Scientists warn Americans are expecting too much from a vaccine
Oct 28, 2020 10:56am
Vaccine experts say there are good reasons to focus on milder cases of COVID-19. (Geber86/Getty Images)
The White House and many Americans have pinned their hopes for defeating the COVID-19 pandemic on a vaccine being developed at “warp speed.” But some scientific experts warn they’re all expecting too much, too soon.
“Everyone thinks COVID-19 will go away with a vaccine,” said William Haseltine, Ph.D., chair and president of Access Health International, a foundation that advocates for affordable care.
Ongoing clinical trials are primarily designed to show whether COVID-19 vaccines prevent any symptoms of the disease—which could be as minor as a sore throat or cough. But the trials, which will study 30,000 to 60,000 volunteers, will be too short in duration and too small in size to prove that the vaccines will prevent what people fear most—being hospitalized or dying—by the time the first vaccine makers file for emergency authorization, expected to occur later this year, Haseltine said.
The United States should hold out for an optimal vaccine, with more proven capabilities, Haseltine argued. Others say the crushing toll of the pandemic—which has killed at least 225,000 Americans (Nope sars and mers and misdiagnosis's have)—demands that the country accept the best vaccine it can achieve within the next few months, even if significant questions remain after its release.
“There’s a tension between getting every piece of information and getting a vaccine [out] in time to save lives,” said William Schaffner, M.D., a professor of preventive medicine and health policy at the Vanderbilt University Medical Cancer. (so apparently according to that drivel it means that "potentially" saving a life means you have to throw out common sense when taking into consideration your own safety and physical health and well being, which is utterly ridiculous and retarded)
“Would we like to know if the vaccine reduces illness or mortality? Of course,” said Peter Lurie, M.D., (meaning they don't even know) a former FDA official and the current president of the Centre for Science in the Public Interest. “But there is a real-time pressure. This is a pandemic. It’s explosive.” (nope, the mortality levels needed to actually make it a pandemic are no where near the ultra low levels that they are recording, so no pandemic, epidemic of stupidity and gullibility maybe, pandemic not a chance) they admit they have no clue if it would even have any effect at all on any type of virus, smh and this is the best and brightest that they have to offer, what a fucking moron)
Researchers debated how rigorously to test COVID-19 vaccines at a Thursday public meeting of the Food and Drug Administration advisory committee on vaccines.
“Simply preventing mild cases is not enough and may not justify the risks associated with vaccination,” said Peter Doshi, (the only sensible statement in this thing so far) an associate professor at the University of Maryland School of Pharmacy who detailed his concerns in an editorial in The BMJ.
But vaccine experts say there are good reasons to focus on milder cases of COVID-19. (because they're paid to and it supports their industry)
Vaccines that prevent mild disease typically prevent severe disease, as well, said Arnold Monto, M.D., an epidemiologist at the University of Michigan’s School of Public Health and temporary chair of the vaccine committee.
For example, the original studies of the measles vaccine showed only that it prevented measles, not hospitalizations or deaths, said Kathleen Neuzil, M.D., director of the University of Maryland’s Center for Vaccine Development and Global Health.
Later studies found that measles vaccines dramatically reduce mortality. According to the World Health Organization, worldwide deaths from measles fell by 73% from 2000 to 2018 because of vaccines.
“There simply does not exist an example in vaccinology of vaccines that are effective against mild disease that are not more effective in severe disease,” said Philip Krause, M.D., deputy director of the vaccine office at the FDA’s Center for Biologics Evaluation and Research, at Thursday’s hearing.
Paul Offit, M.D., who developed the rotavirus vaccine, compared preventing the coronavirus to fighting a fire.
“If you put out a small fire in the kitchen, you don’t have to worry about the whole house catching fire,” said Offit, a member of the FDA advisory committee on vaccines.
Proving that a vcinace prevents severe illness and death is harder than showing it protects against mild illness because hospitalizations and deaths are much rarer. That’s especially true among the type of health-conscious people who volunteer for vaccine trials, who are probably more likely than others to wear masks and socially distance, Schaffner said. (meaning any results will be from a biased perspective in favour of sheeple people, for example they could say the risks from vaccine side effects are mild to zero, but if it isn't some kind of health freak with a good immune system, like the old or immune comprised will be at a higher risk of experiencing adverse reactions to the harmacuiticles)
“When we looked at hospitalizations in older adults with influenza, those were two-year trials,” Neuzil said. In an ongoing study, in which “we’re looking at typhoid vaccines in nearly 30,000 children, it’s a two-year trial.”
