2012 Ch01 Mouse IS95 High 0.53 to 0.56 0.581 0.19/0.013 0.49 0.77 97460/97462 1.000 Ch02 Mouse IS95 Med 0.38 to 0.40 0.414 0.21/0.010 0.36 0.55 97460/97462 1.000 Ch03 Mouse IS95 Low 0.27 to 0.28 0.284 0.17/0.005 0.25 0.38 97460/97462 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 97462/97462 1.000 August 1 to 31, 2012 Ch01 Mouse IS95 High 0.56 to 0.59 0.611 0.17/0.012 0.55 0.73 94976/94976 1.000 Ch02 Mouse IS95 Med 0.40 to 0.42 0.436 0.21/0.011 0.39 0.59 94974/94976 1.000 Ch03 Mouse IS95 Low 0.28 to 0.30 0.299 0.17/0.006 0.27 0.37 94974/94976 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 94976/94976 1.000 September 1 to 30, 2012 Ch01 Mouse IS95 High 0.59 to 0.61 0.638 0.17/0.013 0.58 0.69 94374/94374 1.000 Ch02 Mouse IS95 Med 0.42 to 0.43 0.454 0.19/0.010 0.42 0.53 94374/94374 1.000 Ch03 Mouse IS95 Low 0.30 to 0.30 0.313 0.17/0.006 0.29 0.35 94374/94374 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 94370/94370 1.000 October 1 to 31, 2012 Ch01 Mouse IS95 High 0.61 to 0.63 0.654 0.16/0.012 0.59 0.70 97604/97604 1.000 Ch02 Mouse IS95 Med 0.43 to 0.44 0.473 0.19/0.010 0.43 0.51 97604/97604 1.000 Ch03 Mouse IS95 Low 0.30 to 0.31 0.316 0.17/0.006 0.29 0.34 97604/97604 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 97602/97602 1.000 November 1 to 30, 2012 Ch01 Mouse IS95 High 0.63 to 0.64 0.672 0.17/0.013 0.44 0.72 94626/94628 1.000 Ch02 Mouse IS95 Med 0.44 to 0.46 0.487 0.22/0.012 0.34 0.54 94626/94628 1.000 Ch03 Mouse IS95 Low 0.31 to 0.32 0.324 0.17/0.006 0.23 0.36 94626/94628 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 94628/94628 1.000 December 1 to 31, 2012 Ch01 Mouse IS95 High 0.64 to 0.66 0.685 0.17/0.013 0.62 0.74 97500/97500 1.000 Ch02 Mouse IS95 Med 0.46 to 0.46 0.492 0.20/0.012 0.45 0.54 97500/97500 1.000 Ch03 Mouse IS95 Low 0.32 to 0.33 0.333 0.18/0.007 0.30 0.36 97500/97500 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 97496/97496 1.000 a Ch=chamber (e.g., Ch01=Chamber 1) I-32 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE I8 Summary of CDMA-Modulated Cell Phone RFR Exposure Data – H-Field Target Range Mean Stdev Min Max In Range/ Chamber [V/m] [V/m] [dB]/[V/m] [V/m] [V/m] Total Ratio January 1 to 31, 2013 Ch01 Mouse IS95 High 0.66 to 0.66 0.697 0.17/0.014 0.63 0.77 97378/97378 1.000 Ch02 Mouse IS95 Med 0.46 to 0.47 0.497 0.19/0.011 0.45 0.55 97378/97378 1.000 Ch03 Mouse IS95 Low 0.33 to 0.33 0.342 0.18/0.007 0.31 0.38 97378/97378 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 97364/97364 1.000 February 1 to 28, 2013 Ch01 Mouse IS95 High 0.66 to 0.67 0.702 0.16/0.013 0.65 0.77 88116/88116 1.000 Ch02 Mouse IS95 Med 0.47 to 0.47 0.508 0.21/0.012 0.46 0.61 88114/88116 1.000 Ch03 Mouse IS95 Low 0.33 to 0.33 0.347 0.18/0.007 0.32 0.38 88116/88116 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 88116/88116 1.000 March 1 to 31, 2013 Ch01 Mouse IS95 High 0.67 to 0.67 0.710 0.19/0.015 0.65 0.77 97784/97784 1.000 Ch02 Mouse IS95 Med 0.47 to 0.48 0.511 0.22/0.013 0.46 0.56 97784/97784 1.000 Ch03 Mouse IS95 Low 0.33 to 0.34 0.344 0.19/0.008 0.32 0.38 97784/97784 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 97784/97784 1.000 April 1 to 30, 2013 Ch01 Mouse IS95 