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DARPAtv
Project GreenVax is a research and development demonstration project funded by the Defense Advanced Research Projects Agency and conducted by the Texas Plant-Expressed Vaccine Consortium located in Bryan, TX. The goal of this project is to develop a capability to produce 1kg (or approximately 10 million doses) of a recombinant vaccine candidate protein in one month. To succeed in this effort, the project GreenVax team created numerous innovative solutions to maximize efficiencies to both their upstream and downstream processes including new lighting systems capable of doubling plant biomass generated and use of mobile Modular Bioprocessing Facilities, which provide the flexibility to manufacture multiple products at the same time. If this effort is successful, it could provide a strategic resource for the United States and its ability to rapidly produce medical countermeasures against any biothreat. For more information, please visit: http://www.darpa.mil/Our_Work/DSO/Pro...
made from tobacco so you become addicted to it
Plant expressed vaccine or project GreenVax[1] In 2005 DARPA’s Accelerated Manufacture of Pharmaceuticals (AMP) program was created In response to emerging and novel biologic threats.[2] In 2009 DARPA offered a government contract for a Non-GMO plant-based systems expressing recombinant proteins, due to The 2009 H1N1 swine flu pandemic that highlighted the national need for rapid and agile vaccine manufacturing capabilities.[3] The Texas A&M University and a Texas company have been awarded a $40 million U.S. Department of Defense grant to develop a plant expressed vaccine made from tobacco.[4] While egg-based vaccines typically take more than six months to develop after a virus is isolated, the new process will take only four to six weeks.[4] The vice chancellor for research at A&M System declared that if the project works it will be one of the largest and most capable vaccine facilities in the world.[4] However the major problem is the public acceptance of this technology, many of the companies are looking for the FDA approval [5]
The plant-based vaccine production method works by isolating a specific antigen protein, one that triggers a human immune response from the targeted virus. A gene from the protein is transferred to bacteria, which are then used to “infect” plant cells. The plants then start producing the exact protein that will be used for vaccinations.[6] Other uses of plant-expressed vaccines including the successful creation of edible bananas that protect against the Norwalk virus.[7]
References[edit]
^ "Archived copy" (PDF). Archived from the original (PDF) on 2010-05-24. Retrieved 2010-08-06.
^ "Archived copy". Archived from the original on 2016-03-03. Retrieved 2010-08-06.
^ "Scalable Manufacturing of Plant-Expressed Vaccines". DARPA. Archived from the original on 5 March 2016. Retrieved 6 August 2010.
^ Jump up to:a b c "A&M gets big grant to make tobacco-based vaccine". Houston Chronicle. Retrieved 6 August 2010.
^ McIntosh, Dwayne D. Kirk and Kim (2006-01-24). "Social Acceptance of Plant-Made Vaccines: Indications from a Public Survey". www.agbioforum.org. Retrieved 2018-04-03.
^ Drummond, Katie (24 February 2010). "Darpa-funded Researchers: Tobacco vs. Viral Terror". Wired.
^ Drummond, Katie (24 February 2010). "Darpa-funded Researchers: Tobacco vs. Viral Terror". Wired.