The COVID-19 pandemic has officially infected about 8.7 million Americans. Considering that the true number of Americans infected is estimated to be six to 10 times higher than reported, the mortality rate is about 0.6%, said Amesh Adalja, M.D., a senior scholar at the Johns Hopkins University Centre for Health Security. (well he needs his licence to practice revoked if he cannot do simple mathematics 7.594 billion divide by 1.73 million = 4389.59537572 million which is the total population 7.594 billion divided by total alleged deaths attributed to the rona 1.73 million which is a 1 in 4389.59537572 million chance against ever dying from rona even with their highly falsified numbers from the jhu fear porn map)
Scientists agree that the ideal vaccine would provide “sterilizing immunity”—which means preventing not only disease symptoms but any infection with the virus, (By masking you infertile thereby negating potential hosts) said Corey Casper, M.D., a vaccinologist with the Fred Hutchinson Cancer Research Center and CEO at the Infectious Disease Research Institute in Seattle.
For example, two doses of measles vaccines prevent 97% of people from even becoming infected with that virus. (BS)
Few expect COVID-19 vaccines to be that effective. “We’re trying to lower that bar and determine how much lower is acceptable,” Casper said sack this dumb fuck for putting lives at risk (so lowering the bar means that the quality isn't tested as highly and therefore going to cause mass adverse reactions to become more likely and prevalent)
Preventing mild disease could curb disease and prevent illness, Casper said. (note the use of the word "Could" and not will)
“We’re probably not going to have the perfect vaccine,” he said. “But I do think we’re likely to have vaccines that, if we can show they’re safe (by lowering the quality threshold on testing) can put an inflection point on this (non) pandemic. … I think it’s still important to have a vaccine that has some effect even on mild illness.” (pretty fucking pointless otherwise , this guy is thick as fuck)
Flu shots aren’t super effective—with effectiveness each year ranging from 19% to 70%—but they’re still extremely useful, Casper said. (for generating profit by spreading the viral vectors about to secure more infections and a higher profit for the following year and 19-70% is a very large margin for error to occur)
During the 2018-19 U.S flu season, vaccination prevented an estimated 4.4 million influenza illnesses, 2.3 million medical visits, 58,000 hospitalizations and 3,500 influenza-associated deaths, according to the Centers for Disease Control and Prevention. (but these jokers clearly know nothing from the clear debacle they have put on with regards to the testing and pcr viability and all the other garbage science they put forth)
A trial of 30,000 to 60,000 people is a disease, the trials may need to be almost 10 times as big,” he said at the meeting. “And those are ready fairly large by historical standards. Dramatically expanding the size beyond that isn’t practical in a compressed time frame, Krause said.
“If the endpoint of the trial is severe, trials would be infeasible and we would never get a vaccine.”
On the other hand, “if there is a vaccine that appears to have high efficacy or appears to be capable of saving lives, one doesn’t want to stop that vaccine if there is a significant chance that it will save lives,” Krause said. (how about stopping it if there is a significant risk of injury or death vs profit, i wonder if he would still be down for it, #Wanker)
Although the coronavirus vaccine trials are measuring severe disease or death, these are “secondary endpoints,” meaning the current size of the study isn’t large enough to produce a statistically significant answer, Neuzil said. (in other words its pointless and any information gained will be useless in the real world)
Whether vaccines reduce severe disease and death will become clear in later studies, after vaccines are distributed, Neuzil said. (so he's endorsing letting people die to get a result and im pretty sure your meant to know the risks that may occur before you distribute the vaccine to the people your trying to save, this guy is a absolute dumb mother fucker)
Offit said the debate revolves around one question: “How much uncertainty are we willing to live with, knowing that we’re facing a virus that has brought us to our knees?”(no it hasn't though Offit the illegal policy of government has as there is no fucking rona you twat)