High 0.67 to 0.68 0.713 0.20/0.016 0.65 0.82 96260/96260 1.000 Ch02 Mouse IS95 Med 0.48 to 0.48 0.511 0.19/0.011 0.47 0.56 96260/96260 1.000 Ch03 Mouse IS95 Low 0.34 to 0.34 0.348 0.18/0.007 0.32 0.38 96260/96260 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 96260/96260 1.000 May 1 to 31, 2013 Ch01 Mouse IS95 High 0.68 to 0.69 0.716 0.19/0.016 0.63 0.79 97020/97020 1.000 Ch02 Mouse IS95 Med 0.48 to 0.49 0.518 0.21/0.013 0.46 0.59 97020/97020 1.000 Ch03 Mouse IS95 Low 0.34 to 0.34 0.351 0.17/0.007 0.32 0.39 97020/97020 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 97020/97020 1.000 June 1 to 30, 2013 Ch01 Mouse IS95 High 0.69 to 0.69 0.722 0.20/0.017 0.64 0.84 94514/94514 1.000 Ch02 Mouse IS95 Med 0.49 to 0.49 0.521 0.21/0.013 0.46 0.57 94514/94514 1.000 Ch03 Mouse IS95 Low 0.34 to 0.35 0.345 0.53/0.022 0.28 0.43 94512/94514 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 94496/94496 1.000 July 1 to 31, 2013 Ch01 Mouse IS95 High 0.69 to 0.69 0.723 0.21/0.018 0.63 0.84 99146/99146 1.000 Ch02 Mouse IS95 Med 0.49 to 0.49 0.523 0.21/0.013 0.48 0.58 99146/99146 1.000 Ch03 Mouse IS95 Low 0.35 to 0.35 0.316 0.45/0.017 0.28 0.41 99146/99146 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 99146/99146 1.000 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 I-33 Peer Review Draft NOT FOR ATTRIBUTION TABLE I8 Summary of CDMA-Modulated Cell Phone RFR Exposure Data – H-Field Target Range Mean Stdev Min Max In Range/ Chamber [V/m] [V/m] [dB]/[V/m] [V/m] [V/m] Total Ratio August 1 to 31, 2013 Ch01 Mouse IS95 High 0.69 to 0.70 0.727 0.19/0.016 0.60 0.81 101712/101712 1.000 Ch02 Mouse IS95 Med 0.49 to 0.49 0.529 0.22/0.013 0.48 0.62 101710/101712 1.000 Ch03 Mouse IS95 Low 0.35 to 0.35 0.303 0.18/0.006 0.28 0.35 101712/101712 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 101700/101700 1.000 September 1 to 30, 2013 Ch01 Mouse IS95 High 0.70 to 0.73 0.726 0.19/0.016 0.63 0.85 93922/93922 1.000 Ch02 Mouse IS95 Med 0.49 to 0.50 0.531 0.22/0.013 0.47 0.59 93922/93922 1.000 Ch03 Mouse IS95 Low 0.35 to 0.35 0.336 0.62/0.025 0.22 0.45 93914/93922 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 93920/93920 1.000 October 1 to 31, 2013 Ch01 Mouse IS95 High 0.70 to 0.70 0.733 0.19/0.016 0.66 0.82 100816/100816 1.000 Ch02 Mouse IS95 Med 0.50 to 0.50 0.535 0.22/0.013 0.49 0.63 100816/100816 1.000 Ch03 Mouse IS95 Low 0.35 to 0.35 0.330 0.22/0.008 0.29 0.41 100816/100816 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 100816/100816 1.000 November 1 to 30, 2013 Ch01 Mouse IS95 High 0.70 to 0.70 0.724 0.20/0.017 0.48 0.81 93274/93278 1.000 Ch02 Mouse IS95 Med 0.50 to 0.50 0.532 0.23/0.014 0.36 0.59 93276/93278 1.000 Ch03 Mouse IS95 Low 0.35 to 0.35 0.327 0.27/0.010 0.19 0.43 93096/93278 0.998 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 93226/93226 1.000 December 1 to 31, 2013 Ch01 Mouse IS95 High 0.70 to 0.70 0.693 0.25/0.020 0.59 0.82 96846/96846 1.000 Ch02 Mouse IS95 Med 0.49 to 0.50 0.524 0.24/0.015 0.46 0.62 96844/96846 1.000 Ch03 Mouse IS95 Low 0.35 to 0.35 0.321 0.19/0.007 0.28 0.36 96846/96846 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 96846/96846 1.000 January 1 to 31, 2014 Ch01 Mouse IS95 High 