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Aflatoxin
Arsenic contamination of groundwater
Benzene in soft drinks
Bisphenol A
Dieldrin
Diethylstilbestrol
Dioxin
Mycotoxins
Nonylphenol
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Devon colic
Swill milk scandal
Esing Bakery incident
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1900 English beer poisoning
Morinaga Milk arsenic poisoning incident
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Toxic oil syndrome
1985 diethylene glycol wine scandal
UK mad cow disease outbreak
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1996 Odwalla E. coli outbreak
2006 North American E. coli outbreaks
ICA meat repackaging controversy
2008 Canada listeriosis outbreak
2008 Chinese milk scandal
2008 Irish pork crisis
2008 United States salmonellosis outbreak
2011 Germany E. coli outbreak
2011 United States listeriosis outbreak
2013 Bihar school meal poisoning
2013 horse meat scandal
2015 Mozambique beer poisoning
2017 Brazil weak meat scandal
2017–18 South African listeriosis outbreak
2018 Australian rockmelon listeriosis outbreak
2018 Australian strawberry contamination
Food safety incidents in China
Food safety incidents in Taiwan
Food safety in Australia
Foodborne illness
outbreaks
death toll
United States
Regulation, standards, watchdogs
Acceptable daily intake
E number
Food labeling regulations
Food libel laws
International Food Safety Network
ISO 22000
Nutrition facts label
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The Non-GMO Project
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Institutions
Institute for Food Safety and Health
European Food Safety Authority
International Food Safety Network
Spanish Agency for Food Safety and Nutrition
Food Information and Control Agency (Spain)
Centre for Food Safety (Hong Kong)
Ministry of Food and Drug Safety (South Korea)
Categories:
Vaccines
Live vaccines
Food industry
Genetically modified organisms in agriculture
Genetic engineering
Plant expressed vaccine or project GreenVax[1] In 2005 DARPA’s Accelerated Manufacture of Pharmaceuticals (AMP) program was created In response to emerging and novel biologic threats.[2] In 2009 DARPA offered a government contract for a Non-GMO plant-based systems expressing recombinant proteins, due to The 2009 H1N1 swine flu pandemic that highlighted the national need for rapid and agile vaccine manufacturing capabilities.[3] The Texas A&M University and a Texas company have been awarded a $40 million U.S. Department of Defense grant to develop a plant expressed vaccine made from tobacco.[4] While egg-based vaccines typically take more than six months to develop after a virus is isolated, the new process will take only four to six weeks.[4] The vice chancellor for research at A&M System declared that if the project works it will be one of the largest and most capable vaccine facilities in the world.[4] However the major problem is the public acceptance of this technology, many of the companies are looking for the FDA approval [5]
The plant-based vaccine production method works by isolating a specific antigen protein, one that triggers a human immune response from the targeted virus. A gene from the protein is transferred to bacteria, which are then used to “infect” plant cells. The plants then start producing the exact protein that will be used for vaccinations.[6] Other uses of plant-expressed vaccines including the successful creation of edible bananas that protect against the Norwalk virus.[7]
References[edit]
^ "Archived copy" (PDF). Archived from the original (PDF) on 2010-05-24. Retrieved 2010-08-06.
^ "Archived copy". Archived from the original on 2016-03-03. Retrieved 2010-08-06.
^ "Scalable Manufacturing of Plant-Expressed Vaccines". DARPA. Archived from the original on 5 March 2016. Retrieved 6 August 2010.
^ Jump up to:a b c "A&M gets big grant to make tobacco-based vaccine". Houston Chronicle. Retrieved 6 August 2010.
^ McIntosh, Dwayne D. Kirk and Kim (2006-01-24). "Social Acceptance of Plant-Made Vaccines: Indications from a Public Survey". www.agbioforum.org. Retrieved 2018-04-03.
^ Drummond, Katie (24 February 2010). "Darpa-funded Researchers: Tobacco vs. Viral Terror". Wired.
^ Drummond, Katie (24 February 2010). "Darpa-funded Researchers: Tobacco vs. Viral Terror". Wired.