0.70 to 0.70 0.703 0.22/0.018 0.57 0.81 97554/97554 1.000 Ch02 Mouse IS95 Med 0.49 to 0.50 0.532 0.22/0.014 0.27 0.62 97550/97554 1.000 Ch03 Mouse IS95 Low 0.35 to 0.35 0.329 0.39/0.015 0.14 0.41 97542/97552 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 97550/97550 1.000 February 1 to 28, 2014 Ch01 Mouse IS95 High 0.70 to 0.70 0.727 0.21/0.018 0.59 0.86 88184/88184 1.000 Ch02 Mouse IS95 Med 0.50 to 0.50 0.534 0.24/0.015 0.36 0.74 88170/88184 1.000 Ch03 Mouse IS95 Low 0.35 to 0.35 0.353 0.70/0.029 0.27 0.41 88180/88184 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 88184/88184 1.000 I-34 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE I8 Summary of CDMA-Modulated Cell Phone RFR Exposure Data – H-Field Target Range Mean Stdev Min Max In Range/ Chamber [V/m] [V/m] [dB]/[V/m] [V/m] [V/m] Total Ratio March 1 to 31, 2014 Ch01 Mouse IS95 High 0.70 to 0.70 0.694 0.65/0.054 0.10 0.90 96954/97180 0.998 Ch02 Mouse IS95 Med 0.50 to 0.50 0.520 0.21/0.013 0.34 0.71 97170/97180 1.000 Ch03 Mouse IS95 Low 0.35 to 0.35 0.365 0.43/0.019 0.19 0.58 97036/97180 0.999 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 97142/97142 1.000 April 1 to 30, 2014 Ch01 Mouse IS95 High 0.69 to 0.70 0.722 0.31/0.026 0.15 1.03 94494/94550 0.999 Ch02 Mouse IS95 Med 0.49 to 0.50 0.522 0.28/0.017 0.21 0.83 94406/94550 0.998 Ch03 Mouse IS95 Low 0.35 to 0.35 0.345 0.38/0.015 0.18 0.42 94540/94550 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 94548/94548 1.000 May 1 to 31, 2014 Ch01 Mouse IS95 High 0.69 to 0.69 0.721 0.21/0.017 0.64 0.82 97244/97244 1.000 Ch02 Mouse IS95 Med 0.49 to 0.49 0.521 0.20/0.012 0.46 0.60 97244/97244 1.000 Ch03 Mouse IS95 Low 0.35 to 0.35 0.354 0.37/0.016 0.26 0.42 97240/97244 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 97244/97244 1.000 June 1 to 30, 2014 Ch01 Mouse IS95 High 0.69 to 0.69 0.710 0.17/0.014 0.60 0.79 94288/94288 1.000 Ch02 Mouse IS95 Med 0.49 to 0.49 0.509 0.24/0.014 0.41 0.57 94288/94288 1.000 Ch03 Mouse IS95 Low 0.35 to 0.35 0.361 0.27/0.011 0.24 0.43 94276/94288 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 94288/94288 1.000 July 1 to 9, 2014 Ch01 Mouse IS95 High 0.69 to 0.69 0.701 0.14/0.011 0.65 0.76 25098/25098 1.000 Ch02 Mouse IS95 Med 0.49 to 0.49 0.491 0.14/0.008 0.44 0.53 25098/25098 1.000 Ch03 Mouse IS95 Low 0.35 to 0.35 0.355 0.68/0.029 0.19 0.49 24740/25098 0.986 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 25064/25064 1.000 June 18, 2012, to July 9, 2014 Ch01 Mouse IS95 High 0.52 to 0.73 0.694 0.29/0.023 0.10 1.03 2272276/2272568 1.000 Ch02 Mouse IS95 Med 0.36 to 0.50 0.504 0.23/0.013 0.21 0.83 2272380/2272568 1.000 Ch03 Mouse IS95 Low 0.26 to 0.35 0.331 0.53/0.021 0.14 0.58 2272194/2272566 1.000 Ch13 Mouse Sham 0.00 to 0.00 0.000 –/0.000 0.00 0.00 2272416/2272416 1.000 J-1 Peer Review Draft NOT FOR ATTRIBUTION APPENDIX J INGREDIENTS, NUTRIENT COMPOSITION, AND CONTAMINANT LEVELS IN NTP-2000 RAT AND MOUSE RATION TABLE J1 Ingredients of NTP-2000 Rat and Mouse Ration .............................................................................J-2 TABLE J2 Vitamins and Minerals in NTP-2000 Rat and Mouse Ration..........................................................J-2 TABLE J3 Nutrient Composition of NTP-2000 Rat and Mouse Ration............................................................J-3 TABLE J4 Contaminant Levels in NTP-2000 Rat and Mouse Ration ..............................................................J-4 J-2 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE J1 Ingredients of NTP-2000 Rat and Mouse Ration Ingredients Percent by Weight Ground hard winter wheat 22.26 Ground #2 yellow shelled corn 22.18 Wheat middlings 15.0 Oat hulls 8.5 Alfalfa meal (dehydrated, 17% protein) 7.5 Purified cellulose 5.5 Soybean meal (49% protein) 5.0 Fish meal (60% protein) 4.0 Corn oil (without preservatives) 3.0 Soy oil (without preservatives) 3.0 Dried brewer’s yeast 1.0 Calcium carbonate (USP) 0.9 Vitamin premixa 0.5 Mineral premixb 0.5 Calcium phosphate, dibasic (USP) 0.4 Sodium chloride 0.3 Choline chloride (70% choline) 0.26 Methionine 0.2 a Wheat middlings as carrier b Calcium carbonate as carrier TABLE J2 Vitamins and Minerals in NTP-2000 Rat and Mouse Rationa Amount Source Vitamins A 4,000 IU Stabilized vitamin A palmitate or acetate D 1,000 IU D-activated animal sterol K 1.0 mg Menadione sodium bisulfite complex α-Tocopheryl acetate 100 IU Niacin 23 mg Folic acid 1.1 mg d-Pantothenic acid 10 mg d-Calcium pantothenate Riboflavin 3.3 mg Thiamine 4 mg Thiamine mononitrate B12 52 µg Pyridoxine 6.3 mg Pyridoxine hydrochloride Biotin 0.2 mg d-Biotin Minerals Magnesium 514 mg Magnesium oxide Iron 35 mg Iron sulfate Zinc 12 mg Zinc oxide Manganese 10 mg Manganese oxide Copper 2.0 mg Copper sulfate Iodine 0.2 mg Calcium iodate Chromium 0.2 mg Chromium acetate a Per kg of finished product GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 J-3 Peer Review Draft NOT FOR ATTRIBUTION TABLE J3 Nutrient Composition of NTP-2000 Rat and Mouse Ration Nutrient Mean ± Standard Deviation Range Number of Samples Protein (% by weight) 14.4 ± 0.38 13.9 – 15.1 17 Crude fat (% by weight) 8.4 ± 0.37 7.7 – 9.2 17 Crude fiber (% by weight) 9.4 ± 0.41 8.6 – 9.9 17 Ash (% by weight) 4.9 ± 0.13 4.7 – 5.1 17 Amino Acids (% of total diet) Arginine 0.794 ± 0.070 0.67 – 0.97 26 Cystine 0.220 ± 0.022 0.15 – 0.25 26 Glycine 0.700 ± 0.038 0.62 – 0.80 26 Histidine 0.344 ± 0.074 0.27 – 0.68 26 Isoleucine 0.546 ± 0.041 0.43 – 0.66 26 Leucine 1.092 ± 0.063 0.96 – 1.24 26 Lysine 0.700 ± 0.110 0.31 – 0.86 26 Methionine 0.408 ± 0.043 0.26 – 0.49 26 Phenylalanine 0.621 ± 0.048 0.47 – 0.72 26 Threonine 0.508 ± 0.040 0.43 – 0.61 26 Tryptophan 0.153 ± 0.027 0.11 – 0.20 26 Tyrosine 0.413 ± 0.063 0.28 – 0.54 26 Valine 0.663 ± 0.040 0.55 – 0.73 26 Essential Fatty Acids (% of total diet) Linoleic 3.95 ± 0.242 3.49 – 4.55 26 Linolenic 0.31 ± 0.030 0.21 – 0.35 26 Vitamins Vitamin A (IU/kg) 3,899 ± 77 2,820 – 5,450 17 Vitamin D (IU/kg) 1,000a α-Tocopherol (ppm) 79.7 ± 20.42 27.0 – 124.0 26 Thiamine (ppm)b 11.8 ± 17.85 6.6 – 81.0 17 Riboflavin (ppm) 8.1 ± 2.91 4.20 – 17.50 26 Niacin (ppm) 78.9 ± 8.52 66.4 – 98.2 26 Pantothenic acid (ppm) 26.7 ± 11.63 17.4 – 81.0 26 Pyridoxine (ppm)b 9.7 ± 2.09 6.44 – 14.3 26 Folic acid (ppm) 1.59 ± 0.45 1.15 – 3.27 26 Biotin (ppm) 0.32 ± 0.10 0.20 – 0.704 26 Vitamin B12 (ppb) 51.8 ± 36.6 18.3 – 174.0 26 