hide
v
t
e
Genetic engineering
Genetically
modified
organisms
Crops
Maize
MON 810
MON 863
StarLink
List of varieties of genetically modified maize
Potato
Amflora
Rice
Golden rice
Soybean
Roundup ready soybean
Vistive Gold
Tomato
Flavr Savr
Cotton
Bt cotton
Other
Apple
Arabidopsis
Brinjal
Canola
Papaya
Rose
SmartStax
Sugar beet
Tobacco
Trees
Wheat
Mustard
Animals
Mammals
Mouse
Knockout mouse
Oncomouse
Enviropig
Herman the Bull
Knockout rat
Other animals
Insects
Fish
Glofish
Salmon
Birds
Frogs
Bacteria
and viruses
Ice-minus bacteria
Hepatitis B vaccine
Oncolytic virus
Processes
Inserting DNA
Agrobacteria
Biolistics
Electroporation
Genetic transduction
Lipofection
Microinjection
Somatic cell nuclear transfer
Transfection
Types
Recombinant DNA
Transgenesis
Cisgenesis
Uses
In agriculture
Genetically modified food
Controversies
Pharming
Companies
BASF
Bayer
Dow AgroSciences
DuPont Pioneer
Monsanto
Syngenta
In humans and
diagnostics
Gene therapy
Genetic enhancement
Genetic testing
In research
Gene knockout
Gene knockdown
Gene targeting
Related
articles
Transgene
Detection of genetically modified organisms
Genetic pollution
Genetics in fiction
Human enhancement
Reverse transfection
Transhumanism
Genetic use restriction technology
Regulation
Cartagena Protocol on Biosafety
Geography
Europe
Africa
Asia
North America (US)
South America
Oceania
Similar fields
Synthetic biology
Cloning
Stem cell research
Biology
Genetics
Biotechnology
Bioethics
hide
v
t
e
Consumer food safety
Adulterants, food contaminants
3-MCPD
Aldicarb
Antibiotic use in livestock
Cyanide
Formaldehyde
HGH controversies
Lead poisoning
Melamine
Mercury in fish
Sudan I
Flavorings
Monosodium glutamate (MSG)
Salt
Sugar
High-fructose corn syrup
Intestinal parasites and parasitic disease
Amoebiasis
Anisakiasis
Cryptosporidiosis
Cyclosporiasis
Diphyllobothriasis
Enterobiasis
Fasciolopsiasis
Fasciolosis
Giardiasis
Gnathostomiasis
Paragonimiasis
Toxoplasmosis
Trichinosis
Trichuriasis
Microorganisms
Botulism
Campylobacter jejuni
Clostridium perfringens
Cronobacter
Enterovirus
Escherichia coli O104:H4
Escherichia coli O157:H7
Hepatitis A
Hepatitis E
Listeria
Norovirus
Rotavirus
Salmonella
Vibrio cholerae
Pesticides
Chlorpyrifos
DDT
Lindane
Malathion
Methamidophos
Preservatives
Benzoic acid
Ethylenediaminetetraacetic acid (EDTA)
Sodium benzoate
Sugar substitutes
Acesulfame potassium
Aspartame
Saccharin
Sodium cyclamate
Sorbitol
Sucralose
Toxins, poisons, environment pollution
Aflatoxin
Arsenic contamination of groundwater
Benzene in soft drinks
Bisphenol A
Dieldrin
Diethylstilbestrol
Dioxin
Mycotoxins
Nonylphenol
Shellfish poisoning
Food contamination incidents
Devon colic
Swill milk scandal
Esing Bakery incident
1858 Bradford sweets poisoning
1900 English beer poisoning
Morinaga Milk arsenic poisoning incident
Minamata disease
1971 Iraq poison grain disaster
Toxic oil syndrome
1985 diethylene glycol wine scandal
UK mad cow disease outbreak
1993 Jack in the Box E. coli outbreak
1996 Odwalla E. coli outbreak
2006 North American E. coli outbreaks
ICA meat repackaging controversy
2008 Canada listeriosis outbreak
2008 Chinese milk scandal
2008 Irish pork crisis
2008 United States salmonellosis outbreak
2011 Germany E. coli outbreak
2011 United States listeriosis outbreak
2013 Bihar school meal poisoning
2013 horse meat scandal
2015 Mozambique beer poisoning
2017 Brazil weak meat scandal
2017–18 South African listeriosis outbreak
2018 Australian rockmelon listeriosis outbreak
2018 Australian strawberry contamination
Food safety incidents in China
Food safety incidents in Taiwan
Food safety in Australia
Foodborne illness
outbreaks
death toll
United States
Regulation, standards, watchdogs
Acceptable daily intake
E number
Food labeling regulations
Food libel laws
International Food Safety Network
ISO 22000
Nutrition facts label
Organic certification
The Non-GMO Project
Quality Assurance International
Institutions
Institute for Food Safety and Health
European Food Safety Authority
International Food Safety Network
Spanish Agency for Food Safety and Nutrition
Food Information and Control Agency (Spain)
Centre for Food Safety (Hong Kong)
Ministry of Food and Drug Safety (South Korea)
Categories:
Vaccines
Live vaccines
Food industry
Genetically modified organisms in agriculture
Genetic engineering