Choline (ppm)b 2,665 ± 631 1,160 – 3,790 26 Minerals Calcium (%) 0.903 ± 0.070 0.697 – 1.01 17 Phosphorus (%) 0.553 ± 0.026 0.510 – 0.596 17 Potassium (%) 0.669 ± 0.030 0.626 – 0.733 26 Chloride (%) 0.386 ± 0.037 0.300 – 0.474 26 Sodium (%) 0.193 ± 0.024 0.160 – 0.283 26 Magnesium (%) 0.216 ± 0.057 0.185 – 0.490 26 Sulfur (%) 0.170 ± 0.029 0.116 – 0.209 14 Iron (ppm) 190.5 ± 38.0 135 – 311 26 Manganese (ppm) 50.7 ± 9.72 21.0 – 73.1 26 Zinc (ppm) 58.2 ± 26.89 43.3 – 184.0 26 Copper (ppm) 7.44 ± 2.60 3.21 – 16.3 26 Iodine (ppm) 0.514 ± 0.195 0.158 – 0.972 26 Chromium (ppm) 0.674 ± 0.265 0.330 – 1.380 25 Cobalt (ppm) 0.235 ± 0.157 0.094 – 0.864 24 a From formulation b As hydrochloride (thiamine and pyridoxine) or chloride (choline) J-4 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft TABLE J4 Contaminant Levels in NTP-2000 Rat and Mouse Rationa Mean ± Standard Deviationb Range Number of Samples Contaminants Arsenic (ppm) 0.20 ± 0.039 0.14 – 0.28 17 Cadmium (ppm) 0.05 ± 0.004 0.04 – 0.06 17 Lead (ppm) 0.21 ± 0.027 0.07 – 1.19 17 Mercury (ppm) <0.02 17 Selenium (ppm) 0.17 ± 0.024 0.10 – 0.20 17 Aflatoxins (ppb) <5.00 17 Nitrate nitrogen (ppm)c 18.76 ± 9.49 10.0 – 45.9 17 Nitrite nitrogen (ppm)c 0.61 17 BHA (ppm)d <1.0 17 BHT (ppm)d <1.0 17 Aerobic plate count (CFU/g) <10.0 17 Coliform (MPN/g) 3.0 17 Escherichia coli (MPN/g) <10 17 Salmonella (MPN/g) Negative 17 Total nitrosoamines (ppb)e 9.2 ± 5.55 0.0 – 19.9 17 N-Nitrosodimethylamine (ppb)e 1.3 ± 1.04 0.0 – 3.0 17 N-Nitrosopyrrolidine (ppb)e 8.0 ± 5.02 0.0 – 18.6 17 Pesticides (ppm) α-BHC <0.01 17 β-BHC <0.02 17 γ-BHC <0.01 17 δ-BHC <0.01 17 Heptachlor <0.01 17 Aldrin <0.01 17 Heptachlor epoxide <0.01 17 DDE <0.01 17 DDD <0.01 17 DDT <0.01 17 HCB <0.01 17 Mirex <0.01 17 Methoxychlor <0.05 17 Dieldrin <0.01 17 Endrin <0.01 17 Telodrin <0.01 17 Chlordane <0.05 17 Toxaphene <0.10 17 Estimated PCBs <0.20 17 Ronnel <0.01 17 Ethion <0.02 17 Trithion <0.05 17 Diazinon <0.10 17 Methyl chlorpyrifos 0.16 ± 0.179 0.02 – 0.686 17 Methyl parathion <0.02 17 Ethyl parathion <0.02 17 Malathion 0.117 ± 0.140 0.02 – 0.585 17 Endosulfan I <0.01 17 Endosulfan II <0.01 17 Endosulfan sulfate <0.03 17 a All samples were irradiated. CFU=colony-forming units; MPN=most probable number; BHC=hexachlorocyclohexane or benzene hexachloride b For values less than the limit of detection, the detection limit is given as the mean. c Sources of contamination: alfalfa, grains, and fish meal d Sources of contamination: soy oil and fish meal e All values were corrected for percent recovery. K-1 Peer Review Draft NOT FOR ATTRIBUTION APPENDIX K SENTINEL ANIMAL PROGRAM METHODS................................................................................................................................................................. K-2 RESULTS................................................................................................................................................................... K-3 K-2 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft SENTINEL ANIMAL PROGRAM METHODS Rodents used in the National Toxicology Program are produced in optimally clean facilities to eliminate potential pathogens that may affect study results. The Sentinel Animal Program is part of the periodic monitoring of animal health that occurs during the toxicologic evaluation of test agents. Under this program, the disease state of the rodents is monitored via sera or feces from extra (sentinel) or dosed animals in the study rooms. The sentinel animals and the study animals are subject to identical environmental conditions. Furthermore, the sentinel animals come from the same production source and weanling groups as the animals used for the studies of test agents. Blood samples were collected and allowed to clot, and the serum was separated. All samples were processed appropriately with serology testing performed by IDEXX BioResearch [formerly Research Animal Diagnostic Laboratory (RADIL), University of Missouri, Columbia, MO] for determination of the presence of pathogens. The laboratory methods and agents for which testing was performed are tabulated below; the times at which samples were collected during the studies are also listed. Blood was collected from five mice per sex per time point except for the following: 28-day studies, study termination collection: Two males and eight females 2-year studies, study termination collection: 10 males and 10 females Method and Test Time of Collection 28-Day Studies Multiplex Fluorescent Immunoassay Ectromelia virus Study termination EDIM (epizootic diarrhea of infant mice) Study termination LCMV (lymphocytic choriomeningitis virus) Study termination Mycoplasma pulmonis Study termination MHV (mouse hepatitis virus) Study termination MNV (mouse norovirus) Study termination MPV (mouse parvovirus) Study termination MVM (minute virus of mice) Study termination PVM (pneumonia virus of mice) Study termination REO3 (reovirus) Study termination Sendai Study termination TMEV (Theiler’s murine encephalomyelitis virus) Study termination GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 K-3 Peer Review Draft NOT FOR ATTRIBUTION Method and Test Time of Collection 2-Year Studies Multiplex Fluorescent Immunoassay Ectromelia virus End of quarantine, 4 weeks, 6, 12, and 18 months, study termination EDIM End of quarantine, 4 weeks, 6, 12, and 18 months, study termination LCMV End of quarantine, 4 weeks, 6, 12, and 18 months, study termination M. pulmonis End of quarantine, 4 weeks, 6, 12, and 18 months, study termination MHV End of quarantine, 4 weeks, 6, 12, and 18 months, study termination MNV End of quarantine, 4 weeks, 6, 12, and 18 months, study termination MPV End of quarantine, 4 weeks, 6, 12, and 18 months, study termination MVM End of quarantine, 4 weeks, 6, 12, and 18 months, study termination PVM End of quarantine, 4 weeks, 6, 12, and 18 months, study termination REO3 End of quarantine, 4 weeks, 6, 12, and 18 months, study termination Sendai End of quarantine, 4 weeks, 6, 12, and 18 months, study termination TMEV End of quarantine, 4 weeks, 6, 12, and 18 months, study termination Immunofluorescence Assay MNV Study termination Polymerase Chain Reaction Helicobacter species 18 months RESULTS All test results were negative. K-4 GSM- and CDMA-Modulated Cell Phone RFR, NTP TR 596 NOT FOR ATTRIBUTION Peer Review Draft